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RNA World 2024

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科学顾问委员会

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往届回顾

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主要议题


                                                                        1. mRNA Vaccine & Therapy 

                                                                        2. siRNA & Other RNA Therapies

                                                                        3. Delivery Technologies

                                                                        4. Manufacturing and Scalability

                                                                        5. RNA Biology and New Technologies

                                                                        6. Market Access and Partnership

                                                                        7. Clinical Trials in RNA Therapies


酒店预订
活动嘉宾
  • Professor, Baylor College of Medicine, USAChonghui Cheng
    Chonghui Cheng
    Professor, Baylor College of Medicine, USA

    Dr. Chonghui Cheng is currently a Professor at Baylor College of Medicine in Houston, Texas, USA. She obtained a PhD from Sloan Kettering Institute/Cornell University working with Dr. Stewart Shuman and conducted postdoctoral training at MIT under Nobel Laureate Dr. Phillip Sharp. In 2007, Dr. Cheng joined the faculty at Northwestern University. In 2016, she was recruited to Baylor College of Medicine as a CPRIT Rising-Star Scholar. Dr Cheng has made major contributions to the understanding of alternative splicing in cancer. Her laboratory investigates the fundamental questions of how RNA regulation controls cellular processes in normal biology and in the context of cancer. Working at the interface of RNA splicing and breast cancer biology, Dr. Cheng’s research pioneered the findings that splice isoform switching causally controls epithelial-mesenchymal transition (EMT) and breast cancer metastasis. The research team in Dr. Cheng’s laboratory combines multidisciplinary approaches of molecular biology, genetics, and bioinformatics and aims to discover rules and networks of RNA binding proteins and alternative splicing that regulate breast cancer metastasis and to advance the development of novel therapeutics for the treatment of this deadly disease.


  • Professor, Oregan State University, USALiang Huang
    Liang Huang
    Professor, Oregan State University, USA

    Liang Huang (PhD, Penn, 2008) is a Professor of Computer Science at Oregon State University, and co-founder of Coderna.ai. Until recently, he was also a Distinguished Scientist at Baidu Research USA. He also worked at Google Research, USC, and City Univ. of New York. He was a leading natural natural language processing (NLP) researcher, but in recent years, he has shifted his attention to applying these natural language algorithms to computational biology, esp. RNA folding and RNA design, with the hope of fighting COVID. This line of linguistics-inspired biology work eventually led to PNAS (2021) and Nature (2023) papers, and is widely covered in the media.

  • Professor, Fudan UniversityLiang  Qu
    Liang Qu
    Professor, Fudan University

    璩良, 复旦大学基础医学院研究员、博士生导师、课题组长。2022年入职复旦大学基础医学院,组建RNA疫苗技术与免疫治疗实验室,致力于新型RNA疫苗及治疗技术开发与免疫治疗研究。璩良博士开发了不依赖CRISPR/Cas系统的RNA编辑技术—LEAPER(Nature Biotechnology,2019)及其迭代升级版LEAPER2.0(Nature Biotechnology,2022),入选《国家十三五科技创新成就展》;国际上首次报道circRNA疫苗技术平台、拓展了RNA治疗技术新领域(Cell,2022);获吴瑞纪念基金会吴瑞奖(2020)、入选国家博新计划(2020)和上海市晨光计划(2023);主持科技部国家重点研发计划课题(2023,核糖核酸底层技术研发)和上海市科委合成生物学重点专项(2023,新型RNA疫苗/治疗技术的开发)等项目支持。

  • Postdoctoral Fellow, RNA Therapeutics Institute, USAQi Tang
    Qi Tang
    Postdoctoral Fellow, RNA Therapeutics Institute, USA

    Qi received his PhD in Pharmaceutical Sciences with a specialization in chemical biology of nucleic acids from the University of Rhode Island in 2019. He is currently a postdoctoral fellow in the Anastasia Khvorova Lab at the RNA Therapeutics Institute, where he is working on engineering small-interfering RNAs to address unmet needs in the treatment of inflammatory disorders. He has recently led the design of an immunomodulatory JAK1-selective siRNA, and the investigational drug is licensed to Aldena Therapeutics and is currently under clinical development for treating inflammatory skin diseases. Qi is a recipient of the 2023 NIH K99/R00 Pathway to Independence Award and is establishing his lab at the University of Massachusetts Chan Medical School with a primary focus on chemical biology and preclinical development of therapeutic RNAs.


  • Assistant Professor, Sapienza University of Rome, ItalyEleni Anastasiadou,
    Eleni Anastasiadou,
    Assistant Professor, Sapienza University of Rome, Italy

    Eleni Anastasiadou received her Ph.D. from La Sapienza, University of Rome, Italy, specializing in microbiology and virology. She focused on the interactions of cellular miRNAs with Epstein Barr Virus latent proteins in lymphoma. Her pioneering work led to the identification of how viral proteins subvert cellular miRNAs and contribute to cancer. During her work at Beth Israel Deaconess Medical Center/Harvard Medical School, Boston has developed an RNA-aided cancer immunotherapy method and a bench-to-bedside delivery of miRNAs in lymphomas. Currently, she is an Assistant Professor at La Sapienza University, focused on the role of miRNAs in regulating immune responses in cancer.


  • Managing Partner& CEO,PRAMOMOLECULAR, GermanyMerle Fuchs
    Merle Fuchs
    Managing Partner& CEO,PRAMOMOLECULAR, Germany

    Merle Fuchs is Co-Founder and CEO of PRAMOMOLECULAR GmbH, a biotech startup based in Berlin. PRAMOMOLECULAR develops therapeutics based on short interfering RNAs (siRNAs) to downregulate oncoproteins in lung, pancreas, and skin. She benefits from her scientific background as a micro- and molecular biologist as well as from her previous experience in setting up “TechnologieContor”, a consulting company for high-tech start-ups and innovative grown-ups with a focus on business development and financing. Merle Fuchs is Co-Founder of seven other high-tech startups.

  • Executive VP, Suzhou Ribo Life ScienceCharles Tong
    Charles Tong
    Executive VP, Suzhou Ribo Life Science

    Charles C. Tong, Ph.D., Executive Vice President and Head of R&D Center, has been engaged in the oligonucleotide therapeutics research and development at Suzhou Ribo Life Science since 2016. He has more than 27 years of extensive working experience in the pharmaceutical industry, including various scientific and leadership roles in R&D organizations in pharma and biotechnology companies to advance products from preclinical research, clinical development to market authorization. Prior to his current position, he served as General Manager of R&D Center at Hisun-Pfizer Pharmaceuticals, Senior Director of Pharmaceutical Sciences at Pfizer Inc., as well as Chair of International Society for Pharmaceutical Engineering (ISPE) China.


  • Assistant Professor, University of British Columbia, CanadaAnna Blakney,
    Anna Blakney,
    Assistant Professor, University of British Columbia, Canada

    Dr. Blakney is an Assistant Professor and Tier 2 Canada Research Chair in the Michael Smith Laboratories and School of Biomedical Engineering at UBC. She received her Bachelor of Science in Chemical & Biological Engineering from the University of Colorado at Boulder, and her PhD in Bioengineering from the University of Washington. She completed a postdoctoral fellowship at Imperial College London on the development of molecular and biomaterial engineering strategies for delivery of self-amplifying RNA. Her lab uses bioengineering, molecular biology and immunology approaches to develop the next generation of RNA vaccines and therapies. Her research has been published in a variety of top tier journals including ACS Nano, Nature Communications, Molecular Therapy, Biomaterials, Journal of Controlled Release, and Advanced Materials. She is also a passionate science communicator and runs a TikTok channel dedicated to educating the public about RNA biotechnology, which now has >250,000 followers and >18M views.

     

    Dr. Blakney has received numerous awards and recognitions in addition to the Tier 2 Canada Research Chair in Nucleic Acid Bioengineering, including the 2023 MIT Tech Review’s 35 Innovators Under 35, 2022 Gairdner Early Career Investigator Award, the 2021 UBC President’s Award for Public Education Through Media and the 2022 Controlled Release Society Gene Delivery and Editing Focus Group Young Investigator Award.



  • Professor, Nagoya University, JapanHiroshi Abe,
    Hiroshi Abe,
    Professor, Nagoya University, Japan

    2015- Present     Professor, Nagoya University University, Japan

    2013-2015         Associate Professor, Hokkaido University, Japan

    2005-2013         Researcher, RIKEN, Japan

    2002-2005         Prof. Eric Kool, Stanford University, USA

    2001-2002         Prof. Joaane Stubbe, Massachusetts Institute Technology, USA

    2001 PhD          Hokkaido University

    1998 MS           Hokkaido University

    1996 BS            Hokkaido University

    Research Interests:

    Chemical Biology of Nucleic Acids, RNA therapeutics


  • Assistant Professor, University of Toronto, CanadaBowen Li,
    Bowen Li,
    Assistant Professor, University of Toronto, Canada

    Dr. Bowen Li is a tenure-track Assistant Professor in the Leslie Dan Faculty of Pharmacy and Institute of Biomedical Engineering at the University of Toronto, and an Affiliate Scientist at Princess Margaret Cancer Centre. He is also a holder of the Canada Research Chair in RNA Vaccines and Therapeutics (Tier 2), and the GSK Chair in Pharmaceutics and Drug Delivery. Dr. Li received his Ph.D. in Bioengineering from the University of Washington-Seattle (Supervisor: Shaoyi Jiang), and then completed a Postdoc Fellowship in the Koch Institute for Integrative Cancer Research at MIT (Supervisors: Robert Langer and Daniel Anderson). His lab utilizes a range of interdisciplinary strategies, including combinatorial chemistry, high throughput platforms, and AI-driven design of experiments, to develop new generations of delivery systems for RNA medicines. He has published over 40 peer-reviewed publications in top-tier journals, including Nature Biotechnology, Nature Biomed. Eng., Nature Materials and Nature Medicine, and filed eight patents. His research in preclinical RNA-based drug development has been recognized with multiple awards, including the Canadian Society for Pharmaceutical Sciences Early Career Award, ACS Rising Star in Biological, Medicinal, and Pharmaceutical Chemistry, CF Canada Marsha Morton Early Career Investigator Award, Gairdner Early Career Investigator Award etc.


  • Project Manager, University of Sheffield, UKMabrouka Maamra
    Mabrouka Maamra
    Project Manager, University of Sheffield, UK

    "I earned a Nature Sciences degree at the “Universite Paris XII “, a Master in technical

    Sciences and Techniques in Chemistry applied to Biology. My PhD was in molecular

    Endocrinology at the University of Sheffield. As a postdoctoral scientist, I worked on

    developing therapeutics for endocrine and kidney diseases using a wide range of

    molecular/cellular and animal models. In 2023, I joined Dr Zoltan Kis ‘s team working on the

    development and modelling of rapid-response vaccine production platform technologies

    funded by the Wellcome R3 program as a project manager. This work is addressing the

    challenge of producing large volumes of vaccines, rapidly, at high quality and at low cost for

    pandemic response, using experimental and modelling resources.

  • CTO, NeoVAC, UKHeinrich Haas
    Heinrich Haas
    CTO, NeoVAC, UK

    Heinrich Haas, Department of Biopharmaceutics and Pharmaceutical Technology Johannes Gutenberg-Universität, Mainz Mainz, Germany. Ph.D. in the group of Prof. Dr. Helmuth Möhwald at Johannes-Gutenberg Universität Mainz. Researched lipid membranes and organized bio-molecular systems. In pharmaceutical industry (Munich Biotech, Medigene, BioNTech) developed different types of nanoparticle products to clinical stage. Focus on advanced approaches for nanoparticle development and control.

  • Deputy Director, R&D Strategy, Nucleic Acid Therapeutics Initiative, SingaporeSissi Lin
    Sissi Lin
    Deputy Director, R&D Strategy, Nucleic Acid Therapeutics Initiative, Singapore

    Dr. Sissi Lin is an organic chemist with over 15 years of specialized experience in nucleic acid chemistry and RNA drug development. Her career includes serving  as the founding director of Chemistry and Operations at Lerna Biopharma, a Singapore-based biotech company, where she spearheaded the development of oligonucleotide drug technologies and managed CMC for preclinical candidates. Dr. Lin has also served as Vice President and Advisor at Biotech Connection Singapore, where she played an active role in strengthening Singapore's biotech ecosystem. She has been featured at numerous conferences focused on RNA drug development and the biotech sector as a speaker and panelist. Currently, Dr. Lin is the Deputy Director at the Nucleic Acid Therapeutics Initiative, Singapore’s national platform for RNA drug development, where she directs R&D strategy and drives innovations in therapeutic solutions.

  • Founder, CSO&COO, Arcturus Therapeutics, USAPad Chivukula
    Pad Chivukula
    Founder, CSO&COO, Arcturus Therapeutics, USA

    Dr. Pad Chivukula, Ph.D. is the Chief Scientific Officer and Chief Operating Officer at Arcturus Therapeutics. With a rich foundation in nanoparticle technology, Dr. Chivukula expertly guides Arcturus’ efforts in discovering and developing transformative medicines for serious diseases. Since co-founding Arcturus with Joseph Payne in 2013, he has significantly advanced the company’s research capabilities and pipeline, focusing on RNA therapies and vaccines.

    Under his leadership, the R&D organization thrives on a culture of urgency to meet patient needs, integrating advanced therapeutic platforms and streamlining processes. His prior experience includes a significant tenure at Nitto, where he was a Group Leader and Chief Scientist, and led the polymeric RNAi research department. Dr. Chivukula holds a Ph.D. in Pharmaceutical Chemistry from the University of Utah, specializing in nanoparticle technology.


  • COB&CSO, Nanjing AuroRNA BiotechnologyYing Mazzu
    Ying Mazzu
    COB&CSO, Nanjing AuroRNA Biotechnology

    张莹拥有超过20年的药物化学,细胞分子生物学、癌症生物学、免疫肿瘤学和临床数据生物信息学等领域的研发实践经验,深耕癌症新型疗法开发领域。曾在美国麻省大学医学院进行博士后研究,后在美国纪念斯隆凯瑟琳癌症研究中心任职资深研究员,获得多个美国国家级项目支持,发表多篇国际论文,获得国际专利。2022年回国,入选“江苏省百人外专”,获得“南京市紫金山英才计划”项目资助。现担任远大医药奥罗生物董事长兼CSO.

  • CEO, Starna Therapeutics, ChinaFrank Hu
    Frank Hu
    CEO, Starna Therapeutics, China

    Dr. Rongkuan Hu is the founder and CEO of Starna Therapeutics and also holds the position of Industrial Professor at the College of Biomedical Engineering of USTC and the School of Pharmacy at Soochow University.


    Prior to his role at Starna Therapeutics, Dr. Hu held various management roles in pharmaceutical and biotech companies. Under his leadership, numerous mRNA and siRNA projects transitioned into clinical trials and achieved commercial milestones. Dr. Hu has authored over 50 patents and peer-reviewed SCI papers in the field of RNA therapy. He obtained his doctoral degree from USTC, an Executive MBA from CEIBS, and conducted postdoctoral research at UT Southwestern Medical Center.


  • Professor, Hangzhou  Institute of Medicine, CASXiaolin Li
    Xiaolin Li
    Professor, Hangzhou Institute of Medicine, CAS

    Xiaolin Andy Li, Chief AI Scientist, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences (CAS), President of Industry-University Research Alliance for Knowledge Federation (AKF). He was a tenured full professor at University of Florida, Division Chair of Computer Engineering, founding director of NSF Center for Big Learning (CBL), the first national deep learning center in USA with colleagues at UF, CMU, UO, and UMKC along with over 30 leading industry members (such as Google, Nvidia, Baidu, Tencent etc). He was awarded NSF CAREER Award, China Top 10 AI Leaders, several best papers, and contest winning teams. He led the team to develop early AI platforms and algorithms (CognitiveEngine/DeepCloud, PrimateAI/DeepFolding/FoldingZero, DeepBipolar/DeepCancer, DeepAtom/DyScore/DrugMetric, MySurgeryRisk, iBond/FLEX,BatmanNet/AptaDiff/RNADiff/AtomicFold). He has published about 200 papers in deep learning, biopharma technology, cloud computing, and security&privacy. His research findings have been applied in drug target discovery, protein folding, RNA/DNA folding, drug design, virtual screening, omics, and clinical decision support systems. Several of his students have become tenured or tenure-track professors in USA (including one in Top Five College of Pharmacy).


  • CSO China, Immorna BiotherapeuticsYuanqing Liu
    Yuanqing Liu
    CSO China, Immorna Biotherapeutics

    Dr. Liu Yuanqing graduated from Shanghai Medical College of Fudan University and was a surgeon at Shanghai Zhongshan Hospital. He completed his PhD in Vrije Universiteit Brussel in Belgium and was one of the pioneers on myeloid-derived suppressors in tumors. He was previously a senior research lead at Sanofi Pasteur French headquarter, where he contributed to various vaccine projects, including cancer vaccines, vaccines against infectious diseases, pediatric vaccines, adjuvants, etc. Dr. Liu is an industry veteran with extensive experience in the development of innovative vaccines for international market. He was a member of the EU Innovative Medicine Initiative. Since 2021, he has been the Chief Scientific Officer of Immorna Biotechnology. He is based in Shanghai where Immorna has established a high-standard R&D site aiming to accelerate the development of mRNA vaccines and drugs in China.

  • Vice President of Formulation, Abogen BiosciencesJerry Zhang
    Jerry Zhang
    Vice President of Formulation, Abogen Biosciences

    Jerry Zhang joined the Suzhou Abogen Biosciences in May of 2020 and currently serves as the Vice President of Formulation leading the formulation, process development and tech transfer of mRNA-LNP products.

     

    Dr. Zhang has 23 years of experiences in formulation development of sterile parenteral drug products including various complex injectables such as lipid nanoparticles, liposomes, nanoemulsions, polymeric nanoparticles and nanocrystal suspensions as well as lyophilized powders. Prior to joining Abogen, he worked for Hospira (now Pfizer), Daiichi Sankyo and Livzon Pharmaceutical Group as a Senior Research Pharmacist, Supervisor of  Formulation R & D and Senior Director of Formulation, respectively. He also worked on mRNA-LNP formulations at Shire Human Genetic Therapies (now Takeda) and Arcturus Therapeutics to support preclinical studies.

     

    Dr. Zhang holds a PhD in Bioorganic Chemistry from Kyushu University, a MS in Organic Chemistry and a BS in Chemistry from Fudan University. He completed his postdoctoral training at University of Notre Dame and Purdue University in liposome-based systems for triggered release and targeted delivery.


  • Professor, Shanghai Jiaotong University, ChinaXueqing Zhang,
    Xueqing Zhang,
    Professor, Shanghai Jiaotong University, China

    Dr. Xue-Qing Zhang is a Ph.D. advisor at the School of Pharmacy, Shanghai Jiao Tong University. She earned her Ph.D. in Polymer Chemistry and Physics from Wuhan University. In 2010, she joined the research groups of Professor Robert Langer at MIT and Professor Omid Farokhzad at Harvard Medical School in 2010, where she completed the joint postdoctoral training. Following this, she worked for several years in formulation development at a U.S. biopharmaceutical company. Her research focuses on nucleic acid delivery systems and biomedical materials, driven by clinical needs. Specifically, she explores (i) novel mRNA vaccines and their applications in infectious disease prevention, and (ii) targeted nucleic acid nanodelivery systems for treating organ fibrosis, cancer, and cardiovascular diseases, along with the underlying mechanisms. She has published more than 50 SCI papers in journals such as Science Advances, Nature Communications, ACS Nano, and PNAS, with over 8,000 citations. She holds multiple patents, including two granted in the U.S. and eight in China. Her work has gained significant attention and citations both domestically and internationally in the research field of polymer- and lipid-based RNA delivery systems, and has been featured by the Ministry of Science and Technology of China, Polymer Science, ACS Nano, and other media outlets. Dr. Zhang has led several key projects, including the National Biopharmaceutical Technology Innovation Center’s nucleic acid drug development initiative and the "Key Technology Research in Biosafety" project under the National Key R&D Program. She has been recognized by numerous talent programs, including the National High-level Talent Introduction Program for Young Professionals, the Shanghai Pearl Peak Talent, and Program for Innovation and Entrepreneurship Talents in Jiangsu Province. Additionally, she has been invited to serve as a member of the editorial board for the Higher Education Press’s "14th Five-Year Plan" medical textbook Introduction to Pharmacy, the Editorial Board of Drug Regulatory Science and Modern Pharmaceutical Management, and as a technical advisor to the Shanghai Institute of Biological Products.


  • General Manager, Shanghai Wotai Biotechnology, ChinaAndrew Wong
    Andrew Wong
    General Manager, Shanghai Wotai Biotechnology, China

    Andrew Wong is General Manager of Shanghai Wotai Biotechnology Co., Ltd., a subsidiary company of Walvax Biotechnology Co., Ltd., a public listed and leading vaccine development, and manufacturing company in China, where Andrew held a position as Director of Business Development until recently. Andrew had managed Walvax's global business activities including product global registration, sales & marketing, tech-transfer and licensing-in/out for more than 4 years till August 2024.. 

    By participating in Walvax’s efforts to become a global vaccine manufacturer, between September 2015 and March 2020, Andrew managed a three collaboration projects under a combined sum of USD 8.5 million funding from the Bill and Melinda Gates Foundation to support the development of bivalent, nona-valent HPV vaccines and recombinant COVID-19 vaccine for developing countries. Representing Walvax, Andrew participated in the efforts with Shanghai Zerun Biotechnology Co., Ltd, a Walvax subsidiary in Shanghai, to secure grants more than USD 20 millions from CEPI to support the preclinical and clinical development of the variant recombinant COVID-19 vaccine.  Currently, Andrew leads his teams to work on Walvax’s global business expansion through licensing-in/out and international product registration and distribution.

    After academic trainings from China, Canada and United States in clinical medicine, immunology, molecular biology,  and business administration with an MBA from UCLA Anderson School, Andrew Wong, MD, MBA has almost three decades’ experiences in biopharmaceutical research, business development and general management, including close to 12 years’ work experience at the world’s largest biotech company - Amgen Inc. in USA, by engaging in recombinant antibody therapeutics and anticancer small molecule drug research and development.


  • Co-founder & CSO , Hanz Biotechnology (Suzhou)Xuexiang Han
    Xuexiang Han
    Co-founder & CSO , Hanz Biotechnology (Suzhou)

    韩雪祥教授,中科院分子细胞科学卓越创新中心研究员,课题组长,博士生导师。

    入选国家级高层次人才(海外)项目和上海市领军人才(海外)项目。

    汉信生物科技(苏州)有限公司,联合创始人&首席科学家。

    2014年本科毕业于上海大学、2019年博士毕业于清华大学(国家纳米科学中心联合培养);2020-2024年在美国宾夕法尼亚大学Michael J. Mitchell教授实验室从事博士后研究工作,期间与诺奖得主Drew Weissman教授合作开展LNP-mRNA疫苗和药物的研究;2024年2月入职中科院分子细胞科学卓越创新中心。主要研究方向为新型LNP的构建和RNA药物递送,以第一(含共一)作者在Nat. Chem.、Nat. Nanotech.、Nat. Mater.、Nat. Commun.等期刊发表论文近20篇,授权中国专利一项,申请PCT专利多项。


  • Leading Scientist & CSO Academic Secretary, CNBG- Virogin Biotech, ChinaWenshuo Zhou
    Wenshuo Zhou
    Leading Scientist & CSO Academic Secretary, CNBG- Virogin Biotech, China

    博士毕业于美国弗吉尼亚州的欧道明大学,主攻方向为Vector-Borne disease中黄热病毒属(LGTV,ZIKV, DENV等病毒)依靠外泌体进行体内体外感染传播的机理研究并将成果发表在多个高影响因子杂志上(PNAS, EMI, PLoS Pathogen等)。

    后在美国食品药品监督管理局FDA,CBER下设的疫苗评审研究办公室OVRR担任白橡树外国科学家项目博士后研究员(ORISE Fellow)从事以减毒风疹病毒为载体对新冠S蛋白,RSV或HIV相关蛋白表达的重组载体疫苗的研发工作。

    目前在国药中生集团旗下的子公司中生复诺健生物科技有限公司担任资深科学家和学术秘书,负责多条传染病mRNA疫苗管线的早期研发和相关学术会议组织和讨论工作。


  • Executive Director at A*STAR Bioprocessing Technology Institute, SingaporeBoon Tong Koh
    Boon Tong Koh
    Executive Director at A*STAR Bioprocessing Technology Institute, Singapore

    Boon Tong joined A*STAR as Executive Director of BTI on 3 May 2021 and was concurrently appointed ED of Nucleic Acid Therapeutic Initiative in October 2023. With over 30 years of experience in the private sector, he had managed specialty chemicals, API operations and businesses in China and India. He comes onboard with deep expertise in managing translational research teams, pharmaceutical operations, and businesses across Asia. He further possesses extensive knowledge in GMP operations encompassing research, pilot, and manufacturing, through prominent roles at GSK and Lonza. Boon Tong graduated with a PhD from the National University of Singapore and is Adjunct Professor at Singapore Institute of Technology (SIT).

  • R&D Director, Beijing Intell NanomedicineJiajia Zou
    Jiajia Zou
    R&D Director, Beijing Intell Nanomedicine

    Jiajia Zou, the Research and Development (R&D) director at Beijing Intell Nanomedicine, earned her doctorate from the University of Glasgow. With seven years of expertise in DNA nanotechnology, she has dedicated three years to advancing the industrialization of DNA nanomaterials, overseeing the development of structural assembly, mass production, and non-clinical projects.

  • 活动日程
    2024-09-11
    2024-09-12
    2024-09-11
    09:00 -18:30
    A
    2024-09-11
    09:00-09:30
    癌症中的RNA可变剪接
    嘉宾
    RNA World 2024
    Chonghui Cheng
    Professor, Baylor College of Medicine, USA
    2024-09-11
    09:30-10:00
    利用计算算法优化RNA设计
    嘉宾
    RNA World 2024
    Liang Huang
    Professor, Oregan State University, USA
    2024-09-11
    10:00-10:30
    基于环状RNA的体内原位CAR协同免疫治疗技术

    Chimeric Antigen Receptor (CAR) T cell therapy has shown promise in treating hematologic malignancies. However, it is limited to individualized cell therapy and faces challenges, including high costs, extended preparation time, and limited efficacy against solid tumors. Here, we generated circular RNAs (circRNAs) encoding Chimeric Antigen Receptor (CAR) transmembrane proteins, referred to as circRNA-CAR, which mediated remarkable tumor killing in both T cells and macrophages. In addition, macrophages exhibited efficient phagocytosis of tumor cells and pro-inflammatory polarization induced by circRNA-CAR in vitro. We demonstrated that circRNA-CAR, delivered with immunocyte-tropic lipid nanoparticles (LNPs), significantly inhibited tumor growth, improved survival rates and induced a pro-inflammatory tumor microenvironment in mice. Importantly, the combination of circRNA-Anti-HER2-CAR and circRNA-based cancer vaccines encoding the corresponding transmembrane HER2 antigen, termed circRNA-HER2, exhibited synergistically enhanced anti-tumor activity. This proof-of-concept study demonstrated that the combination of circRNA-based in vivo CAR and vaccines, termed in vivo CAR-VAC, holds the potential to become an upgraded off-the-shelf immunotherapy.



    嘉宾
    RNA World 2024
    Liang Qu
    Professor, Fudan University
    2024-09-11
    10:45-11:15
    RNAi疗法的潜力

    siRNAs represent a new class of therapeutic modality enabling sequence-specific and sustained gene silencing through the post-tranional gene regulation mechanism known as RNAi. Recent advances in the chemical evolution of therapeutic RNAs have brought this class of medicines to the clinic, demonstrating unprecedented clinical efficacy and productivity, marking a new era of pharmaceutical development.

     

    The following topics will be covered in this talk:

    ·         The brief history of RNAi: from fundamental biology to clinic utility

    ·         Principle considerations of therapeutic siRNA design

    ·         Recent advances in siRNA delivery technologies

    ·         Future directions of RNAi-based pharmaceutical development


    嘉宾
    RNA World 2024
    Qi Tang
    Postdoctoral Fellow, RNA Therapeutics Institute, USA
    2024-09-11
    11:15-11:40
    EB病毒相关B细胞淋巴瘤中的MicroRNAs和免疫检查点失调

    Epstein-Barr Virus (EBV)-associated B-cell lymphoma is a type of cancer characterized by the malignant transformation of B lymphocytes, often linked to immune system dysregulation. In EBV-associated B-cell lymphoma, specific miRNAs are dysregulated, disrupting immune checkpoints and impairing the immune system's ability to target cancer cells. This dysregulation promotes tumor growth and immune evasion. Understanding miRNA-immune checkpoint interactions could lead to new therapies to restore immune function and improve outcomes for patients.

    嘉宾
    RNA World 2024
    Eleni Anastasiadou,
    Assistant Professor, Sapienza University of Rome, Italy
    2024-09-11
    11:40-12:05
    下一代基因沉默

    -Current situation in siRNA development

    - Innovative covalent Delivery molecules for silencing beyond the liver

    - PRAMO´s development strategy


    嘉宾
    RNA World 2024
    Merle Fuchs
    Managing Partner& CEO,PRAMOMOLECULAR, Germany
    2024-09-11
    12:05-12:30
    siRNA治疗药物研发的综合方法
    嘉宾
    RNA World 2024
    Charles Tong
    Executive VP, Suzhou Ribo Life Science
    2024-09-11
    13:30-14:30
    下一代RNA疫苗与疗法

    -Intro to self-amplifying RNA

    -State of the field and challenges

    -Recent results on novel self-amplifying RNA designs


    嘉宾
    RNA World 2024
    Anna Blakney,
    Assistant Professor, University of British Columbia, Canada
    2024-09-11
    14:00-14:30
    基于化学的mRNA设计以提高转化效率
    嘉宾
    RNA World 2024
    Hiroshi Abe,
    Professor, Nagoya University, Japan
    2024-09-11
    14:30-15:00
    AI引导的自驱动实验室加速LNPs用于mRNA递送的发现
    嘉宾
    RNA World 2024
    Bowen Li,
    Assistant Professor, University of Toronto, Canada
    2024-09-11
    15:30-16:00
    质量设计辅助的下一代mRNA疫苗和治疗产品生产
    嘉宾
    RNA World 2024
    Mabrouka Maamra
    Project Manager, University of Sheffield, UK
    2024-09-11
    16:00-16:30
    下一代mRNA疫苗及药物开发的多功能技术平台
    嘉宾
    RNA World 2024
    Heinrich Haas
    CTO, NeoVAC, UK
    2024-09-11
    16:30-17:00
    解锁靶向递送RNA疗法的临床潜力

    -       An overview of targeted deliveries for RNA therapeutics

    -       An introduction of Nucleic Acid Therapeutics Initiative in Singapore


    嘉宾
    RNA World 2024
    Sissi Lin
    Deputy Director, R&D Strategy, Nucleic Acid Therapeutics Initiative, Singapore
    2024-09-12
    09:00 -17:00
    A
    2024-09-12
    09:00-09:30
    mRNA疫苗与疗法的开发
    嘉宾
    RNA World 2024
    Pad Chivukula
    Founder, CSO&COO, Arcturus Therapeutics, USA
    2024-09-12
    09:30-10:00
    针对HPV16阳性癌症的mRNA治疗性疫苗开发
    嘉宾
    RNA World 2024
    Ying Mazzu
    COB&CSO, Nanjing AuroRNA Biotechnology
    2024-09-12
    10:00-10:30
    RSA mRNA疫苗的开发及应用
    嘉宾
    RNA World 2024
    Frank Hu
    CEO, Starna Therapeutics, China
    2024-09-12
    11:00-11:30
    AI赋能的癌症疫苗开发

    As one of the most effective solutions in fighting against cancers, cancer vaccine is confronted with both huge potentials and overwhelming challenges. Artificial intelligence has been applied in the pipeline of cancer vaccine in an ad hoc manner. We are dedicated to creating an efficient and effective pipeline in an orchestrated whole-system design manner to overcome the numerous obstacles. We hope to pave a way to open more collaboration opportunities with the community to boost the development and clinical trials of cancer vaccine solutions. We are also actively recruiting talents to join us to make a difference together

    嘉宾
    RNA World 2024
    Xiaolin Li
    Professor, Hangzhou Institute of Medicine, CAS
    2024-09-12
    11:30-12:00
    系统递送自复制RNA编码IL-12 (JCXH-211-IV)治疗实体瘤

    IL-12 plays an important role in innate and adaptive immunity against cancers. Despite consistently showing potent antitumor activity in preclinical studies, a key challenge for IL-12 treatment is to achieve the non-overlap of tolerability window and therapeutic window. JCXH-211 is a first-in-class lipid nanoparticle (LNP) encapsulated srRNA, using Immorna's proprietary technology, encoding the engineered human IL-12 protein. Thanks to the intrinsic feature of srRNA, JCXH-211 intravenous (IV) administration enables a prolonged expression of IL-12 preferentially in tumor tissues rather than normal tissues, leading to modulation of tumor microenvironment and activation of antitumor immune responses, while minimizing systemic toxicity. In multiple preclinical studies including the patient-derived xenograft (PDX) models, JCXH-211 showed superior tumor-eradicating potency. Interim data from the Phase I trial of JCXH-211 intratumoral administration demonstrated excellent safety and tolerability and significant anti-tumor biological activity. JCXH-211-IV demonstrated good safety in nonclinical studies and has received the clearance from the FDA for a Phase 1/2 trial in patients with malignant solid tumors.

    嘉宾
    RNA World 2024
    Yuanqing Liu
    CSO China, Immorna Biotherapeutics
    2024-09-12
    12:00-12:30
    热稳定型mRNA-LNP产品的制剂开发进展
    嘉宾
    RNA World 2024
    Jerry Zhang
    Vice President of Formulation, Abogen Biosciences
    2024-09-12
    13:30-14:00
    脂质纳米载体的设计及RNA药物开发的探索

    Nucleic acid drugs achieve disease prevention or treatment by regulating the expression of target genes. They offer high specificity and efficacy, holding great potential to overcome the limitations of current druggable targets and to treat "undruggable" and "non-targetable" diseases. The challenges include: (1) the need for efficient and safe delivery vectors; and (2) the development of non-hepatic, organ/cell-specific targeting delivery systems to fully unleash the potential of nucleic acid drugs. This presentation focuses on inhalable nucleic acid delivery systems, including the advantages of local versus systemic administration, introduction of the biological barriers that must be overcome for pulmonary delivery via inhalation, and our recent research progress in the development of inhalable nucleic acid nanodelivery systems.

    Pulmonary fibrosis is an area with significant unmet clinical and market needs. We are developing an inhalable nucleic acid nanodrug for the treatment of pulmonary fibrosis, covering its design and characterization, in vivo tissue distribution, antifibrotic efficacy evaluation, and safety assessment. This safe and effective inhalable nucleic acid nanodelivery technology also provides a platform for the development of new drugs for various respiratory diseases.


    嘉宾
    RNA World 2024
    Xueqing Zhang,
    Professor, Shanghai Jiaotong University, China
    2024-09-12
    14:00-14:30
    单价XBB.1.5 mRNA疫苗的开发

    Introduce Wavlax’s Development of a monovalent XBB.1.5 mRNA      Vaccine in China

    Implication of Walvax’s mRNA vaccine technology platform for      future vaccine development


    嘉宾
    RNA World 2024
    Andrew Wong
    General Manager, Shanghai Wotai Biotechnology, China
    2024-09-12
    14:30-15:00
    合理设计可电离脂质和RNA药物递送

    1) Progress of ionizable lipids

    2) Rational design of ionizable lipids

    3) lonizable lipid RNA drug delivery applications

    4) Future of ionizable lipids


    嘉宾
    RNA World 2024
    Xuexiang Han
    Co-founder & CSO , Hanz Biotechnology (Suzhou)
    2024-09-12
    15:15-15:45
    新加坡mRNA的初生

    Singapore’s mRNA initiative leverages on the broader S$97million national Nucleic Acid Therapeutics Initiative (NATi) launched in 2024, and Singapore’s strong base of bio manufacturing research and innovation capabilities, anchored by the Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR). In 2024, BTI was awarded funding by NATi to set up an mRNA foundry, which would (i) enable scalable, high quality end-to-end manufacturing of mRNA products for translation towards preclinical trials, (ii) drive development of innovative next-generation manufacturing technologies and processes, and (iii) facilitate transition to manufacturing in cGMP environment. Singapore’s mRNA initiative will support translation of mRNA assets from public and private sector and advance the mRNA manufacturing sector in Singapore, positioning Singapore as a regional hub for research, clinical translation, and commercialisation of RNA drugs and vaccines.

    嘉宾
    RNA World 2024
    Boon Tong Koh
    Executive Director at A*STAR Bioprocessing Technology Institute, Singapore
    2024-09-12
    15:45-16:15
    结核病抗原mRNA疫苗的全面筛查在多种动物模型中诱导了强烈的免疫反应
    嘉宾
    RNA World 2024
    Wenshuo Zhou
    Leading Scientist & CSO Academic Secretary, CNBG- Virogin Biotech, China
    2024-09-12
    16:15-16:30
    基于DNA纳米颗粒平台的SiRNA递送
    嘉宾
    RNA World 2024
    Jiajia Zou
    R&D Director, Beijing Intell Nanomedicine
    癌症中的RNA可变剪接
    RNA World 2024
    Chonghui Cheng
    Professor, Baylor College of Medicine, USA

    Dr. Chonghui Cheng is currently a Professor at Baylor College of Medicine in Houston, Texas, USA. She obtained a PhD from Sloan Kettering Institute/Cornell University working with Dr. Stewart Shuman and conducted postdoctoral training at MIT under Nobel Laureate Dr. Phillip Sharp. In 2007, Dr. Cheng joined the faculty at Northwestern University. In 2016, she was recruited to Baylor College of Medicine as a CPRIT Rising-Star Scholar. Dr Cheng has made major contributions to the understanding of alternative splicing in cancer. Her laboratory investigates the fundamental questions of how RNA regulation controls cellular processes in normal biology and in the context of cancer. Working at the interface of RNA splicing and breast cancer biology, Dr. Cheng’s research pioneered the findings that splice isoform switching causally controls epithelial-mesenchymal transition (EMT) and breast cancer metastasis. The research team in Dr. Cheng’s laboratory combines multidisciplinary approaches of molecular biology, genetics, and bioinformatics and aims to discover rules and networks of RNA binding proteins and alternative splicing that regulate breast cancer metastasis and to advance the development of novel therapeutics for the treatment of this deadly disease.


    利用计算算法优化RNA设计
    RNA World 2024
    Liang Huang
    Professor, Oregan State University, USA

    Liang Huang (PhD, Penn, 2008) is a Professor of Computer Science at Oregon State University, and co-founder of Coderna.ai. Until recently, he was also a Distinguished Scientist at Baidu Research USA. He also worked at Google Research, USC, and City Univ. of New York. He was a leading natural natural language processing (NLP) researcher, but in recent years, he has shifted his attention to applying these natural language algorithms to computational biology, esp. RNA folding and RNA design, with the hope of fighting COVID. This line of linguistics-inspired biology work eventually led to PNAS (2021) and Nature (2023) papers, and is widely covered in the media.

    基于环状RNA的体内原位CAR协同免疫治疗技术
    RNA World 2024
    Liang Qu
    Professor, Fudan University

    璩良, 复旦大学基础医学院研究员、博士生导师、课题组长。2022年入职复旦大学基础医学院,组建RNA疫苗技术与免疫治疗实验室,致力于新型RNA疫苗及治疗技术开发与免疫治疗研究。璩良博士开发了不依赖CRISPR/Cas系统的RNA编辑技术—LEAPER(Nature Biotechnology,2019)及其迭代升级版LEAPER2.0(Nature Biotechnology,2022),入选《国家十三五科技创新成就展》;国际上首次报道circRNA疫苗技术平台、拓展了RNA治疗技术新领域(Cell,2022);获吴瑞纪念基金会吴瑞奖(2020)、入选国家博新计划(2020)和上海市晨光计划(2023);主持科技部国家重点研发计划课题(2023,核糖核酸底层技术研发)和上海市科委合成生物学重点专项(2023,新型RNA疫苗/治疗技术的开发)等项目支持。

    RNAi疗法的潜力
    RNA World 2024
    Qi Tang
    Postdoctoral Fellow, RNA Therapeutics Institute, USA

    Qi received his PhD in Pharmaceutical Sciences with a specialization in chemical biology of nucleic acids from the University of Rhode Island in 2019. He is currently a postdoctoral fellow in the Anastasia Khvorova Lab at the RNA Therapeutics Institute, where he is working on engineering small-interfering RNAs to address unmet needs in the treatment of inflammatory disorders. He has recently led the design of an immunomodulatory JAK1-selective siRNA, and the investigational drug is licensed to Aldena Therapeutics and is currently under clinical development for treating inflammatory skin diseases. Qi is a recipient of the 2023 NIH K99/R00 Pathway to Independence Award and is establishing his lab at the University of Massachusetts Chan Medical School with a primary focus on chemical biology and preclinical development of therapeutic RNAs.


    EB病毒相关B细胞淋巴瘤中的MicroRNAs和免疫检查点失调
    RNA World 2024
    Eleni Anastasiadou,
    Assistant Professor, Sapienza University of Rome, Italy

    Eleni Anastasiadou received her Ph.D. from La Sapienza, University of Rome, Italy, specializing in microbiology and virology. She focused on the interactions of cellular miRNAs with Epstein Barr Virus latent proteins in lymphoma. Her pioneering work led to the identification of how viral proteins subvert cellular miRNAs and contribute to cancer. During her work at Beth Israel Deaconess Medical Center/Harvard Medical School, Boston has developed an RNA-aided cancer immunotherapy method and a bench-to-bedside delivery of miRNAs in lymphomas. Currently, she is an Assistant Professor at La Sapienza University, focused on the role of miRNAs in regulating immune responses in cancer.


    下一代基因沉默
    RNA World 2024
    Merle Fuchs
    Managing Partner& CEO,PRAMOMOLECULAR, Germany

    Merle Fuchs is Co-Founder and CEO of PRAMOMOLECULAR GmbH, a biotech startup based in Berlin. PRAMOMOLECULAR develops therapeutics based on short interfering RNAs (siRNAs) to downregulate oncoproteins in lung, pancreas, and skin. She benefits from her scientific background as a micro- and molecular biologist as well as from her previous experience in setting up “TechnologieContor”, a consulting company for high-tech start-ups and innovative grown-ups with a focus on business development and financing. Merle Fuchs is Co-Founder of seven other high-tech startups.

    siRNA治疗药物研发的综合方法
    RNA World 2024
    Charles Tong
    Executive VP, Suzhou Ribo Life Science

    Charles C. Tong, Ph.D., Executive Vice President and Head of R&D Center, has been engaged in the oligonucleotide therapeutics research and development at Suzhou Ribo Life Science since 2016. He has more than 27 years of extensive working experience in the pharmaceutical industry, including various scientific and leadership roles in R&D organizations in pharma and biotechnology companies to advance products from preclinical research, clinical development to market authorization. Prior to his current position, he served as General Manager of R&D Center at Hisun-Pfizer Pharmaceuticals, Senior Director of Pharmaceutical Sciences at Pfizer Inc., as well as Chair of International Society for Pharmaceutical Engineering (ISPE) China.


    下一代RNA疫苗与疗法
    RNA World 2024
    Anna Blakney,
    Assistant Professor, University of British Columbia, Canada

    Dr. Blakney is an Assistant Professor and Tier 2 Canada Research Chair in the Michael Smith Laboratories and School of Biomedical Engineering at UBC. She received her Bachelor of Science in Chemical & Biological Engineering from the University of Colorado at Boulder, and her PhD in Bioengineering from the University of Washington. She completed a postdoctoral fellowship at Imperial College London on the development of molecular and biomaterial engineering strategies for delivery of self-amplifying RNA. Her lab uses bioengineering, molecular biology and immunology approaches to develop the next generation of RNA vaccines and therapies. Her research has been published in a variety of top tier journals including ACS Nano, Nature Communications, Molecular Therapy, Biomaterials, Journal of Controlled Release, and Advanced Materials. She is also a passionate science communicator and runs a TikTok channel dedicated to educating the public about RNA biotechnology, which now has >250,000 followers and >18M views.

     

    Dr. Blakney has received numerous awards and recognitions in addition to the Tier 2 Canada Research Chair in Nucleic Acid Bioengineering, including the 2023 MIT Tech Review’s 35 Innovators Under 35, 2022 Gairdner Early Career Investigator Award, the 2021 UBC President’s Award for Public Education Through Media and the 2022 Controlled Release Society Gene Delivery and Editing Focus Group Young Investigator Award.



    基于化学的mRNA设计以提高转化效率
    RNA World 2024
    Hiroshi Abe,
    Professor, Nagoya University, Japan

    2015- Present     Professor, Nagoya University University, Japan

    2013-2015         Associate Professor, Hokkaido University, Japan

    2005-2013         Researcher, RIKEN, Japan

    2002-2005         Prof. Eric Kool, Stanford University, USA

    2001-2002         Prof. Joaane Stubbe, Massachusetts Institute Technology, USA

    2001 PhD          Hokkaido University

    1998 MS           Hokkaido University

    1996 BS            Hokkaido University

    Research Interests:

    Chemical Biology of Nucleic Acids, RNA therapeutics


    AI引导的自驱动实验室加速LNPs用于mRNA递送的发现
    RNA World 2024
    Bowen Li,
    Assistant Professor, University of Toronto, Canada

    Dr. Bowen Li is a tenure-track Assistant Professor in the Leslie Dan Faculty of Pharmacy and Institute of Biomedical Engineering at the University of Toronto, and an Affiliate Scientist at Princess Margaret Cancer Centre. He is also a holder of the Canada Research Chair in RNA Vaccines and Therapeutics (Tier 2), and the GSK Chair in Pharmaceutics and Drug Delivery. Dr. Li received his Ph.D. in Bioengineering from the University of Washington-Seattle (Supervisor: Shaoyi Jiang), and then completed a Postdoc Fellowship in the Koch Institute for Integrative Cancer Research at MIT (Supervisors: Robert Langer and Daniel Anderson). His lab utilizes a range of interdisciplinary strategies, including combinatorial chemistry, high throughput platforms, and AI-driven design of experiments, to develop new generations of delivery systems for RNA medicines. He has published over 40 peer-reviewed publications in top-tier journals, including Nature Biotechnology, Nature Biomed. Eng., Nature Materials and Nature Medicine, and filed eight patents. His research in preclinical RNA-based drug development has been recognized with multiple awards, including the Canadian Society for Pharmaceutical Sciences Early Career Award, ACS Rising Star in Biological, Medicinal, and Pharmaceutical Chemistry, CF Canada Marsha Morton Early Career Investigator Award, Gairdner Early Career Investigator Award etc.


    质量设计辅助的下一代mRNA疫苗和治疗产品生产
    RNA World 2024
    Mabrouka Maamra
    Project Manager, University of Sheffield, UK

    "I earned a Nature Sciences degree at the “Universite Paris XII “, a Master in technical

    Sciences and Techniques in Chemistry applied to Biology. My PhD was in molecular

    Endocrinology at the University of Sheffield. As a postdoctoral scientist, I worked on

    developing therapeutics for endocrine and kidney diseases using a wide range of

    molecular/cellular and animal models. In 2023, I joined Dr Zoltan Kis ‘s team working on the

    development and modelling of rapid-response vaccine production platform technologies

    funded by the Wellcome R3 program as a project manager. This work is addressing the

    challenge of producing large volumes of vaccines, rapidly, at high quality and at low cost for

    pandemic response, using experimental and modelling resources.

    下一代mRNA疫苗及药物开发的多功能技术平台
    RNA World 2024
    Heinrich Haas
    CTO, NeoVAC, UK

    Heinrich Haas, Department of Biopharmaceutics and Pharmaceutical Technology Johannes Gutenberg-Universität, Mainz Mainz, Germany. Ph.D. in the group of Prof. Dr. Helmuth Möhwald at Johannes-Gutenberg Universität Mainz. Researched lipid membranes and organized bio-molecular systems. In pharmaceutical industry (Munich Biotech, Medigene, BioNTech) developed different types of nanoparticle products to clinical stage. Focus on advanced approaches for nanoparticle development and control.

    解锁靶向递送RNA疗法的临床潜力
    RNA World 2024
    Sissi Lin
    Deputy Director, R&D Strategy, Nucleic Acid Therapeutics Initiative, Singapore

    Dr. Sissi Lin is an organic chemist with over 15 years of specialized experience in nucleic acid chemistry and RNA drug development. Her career includes serving  as the founding director of Chemistry and Operations at Lerna Biopharma, a Singapore-based biotech company, where she spearheaded the development of oligonucleotide drug technologies and managed CMC for preclinical candidates. Dr. Lin has also served as Vice President and Advisor at Biotech Connection Singapore, where she played an active role in strengthening Singapore's biotech ecosystem. She has been featured at numerous conferences focused on RNA drug development and the biotech sector as a speaker and panelist. Currently, Dr. Lin is the Deputy Director at the Nucleic Acid Therapeutics Initiative, Singapore’s national platform for RNA drug development, where she directs R&D strategy and drives innovations in therapeutic solutions.

    mRNA疫苗与疗法的开发
    RNA World 2024
    Pad Chivukula
    Founder, CSO&COO, Arcturus Therapeutics, USA

    Dr. Pad Chivukula, Ph.D. is the Chief Scientific Officer and Chief Operating Officer at Arcturus Therapeutics. With a rich foundation in nanoparticle technology, Dr. Chivukula expertly guides Arcturus’ efforts in discovering and developing transformative medicines for serious diseases. Since co-founding Arcturus with Joseph Payne in 2013, he has significantly advanced the company’s research capabilities and pipeline, focusing on RNA therapies and vaccines.

    Under his leadership, the R&D organization thrives on a culture of urgency to meet patient needs, integrating advanced therapeutic platforms and streamlining processes. His prior experience includes a significant tenure at Nitto, where he was a Group Leader and Chief Scientist, and led the polymeric RNAi research department. Dr. Chivukula holds a Ph.D. in Pharmaceutical Chemistry from the University of Utah, specializing in nanoparticle technology.


    针对HPV16阳性癌症的mRNA治疗性疫苗开发
    RNA World 2024
    Ying Mazzu
    COB&CSO, Nanjing AuroRNA Biotechnology

    张莹拥有超过20年的药物化学,细胞分子生物学、癌症生物学、免疫肿瘤学和临床数据生物信息学等领域的研发实践经验,深耕癌症新型疗法开发领域。曾在美国麻省大学医学院进行博士后研究,后在美国纪念斯隆凯瑟琳癌症研究中心任职资深研究员,获得多个美国国家级项目支持,发表多篇国际论文,获得国际专利。2022年回国,入选“江苏省百人外专”,获得“南京市紫金山英才计划”项目资助。现担任远大医药奥罗生物董事长兼CSO.

    RSA mRNA疫苗的开发及应用
    RNA World 2024
    Frank Hu
    CEO, Starna Therapeutics, China

    Dr. Rongkuan Hu is the founder and CEO of Starna Therapeutics and also holds the position of Industrial Professor at the College of Biomedical Engineering of USTC and the School of Pharmacy at Soochow University.


    Prior to his role at Starna Therapeutics, Dr. Hu held various management roles in pharmaceutical and biotech companies. Under his leadership, numerous mRNA and siRNA projects transitioned into clinical trials and achieved commercial milestones. Dr. Hu has authored over 50 patents and peer-reviewed SCI papers in the field of RNA therapy. He obtained his doctoral degree from USTC, an Executive MBA from CEIBS, and conducted postdoctoral research at UT Southwestern Medical Center.


    AI赋能的癌症疫苗开发
    RNA World 2024
    Xiaolin Li
    Professor, Hangzhou Institute of Medicine, CAS

    Xiaolin Andy Li, Chief AI Scientist, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences (CAS), President of Industry-University Research Alliance for Knowledge Federation (AKF). He was a tenured full professor at University of Florida, Division Chair of Computer Engineering, founding director of NSF Center for Big Learning (CBL), the first national deep learning center in USA with colleagues at UF, CMU, UO, and UMKC along with over 30 leading industry members (such as Google, Nvidia, Baidu, Tencent etc). He was awarded NSF CAREER Award, China Top 10 AI Leaders, several best papers, and contest winning teams. He led the team to develop early AI platforms and algorithms (CognitiveEngine/DeepCloud, PrimateAI/DeepFolding/FoldingZero, DeepBipolar/DeepCancer, DeepAtom/DyScore/DrugMetric, MySurgeryRisk, iBond/FLEX,BatmanNet/AptaDiff/RNADiff/AtomicFold). He has published about 200 papers in deep learning, biopharma technology, cloud computing, and security&privacy. His research findings have been applied in drug target discovery, protein folding, RNA/DNA folding, drug design, virtual screening, omics, and clinical decision support systems. Several of his students have become tenured or tenure-track professors in USA (including one in Top Five College of Pharmacy).


    系统递送自复制RNA编码IL-12 (JCXH-211-IV)治疗实体瘤
    RNA World 2024
    Yuanqing Liu
    CSO China, Immorna Biotherapeutics

    Dr. Liu Yuanqing graduated from Shanghai Medical College of Fudan University and was a surgeon at Shanghai Zhongshan Hospital. He completed his PhD in Vrije Universiteit Brussel in Belgium and was one of the pioneers on myeloid-derived suppressors in tumors. He was previously a senior research lead at Sanofi Pasteur French headquarter, where he contributed to various vaccine projects, including cancer vaccines, vaccines against infectious diseases, pediatric vaccines, adjuvants, etc. Dr. Liu is an industry veteran with extensive experience in the development of innovative vaccines for international market. He was a member of the EU Innovative Medicine Initiative. Since 2021, he has been the Chief Scientific Officer of Immorna Biotechnology. He is based in Shanghai where Immorna has established a high-standard R&D site aiming to accelerate the development of mRNA vaccines and drugs in China.

    热稳定型mRNA-LNP产品的制剂开发进展
    RNA World 2024
    Jerry Zhang
    Vice President of Formulation, Abogen Biosciences

    Jerry Zhang joined the Suzhou Abogen Biosciences in May of 2020 and currently serves as the Vice President of Formulation leading the formulation, process development and tech transfer of mRNA-LNP products.

     

    Dr. Zhang has 23 years of experiences in formulation development of sterile parenteral drug products including various complex injectables such as lipid nanoparticles, liposomes, nanoemulsions, polymeric nanoparticles and nanocrystal suspensions as well as lyophilized powders. Prior to joining Abogen, he worked for Hospira (now Pfizer), Daiichi Sankyo and Livzon Pharmaceutical Group as a Senior Research Pharmacist, Supervisor of  Formulation R & D and Senior Director of Formulation, respectively. He also worked on mRNA-LNP formulations at Shire Human Genetic Therapies (now Takeda) and Arcturus Therapeutics to support preclinical studies.

     

    Dr. Zhang holds a PhD in Bioorganic Chemistry from Kyushu University, a MS in Organic Chemistry and a BS in Chemistry from Fudan University. He completed his postdoctoral training at University of Notre Dame and Purdue University in liposome-based systems for triggered release and targeted delivery.


    脂质纳米载体的设计及RNA药物开发的探索
    RNA World 2024
    Xueqing Zhang,
    Professor, Shanghai Jiaotong University, China

    Dr. Xue-Qing Zhang is a Ph.D. advisor at the School of Pharmacy, Shanghai Jiao Tong University. She earned her Ph.D. in Polymer Chemistry and Physics from Wuhan University. In 2010, she joined the research groups of Professor Robert Langer at MIT and Professor Omid Farokhzad at Harvard Medical School in 2010, where she completed the joint postdoctoral training. Following this, she worked for several years in formulation development at a U.S. biopharmaceutical company. Her research focuses on nucleic acid delivery systems and biomedical materials, driven by clinical needs. Specifically, she explores (i) novel mRNA vaccines and their applications in infectious disease prevention, and (ii) targeted nucleic acid nanodelivery systems for treating organ fibrosis, cancer, and cardiovascular diseases, along with the underlying mechanisms. She has published more than 50 SCI papers in journals such as Science Advances, Nature Communications, ACS Nano, and PNAS, with over 8,000 citations. She holds multiple patents, including two granted in the U.S. and eight in China. Her work has gained significant attention and citations both domestically and internationally in the research field of polymer- and lipid-based RNA delivery systems, and has been featured by the Ministry of Science and Technology of China, Polymer Science, ACS Nano, and other media outlets. Dr. Zhang has led several key projects, including the National Biopharmaceutical Technology Innovation Center’s nucleic acid drug development initiative and the "Key Technology Research in Biosafety" project under the National Key R&D Program. She has been recognized by numerous talent programs, including the National High-level Talent Introduction Program for Young Professionals, the Shanghai Pearl Peak Talent, and Program for Innovation and Entrepreneurship Talents in Jiangsu Province. Additionally, she has been invited to serve as a member of the editorial board for the Higher Education Press’s "14th Five-Year Plan" medical textbook Introduction to Pharmacy, the Editorial Board of Drug Regulatory Science and Modern Pharmaceutical Management, and as a technical advisor to the Shanghai Institute of Biological Products.


    单价XBB.1.5 mRNA疫苗的开发
    RNA World 2024
    Andrew Wong
    General Manager, Shanghai Wotai Biotechnology, China

    Andrew Wong is General Manager of Shanghai Wotai Biotechnology Co., Ltd., a subsidiary company of Walvax Biotechnology Co., Ltd., a public listed and leading vaccine development, and manufacturing company in China, where Andrew held a position as Director of Business Development until recently. Andrew had managed Walvax's global business activities including product global registration, sales & marketing, tech-transfer and licensing-in/out for more than 4 years till August 2024.. 

    By participating in Walvax’s efforts to become a global vaccine manufacturer, between September 2015 and March 2020, Andrew managed a three collaboration projects under a combined sum of USD 8.5 million funding from the Bill and Melinda Gates Foundation to support the development of bivalent, nona-valent HPV vaccines and recombinant COVID-19 vaccine for developing countries. Representing Walvax, Andrew participated in the efforts with Shanghai Zerun Biotechnology Co., Ltd, a Walvax subsidiary in Shanghai, to secure grants more than USD 20 millions from CEPI to support the preclinical and clinical development of the variant recombinant COVID-19 vaccine.  Currently, Andrew leads his teams to work on Walvax’s global business expansion through licensing-in/out and international product registration and distribution.

    After academic trainings from China, Canada and United States in clinical medicine, immunology, molecular biology,  and business administration with an MBA from UCLA Anderson School, Andrew Wong, MD, MBA has almost three decades’ experiences in biopharmaceutical research, business development and general management, including close to 12 years’ work experience at the world’s largest biotech company - Amgen Inc. in USA, by engaging in recombinant antibody therapeutics and anticancer small molecule drug research and development.


    合理设计可电离脂质和RNA药物递送
    RNA World 2024
    Xuexiang Han
    Co-founder & CSO , Hanz Biotechnology (Suzhou)

    韩雪祥教授,中科院分子细胞科学卓越创新中心研究员,课题组长,博士生导师。

    入选国家级高层次人才(海外)项目和上海市领军人才(海外)项目。

    汉信生物科技(苏州)有限公司,联合创始人&首席科学家。

    2014年本科毕业于上海大学、2019年博士毕业于清华大学(国家纳米科学中心联合培养);2020-2024年在美国宾夕法尼亚大学Michael J. Mitchell教授实验室从事博士后研究工作,期间与诺奖得主Drew Weissman教授合作开展LNP-mRNA疫苗和药物的研究;2024年2月入职中科院分子细胞科学卓越创新中心。主要研究方向为新型LNP的构建和RNA药物递送,以第一(含共一)作者在Nat. Chem.、Nat. Nanotech.、Nat. Mater.、Nat. Commun.等期刊发表论文近20篇,授权中国专利一项,申请PCT专利多项。


    新加坡mRNA的初生
    RNA World 2024
    Boon Tong Koh
    Executive Director at A*STAR Bioprocessing Technology Institute, Singapore

    Boon Tong joined A*STAR as Executive Director of BTI on 3 May 2021 and was concurrently appointed ED of Nucleic Acid Therapeutic Initiative in October 2023. With over 30 years of experience in the private sector, he had managed specialty chemicals, API operations and businesses in China and India. He comes onboard with deep expertise in managing translational research teams, pharmaceutical operations, and businesses across Asia. He further possesses extensive knowledge in GMP operations encompassing research, pilot, and manufacturing, through prominent roles at GSK and Lonza. Boon Tong graduated with a PhD from the National University of Singapore and is Adjunct Professor at Singapore Institute of Technology (SIT).

    结核病抗原mRNA疫苗的全面筛查在多种动物模型中诱导了强烈的免疫反应
    RNA World 2024
    Wenshuo Zhou
    Leading Scientist & CSO Academic Secretary, CNBG- Virogin Biotech, China

    博士毕业于美国弗吉尼亚州的欧道明大学,主攻方向为Vector-Borne disease中黄热病毒属(LGTV,ZIKV, DENV等病毒)依靠外泌体进行体内体外感染传播的机理研究并将成果发表在多个高影响因子杂志上(PNAS, EMI, PLoS Pathogen等)。

    后在美国食品药品监督管理局FDA,CBER下设的疫苗评审研究办公室OVRR担任白橡树外国科学家项目博士后研究员(ORISE Fellow)从事以减毒风疹病毒为载体对新冠S蛋白,RSV或HIV相关蛋白表达的重组载体疫苗的研发工作。

    目前在国药中生集团旗下的子公司中生复诺健生物科技有限公司担任资深科学家和学术秘书,负责多条传染病mRNA疫苗管线的早期研发和相关学术会议组织和讨论工作。


    基于DNA纳米颗粒平台的SiRNA递送
    RNA World 2024
    Jiajia Zou
    R&D Director, Beijing Intell Nanomedicine

    Jiajia Zou, the Research and Development (R&D) director at Beijing Intell Nanomedicine, earned her doctorate from the University of Glasgow. With seven years of expertise in DNA nanotechnology, she has dedicated three years to advancing the industrialization of DNA nanomaterials, overseeing the development of structural assembly, mass production, and non-clinical projects.

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    VIF World

    Vaccine Innovation Forum World 2025

    第六届疫苗创新国际论坛

    Mar. 20-22

    Shanghai China

    120+ global vaccine leaders speaking

    1000+ international vaccine professionals

    Go to website

    合作伙伴


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    上海兆维科技发展有限公司成立于 1998 年,专业从事核酸原料生产已有 20 多年,产品覆盖核苷及修饰性核苷、核苷酸、亚磷酰胺基因单体、GalNAc 递送分子和生物酶等。公司拥有亚磷酰胺类(基因单体)产品线,年产能 58 吨,核苷三磷酸年产能 5.4 万升(相当于全球 105 亿剂 mRNA 新冠疫苗的原料需求)。公司与世界各地的生物技术和制药公司建立了长期合作关系,现已成为核酸原料领域的优质企业,为众多临床阶段和已商业化的核酸管线供应原料。目前,公司已经建立 mRNA CDMO 和小核酸药物 Oligo CDMO 的服务平台,提供亚磷酰胺单体、GalNAc 等递送分子、从临床前研究到商业化阶段的一站式服务。

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    一家拥有全球领先mRNA技术和mRNA领域全要素研发平台的生物科技公司

    依诺生物是一家拥有全球领先mRNA技术并掌握mRNA领域鲜有的全产业链条自主知识产权技术平台和核心原辅料设备的生物科技公司。 公司打造跨mRNA相关全部学科领域的高水平研究团队,拥有mRNA药物及核心原辅料GMP-like生产线,并构建了可高效并行多项目高度集成化的新药开发流程,可以并行的迭代的快速的满足客户的需求。