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新冠疫情以来,全球疫苗开发正如火如荼。从传统的灭活疫苗,病毒载体疫苗,到新型的mRNA疫苗、DNA疫苗,各种技术路线的疫苗开发相继获得成功。然而奥密克戎变异株的出现让疫苗开发及接种策略变得多元。基于mRNA技术的疫苗开发正在走向多价、联合及新病原疫苗,广谱疫苗也成为新的研发热点,黏膜疫苗以其迅速、及时杀灭病毒的特点正迎来自己的时代。新冠以外,二类疫苗市场的重磅新品迎来持续扩增,PCV13, 带状疱疹疫苗、HPV疫苗等大品种国产疫苗相继上市;辉瑞、GSK的RSV疫苗也传来好消息,给火爆的疫苗市场再度加了一把火。行业正处于飞速发展的黄金期。
此外,新冠疫情的到来,也同时推动了国产疫苗的国际化。中国疫苗已相继进入东南亚、中东、南美、非洲、东欧等一带一路国家沿线。借助新冠疫情的东风,中国疫苗企业已开始深度参与全球疫苗免疫工作,通过广泛的国际合作(包括技术、资源及投资等)把国产高质量疫苗带到世界各地、推动全球健康。
作为国内领先的疫苗产业领域学习、交流盛会,2023疫苗创新国际论坛(VIF)将邀请来自国内外疫苗行业的企业高管、行业领袖、知名学者、政府相关部门等超过400位代表倾情参与并共同探讨当前疫苗行业关注的热点话题,帮助疫苗从业者了解国际疫苗发展前沿、学习最新疫苗知识及行业实践,促进行业交流,从而推动中国疫苗产业的健康发展。
会议议程及会议通知下载:
了解更多会议详情,请联系组委会:
Sam Li 13482341046(微信)
sam.li@chstone-events.com
开幕致辞
Next Generation Nucleic Acid Approaches for Therapeutics/Immune Therapy of Disease and Induction of Protective Immunity
仿生合成疫苗: 从人工颗粒到天然颗粒底盘
疫苗不仅用于预防重大传染病,而且在肿瘤等重大疾病的治疗有着巨大的潜力。因此,理想的疫苗是能同时诱导体液和细胞免疫应答。传统减毒和灭活疫苗可诱导高效体液免疫应答,但存在灭活不彻底或毒力恢复等安全隐患,而且用传统铝佐剂无法提高细胞免疫应答。使用亚单位抗原(病毒样颗粒VLP、蛋白、多肽等)的疫苗安全性明显提升,但却存在着疫苗稳定性差、免疫原性弱、细胞免疫应答低的关键难题。
1)我们提出仿生颗粒的思路,用简单的Pickering乳液模仿病毒、细菌等病原体的特征,作为合成疫苗的“底盘”,与不同的抗原(部件)组装,构建更稳定、高效且能大规模生产的合成疫苗,同时提高了体液免疫和细胞免疫密,且免疫效果远优于普通颗粒。
2)提出利用天然颗粒制备以外泌体为底盘的双靶向肿瘤疫苗的策略,用于肿瘤的个体化精准治疗。从病人肿瘤组织获得个体化肿瘤细胞核,用巨噬细胞吞噬肿瘤细胞核,获得杂化细胞,再用佐剂刺激细胞获得嵌合外泌体,外泌体表面携带肿瘤抗原肽,肿瘤黏附因子等,还携带巨噬细胞的信息。因此,该疫苗通过黏附因子靶向肿瘤组织改善肿瘤微环境,通过巨噬细胞的信息靶向淋巴结激活特异性免疫应答,通过双管齐下作用,获得了优异的肿瘤治疗和预防复发效果。
下一代粘膜疫苗开发
1.Current Vaccine Problem
2.Introducing Inhalation Vaccine
3.Some Highlight Result from Clinical and Real World Study
茶歇交流
mRNA Vaccine Development: COVID and Beyond
后新冠时代RNA疫苗及药物开发
打造全球呼吸系统疾病疫苗的研发体系
Respiratory diseases including low air track infections and related chronical degenerative diseases became leading causes of death globally. Recently, WHO announced the end of the Covid pandemics which lasted over 3 years. SCB-2019 is a protein subunit vaccine with adjuvant against Covid-19. With trials enrolling over 37500 human subjects, SCB-2019 was demonstrated efficacious across various subgroups including adults over 60, adolescence and young adults, either used for primary immunization or as a booster. SCB-2019 can provide protection against pre-omicron and some omicron strains of Covid-19. With EUA of SCB-2019, Clover successfully grew into a full-fledged biopharma with proprietary trimer-tag platform, China-centric discovery and commercial teams, and global development and regulatory capabilities. To meet the need for protection against Covid-19 XBB strains, Clover developed both SCB-2023 including a XBB.1.5 antigen and raced to deliver them before the next wave of pandemics in this year. Along with Covid-19, spread of other respiratory infectious diseases, such as influenza and RSV, also imposed serious threats on human health. Clover in-licensed a Flu vaccine which will hit the market in the 2nd half of this year. Based on trimer-tag and unique stabilizing mutations, RSV vaccine is also under preclinical development with desirable immunogenicity data. Clover is committed to provide comprehensive solutions for vaccination against respiratory diseases.
交流午宴
主持嘉宾
国产首个mRNA新冠疫苗的临床开发
通过创新疫苗研发促进全球健康:Hilleman的经验教训
创新技术赋能mRNA药物研发
解码重组疫苗开发中的佐剂技术应用
茶歇
疫苗定量与免疫原性评价试剂盒研发
机遇及挑战:中国疫苗助力全球健康
亚单位抗原和分子佐剂的纳米递送系统
The vaccines of subunits, peptides, and mRNA represent new generation of vaccination technology for fighting infectious diseases and cancers. However, these biomacromolecules face the problems of degradation, transportation to target tissue and cells, and cellular uptake, which are the obstacles of their technology translation. Delivery technology based on materials and nanoparticular engineering becomes “last mile” of clinical application of novel vaccines. In this talk, I will present our research on nanovaccines by delivering subunits and adjuvants for eliciting potent humoral and cellular response. We have applied both biocompatible materials and engineered fabricating technologies to improve lymph node targeting and retention, and in turn the performance of the novel nanovaccines, which were evaluated in EV71, EBV and HB associated diseases.
鼻内免疫:装置和配方面临的前景与挑战
主持嘉宾
基于可溶性微针递送技术开发DNA疫苗
从寨卡到新冠:疫苗开发与免疫学
应对基于RNA的疫苗开发的知识产权挑战
Dan will provide an in-depth discussion relating to the IP, litigation and competitive landscape in the mRNA and lipid nanoparticle space including recent trends and related analyses.
Novel self-assembled RNA nanoparticles for vaccination and therapy
After the successful development of lipid nanoparticles (LNPs) comprising messenger RNA (mRNA) for vaccination against Covid-19 the interest in mRNA and nanoparticle systems for various therapeutic applications has surged tremendously.
As delivery systems, currently LNPs, which are manufactured by a specific protocol with a defined mixture of four lipids are center of attention. However, there are several other nanoparticle formats which have demonstrated to be promising as delivery systems for RNA and other drugs.
Here some concepts for nanoparticle engineering based on lipids and polymers are presented, which allow for tailoring of the delivers system according to type of (RNA) cargo, application route and the intended therapeutic intervention.
茶歇
开发多价肺炎结合疫苗预防肺炎链球菌引起的疾病
Streptococcus pneumoniae is a leading pathogen commonly colonized in human upper respiratory tract. Pneumococcal infection may cause meningitis, bacteremia, pneumonia, and acute otitis media, especially in susceptible populations. Pneumococcal vaccine has been proved as an effective approach to combat the pneumococcal disease. However, due to emerging of new pneumococcus serotypes and diverse epidemiology across the world, development of more effective vaccines to provide a much wider protection becomes necessary. In this presentation, I will give a summary on the development progress of polyvalent pneumococcal conjugate vaccines worldwide.
俄罗斯疫苗市场、注册及合作机遇
Russia&CIS vaccine markets:dynamics and structure
Overall pharma trends in Russia and development of governmental support
Vaccine market regulatory background
Market entry models and cooperation opportunities
Nanolek as a potential partner
mRNA-DegradaBALL vaccine: the future of non-LNP mRNA vaccine
Lemonex is a pharmaceutical company developing safe and effective RNA therapeutic agents based on innovative non-viral drug delivery system(DDS). The core DDS platform technology,'DegradaBALL, is a novel inorganic nanoparticle-based global first-in-class drug delivery system that maximizes therapeutic efficacy and minimizes systemic side effects.
DegradaBALL minimizes systemic distribution of API through blood vessels and reduces systemic side effects by forming a depot at the injection site. API and DegradaBALL can be filled in different vials and assembled by simple mixing at the point of use before administration. DegradaBALL maintains high stability for more than 2 years at room temperature, making it possible to stock up on inventory through pre-production and to provide the API-DegradaBALL product quickly(i.e. vaccines responding to the next pandemic and new variants).
Recently, Investigational New Drug(IND)application has been submitted to the Ministry of Food and Drug Safety(MFDS)for mRNA-DegradaBALL vaccine, LEM-mR203. LEM-mR203 is a global first-in-class mRNA vaccine employing DegradaBALL drug delivery technology. In the case of LNP, mRNA fragmentation and impurities may occur during the complicated mRNA encapsulation process that must be performed immediately after mRNA synthesis in a dedicated facility. However, DegradaBALL can be pre-produced and stored in stock and can increase mRNA stability. Through DegradaBALL platform technology, Lemonex plan to focus all of core development capabilities on the'Pandemic Vaccine Development within 100 Days'project
Meanwhile, Lemonex is developing various new drug candidates based on the DegradaBALL drug delivery platform. siRNA gene therapy LEM-S401:Completed evaluation of the safety and tolerability of DegradaBALL in human subjects by Phase I clinical trial, Dual-acting RNA immuno-oncology drug LEM-S403:completed the GLP-tox studies including NHP. In addition, Lemonex is strengthening its global network by signing an MOU with the International Vaccine Institute(IVI)and WHO's mRNA vaccine technology
DegradaBALL
Non-LNP, non-viral, extrahepatic mRNA delivery system revolutionizing mRNA Medicine
Highly stable:storage at room temperature(>2 yrs)
Platform DDS technology for the delivery of various APls(siRNA, mRNA, pDNA and Ag protein)
Minimized systemic distribution:reduce systemic side effect
Ready-to-Use system:1)DegradaBALL vial&2)API vial(separate'fill&finish')>'simple mix'at the point of use Pre-mass production and storage possible:to prepare next pandemic situation in advance for'100 days mission'.
交流午宴
主持嘉宾
Convacell – 下一代新冠疫苗开发
基于植物平台的下一代疫苗开发技术
Baiya Phytopharm, company introduction
Baiya pharming process, Plant-based vaccine, and therapeutic protein.
Baiya’s plant-based Covid-19 vaccine development during the pandemic.
Future for Plant-based technology platform.
靶向性LNP在肿瘤疫苗中的应用
Spinraza不为人知的故事
mRNA和LNP研究概述
自研靶向性LNP递送系统
靶向性LNP用于开发mRNA肿瘤疫苗
基于结构的疫苗设计
mRNA创新药物研发的机遇与挑战
小组讨论:疫苗开发的未来
开幕致辞
Dr. Bin Wang is the Co-founder, Chairman of Advaccine Biotechnology Co LTD. He is also holding a distinguished professor position at the Fudan University School of Basic Medical Sciences and serves as the chairman for the Nucleic Acid Vaccines branch of the Chinese Vaccine Society. His research area is focused on the effects of therapeutic vaccination to activate T cells and the mechanism of immune regulations. He has developed novel adjuvants and recombinant vaccines, novel DNA vaccine delivery, and led to several developed vaccines being tested in human clinical trials. He received his Ph.D. from the Cincinnati Children's Hospital at the University of Cincinnati School of Medicine in 1990. He completed his postdoc training in virology and immunology at the Wistar Institute in 1992 in Philadelphia. He became an instructor and assistant professor at the University of Pennsylvania Medical School from 1993 to 1998. He was a professor and served as the Chairman of the Department of Microbiology and Immunology for six years at the College of Biological Sciences, China Agricultural University before he joined Fudan University. He was one of the very early DNA vaccine technology inventors in the 90’s and performed the first-in-human DNA vaccine trials in 1994-1996. He has been involved in several clinical trials of therapeutic vaccines against chronic HBV infections in recent years and invented a novel prophylactic RSV vaccine currently under clinical phase II testing. He has published over 160 peer-review articles and awarded 35 US and 30 Chinese patents. He serves as an editorial board member for several international journals and executive member in several professional societies.
Next Generation Nucleic Acid Approaches for Therapeutics/Immune Therapy of Disease and Induction of Protective Immunity
Dr. David Weiner directs a translational research laboratory at The Wistar Institute in the area of Molecular Immunology. His group is one of the pioneering research teams in establishing the field of DNA vaccines and immunotherapies. Important reports from his lab include the first DNA vaccine studied for HIV as well as for cancer immunotherapy, the early development of DNA encoded genetic adjuvants including the particularly relevant IL-12, advances in gene optimization, and advances in electroporation (EP) technologies resulting in improved gene delivery among others. His group worked with collaborators to become the first to move DNA technology into human study. His laboratory’s work helped revitalize the field through advancement of new synthetic DNA design and modification of EP delivery approaches resulting in potent immune induction as well as the first successful Phase IIb DNA efficacy study (for HPV immunotherapy) in humans. Dr. Weiner is the recipient of numerous honors including election as a fellow to both the American Association for the Advancement of Science in 2011 and the International Society for Vaccines in 2012. He is the recipient of the NIH Director’s Transformative Research Award and received the Vaccine Industry Excellence Award for Best Academic Research Team in 2015 at the World Vaccine Congress. Weiner was honored with the prestigious Hilleman Lectureship in 2015 at the Children’s Hospital of Philadelphia Grand Rounds session and received a Stone Family Award from Abramson Cancer Center for his groundbreaking work on DNA vaccines for cancer immunotherapy. In 2019, Dr. Weiner was honored with the Scientific Achievement Award from Life Sciences PA (LSPA). Dr. Weiner returned to Wistar in 2016 from his position at The University of Pennsylvania School of Medicine as professor of Pathology and Laboratory Medicine. From 1990 to 1993, Weiner held a joint position as assistant professor of Pathology and Laboratory Medicine at The Wistar Institute and the University of Pennsylvania School of Medicine. Dr. Weiner is a co-founder of Inovio Pharmaceuticals and is a member of the Board of Directors. Dr. Weiner graduated with a B.S. in biology from SUNY at Stony Brook, N.Y., a M.S. in biology from the University of Cincinnati and a Ph.D. in developmental biology from the University of Cincinnati College of Medicine.
仿生合成疫苗: 从人工颗粒到天然颗粒底盘
下一代粘膜疫苗开发
茶歇交流
mRNA Vaccine Development: COVID and Beyond
后新冠时代RNA疫苗及药物开发
Dr. Liu Yuanqing graduated from Shanghai Medical College of Fudan University and was a surgeon at Shanghai Zhongshan Hospital. He completed his PhD in Vrije Universiteit Brussel in Belgium and was one of the pioneers on myeloid-derived suppressors in tumors. He was previously a senior research lead at Sanofi Pasteur French headquarter, where he contributed to various vaccine projects, including cancer vaccines, vaccines against infectious diseases, pediatric vaccines, adjuvants, etc. Dr. Liu is an industry veteran with extensive experience in the development of innovative vaccines for international market. He was a member of the EU Innovative Medicine Initiative. Since 2021, he has been the Chief Scientific Officer of Immorna Biotechnology. He is based in Shanghai where Immorna has established a high-standard R&D site aiming to accelerate the development of mRNA vaccines and drugs in China.
打造全球呼吸系统疾病疫苗的研发体系
Dr. Tan is responsible for drug discovery, preclinical development, translation research and external collaboration in China. Dr. Tan got his Ph.D. in Molecular Medicine from UT Health Science Center San Antonio and received his Postdoctoral training with Dr. Michael Karin at UC San Diego. Dr. Tan worked in Pfizer and Novartis for 9 years, specialized in drug discovery and translational research, bridging preclinical research to early clinical trials. Dr. Tan worked at Biosion Biotech and Coherent Biopharma before he joined Clover. Dr. Tan was selected as Jiangsu Innovation and Entrepreneur Talent and Suzhou Innovation and Entrepreneur Leading Talent.
交流午宴
主持嘉宾
Dexiang Chen, Doctor of Immunology, Mississippi State University, has been engaged in the development of vaccines and vaccine adjuvants in Pfizer, Novartis and PATH scientific and technological organizations for more than 30 years, and has presided over a number of major international public health special projects funded by international organizations, foundations and national governments. Among the more than 20 infectious disease vaccine development projects presided over and participated in, many products have been listed globally. Dr. Chen Dexiang has published more than 60 vaccine-related academic papers in world-class academic journals such as Science and Nature Medicine.
国产首个mRNA新冠疫苗的临床开发
通过创新疫苗研发促进全球健康:Hilleman的经验教训
创新技术赋能mRNA药物研发
解码重组疫苗开发中的佐剂技术应用
Dexiang Chen, Doctor of Immunology, Mississippi State University, has been engaged in the development of vaccines and vaccine adjuvants in Pfizer, Novartis and PATH scientific and technological organizations for more than 30 years, and has presided over a number of major international public health special projects funded by international organizations, foundations and national governments. Among the more than 20 infectious disease vaccine development projects presided over and participated in, many products have been listed globally. Dr. Chen Dexiang has published more than 60 vaccine-related academic papers in world-class academic journals such as Science and Nature Medicine.
茶歇
疫苗定量与免疫原性评价试剂盒研发
Beijing special expert, Beijing COVID-19 prevention and technology talent, Beijing Normal University adjunct professor, Tsinghua University doctor, Oregon State University postdoctoral. Dr. Sun Le studied under Professor G. Sato, a member of the American Academy of Sciences, scientific Advisor to President Nixon, inventor of monoclonal antibody drugs, and Professor Zhao Nanming, former Dean of the School of Life Sciences and Medicine of Tsinghua University. Formerly Director of production and scientific research at Upstate/Merck USA; Founded A&G Pharmaceuticals in the United States in 2000 and served as President. Having undertaken a number of major national and Beijing science and technology projects, Jingtiancheng, as a key enterprise in Beijing's infectious disease emergency prevention and control platform, has played an important role in the fight against rabies, hand-foot-mouth EV71, avian influenza H1N1/H7N9, new Pornia virus, Norovirus, Ebola virus and novel coronavirus. Established a huge library of infectious disease pathogens antibodies, including pneumonia 18, HPV9, meningitis 4, DPT, rabies, Bunya Virus, EV71, CA16, HBV, HCV, HEV, HIV, IPV, rubella virus, RSV, RAV,JEV mouse mab thousands of species. In this outbreak, Dr. Sun Le was supported by the Major COVID-19 Emergency Project of the Beijing Municipal Science and Technology Commission and the Gates Foundation COVID-19 Emergency Project respectively.
机遇及挑战:中国疫苗助力全球健康
亚单位抗原和分子佐剂的纳米递送系统
Yongming Chen received his Ph.D. on polymer science in 1993 from Nankai University. From 1994 to 1998, he was Postdoctoral Researcher and later Research Assistant at the Institute of Chemistry, CAS. Then he spent the period 1998−2001 as Postdoctoral Researcher in University of Düsseldorf and University of Mainz. Since 2001, Chen was Professor at the Institute of Chemistry CAS. He moved to Sun Yat-sen University in 2013. He obtained “Distinguished Young Scholars” by National Science Foundation of China (2006). He served for Polymer, an Elsevier journal, as an Associate Editor during 2007 to 2018. He also was in Advisory Board Panel of Macromolecules and ACS Macro Letters, the ACS Publication. Professor Chen’s research interests are in the areas of biomaterials chemistry and biomaterials application in delivery of proteins and nucleic acids, specifically application in immune attenuation. He has published over 260 research articles in Science Advances, Nature Communication, Biomaterials, Nano Letters et al and obtained 10 more licenced patents.
鼻内免疫:装置和配方面临的前景与挑战
Dr. Julie D. Suman is the Vice President of Scientific Affairs for Aptar Pharma. She manages strategic scientific planning and Aptar’s Scientific Advisory Board. Dr. Suman is also the co-founder of Next Breath. She holds a B.S. in Pharmacy from Duquesne University (1996) and a Ph.D. in Pharmaceutical Sciences from the University of Maryland, Baltimore (2002). Dr. Suman serves on the External Advisory Committee of the New South Wales RNA Production and Research Network. In addition, she is a co-editor for Respiratory Drug Delivery Proceedings, an international symposium, and an an Affiliate Assistant Professor in the Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University. Dr. Suman is the Past-Chair of the AAPS Inhalation Technology Focus Group. Dr. Suman is also a member of the Parental Drug Association Visible Particulate Taskforce. She is a licensed Maryland pharmacist. Dr. Suman has published her research in peer-reviewed journals and has been presented during podium sessions at international meetings, the FDA Topics in Bioequivalence Seminar Series and has been an invited speaker at ANVISA in Brazil. Dr. Suman’s doctoral research, which focused on the relationship between in vitro tests for nasal sprays and in vivo deposition, has been recognized for excellence by a research award presented at the International Society for Aerosols in Medicine, 2001. In 2008, Dr. Suman received an award from the Greater Baltimore Committee for Entrepreneurial Spirit.
Nektaria Karavas is the Global Director of Business Development for Nasal Vaccines, Antivirals and Immuno-stimulants at Aptar Pharma. Ms. Karavas joined Aptar Pharma in 2004 and has held various commercial roles executing long-term strategy within key customer and global accounts in North America focusing on nasal drug delivery. She has contributed to multiple nasal development programs, supported commercial scale up and product launches for New Drug Applications (NDA) using an Aptar delivery device for key pharmaceutical clients across different therapeutic indications. Nektaria holds a Bachelor of Science from McGill University, Montreal, Canada
主持嘉宾
Dr. Jeff Zhu is the founder and CEO of Shanghai Reinovax Biologics co., Ltd., a fast-growing biotech company focusing on discovery and development of innovative vaccines and other biologics. Dr. Zhu has over 20 years’ industrial experience on discovery and development of small molecules, recombinant proteins, antibodies and vaccines from the early discovery to clinical trials. He played an important role in moving multiple drug candidates from the initiation to the clinical trial stage during his 13-year tenure at Pfizer’s R & D center in San Diego. Dr. Zhu moved back to China in 2011, and served as CSO and head of the R & D at Hualan Biological Engineering Inc., and two years later worked as senior director and department head in USP, Shanghai. Dr. Zhu published earned his Ph.D. degree on biological sciences from UC, Irvine, M.S. degree on biochemistry from Georgetown university, and B.S. degree on chemistry from Tsinghua university.
基于可溶性微针递送技术开发DNA疫苗
Dr. Bin Wang is the Co-founder, Chairman of Advaccine Biotechnology Co LTD. He is also holding a distinguished professor position at the Fudan University School of Basic Medical Sciences and serves as the chairman for the Nucleic Acid Vaccines branch of the Chinese Vaccine Society. His research area is focused on the effects of therapeutic vaccination to activate T cells and the mechanism of immune regulations. He has developed novel adjuvants and recombinant vaccines, novel DNA vaccine delivery, and led to several developed vaccines being tested in human clinical trials. He received his Ph.D. from the Cincinnati Children's Hospital at the University of Cincinnati School of Medicine in 1990. He completed his postdoc training in virology and immunology at the Wistar Institute in 1992 in Philadelphia. He became an instructor and assistant professor at the University of Pennsylvania Medical School from 1993 to 1998. He was a professor and served as the Chairman of the Department of Microbiology and Immunology for six years at the College of Biological Sciences, China Agricultural University before he joined Fudan University. He was one of the very early DNA vaccine technology inventors in the 90’s and performed the first-in-human DNA vaccine trials in 1994-1996. He has been involved in several clinical trials of therapeutic vaccines against chronic HBV infections in recent years and invented a novel prophylactic RSV vaccine currently under clinical phase II testing. He has published over 160 peer-review articles and awarded 35 US and 30 Chinese patents. He serves as an editorial board member for several international journals and executive member in several professional societies.
从寨卡到新冠:疫苗开发与免疫学
应对基于RNA的疫苗开发的知识产权挑战
Novel self-assembled RNA nanoparticles for vaccination and therapy
Heinrich Haas, Department of Biopharmaceutics and Pharmaceutical Technology Johannes Gutenberg-Universität, Mainz Mainz, Germany. Ph.D. in the group of Prof. Dr. Helmuth Möhwald at Johannes-Gutenberg Universität Mainz. Researched lipid membranes and organized bio-molecular systems. In pharmaceutical industry (Munich Biotech, Medigene, BioNTech) developed different types of nanoparticle products to clinical stage. Focus on advanced approaches for nanoparticle development and control.
茶歇
开发多价肺炎结合疫苗预防肺炎链球菌引起的疾病
Dr. Jeff Zhu is the founder and CEO of Shanghai Reinovax Biologics co., Ltd., a fast-growing biotech company focusing on discovery and development of innovative vaccines and other biologics. Dr. Zhu has over 20 years’ industrial experience on discovery and development of small molecules, recombinant proteins, antibodies and vaccines from the early discovery to clinical trials. He played an important role in moving multiple drug candidates from the initiation to the clinical trial stage during his 13-year tenure at Pfizer’s R & D center in San Diego. Dr. Zhu moved back to China in 2011, and served as CSO and head of the R & D at Hualan Biological Engineering Inc., and two years later worked as senior director and department head in USP, Shanghai. Dr. Zhu published earned his Ph.D. degree on biological sciences from UC, Irvine, M.S. degree on biochemistry from Georgetown university, and B.S. degree on chemistry from Tsinghua university.
俄罗斯疫苗市场、注册及合作机遇
mRNA-DegradaBALL vaccine: the future of non-LNP mRNA vaccine
交流午宴
主持嘉宾
Convacell – 下一代新冠疫苗开发
基于植物平台的下一代疫苗开发技术
靶向性LNP在肿瘤疫苗中的应用
基于结构的疫苗设计
Shaowei Li Ph.D. Professor of Biochemistry and Structural Vaccinology, Xiamen University Shaowei Li is a tenured Professor of Biochemistry and Structural Vaccinology in the School of Life Sciences with a joint appointment in the School of Public Health, Xiamen University, China. He is the vaccine group leader in the National Institute of Diagnostics and Vaccine Development in infectious diseases (NIDVD), one of the academic leaders in the State Key Laboratory of Molecular Vaccinology and Diagnostics, deputy director in Fujian provincial Xiang An biomedicine laboratory. Dr. Li has inter-disciplinary research interests focusing on structural vaccinology, resulting in more than 120 peer-reviewed papers. He also has translational experience in vaccine development against infectious diseases—such as Hepatitis E vaccine and HPV vaccine, especially in aspects of immunogen design, process development and antigen characterization. Dr. Li has won two of China’s National Science and Technology Awards and been listed in the Top 20 translational researchers of 2016, ranked by Nature Biotechnology. He has served on the Product Development for Vaccines Advisory Committee (PDVAC), World Health Organization (WHO) since 2022.
mRNA创新药物研发的机遇与挑战
Xiangrong Song is a full professor at Sichuan University and a pharmaceutical scientist at National Key Laboratory of Biotherapy. The Song lab has developed the targeted delivery systems for gene drugs and small molecules to treat tumors, atherosclerosis, ocular diseases, infection or brain diseases. Two novel drug candidates (IND) have been approved for phase I clinical trials. She has authored more than 100 papers and is an inventor of more than 50 issued / pending patents worldwide. The technologies that Dr. Song and her colleagues have developed formed the basis for the launch of 2 biotechnology companies. The two companies are translating the aforementioned academic innovations toward commercialization and societal impact. In 2019, she was a recipient of the first prize of Science and Technology Award in Chinese National Medicine Association, for the research on immune function of Yi nationality's medicine. In 2022, she was named as the elite of science and technology in China.
小组讨论:疫苗开发的未来
Shaowei Li Ph.D. Professor of Biochemistry and Structural Vaccinology, Xiamen University Shaowei Li is a tenured Professor of Biochemistry and Structural Vaccinology in the School of Life Sciences with a joint appointment in the School of Public Health, Xiamen University, China. He is the vaccine group leader in the National Institute of Diagnostics and Vaccine Development in infectious diseases (NIDVD), one of the academic leaders in the State Key Laboratory of Molecular Vaccinology and Diagnostics, deputy director in Fujian provincial Xiang An biomedicine laboratory. Dr. Li has inter-disciplinary research interests focusing on structural vaccinology, resulting in more than 120 peer-reviewed papers. He also has translational experience in vaccine development against infectious diseases—such as Hepatitis E vaccine and HPV vaccine, especially in aspects of immunogen design, process development and antigen characterization. Dr. Li has won two of China’s National Science and Technology Awards and been listed in the Top 20 translational researchers of 2016, ranked by Nature Biotechnology. He has served on the Product Development for Vaccines Advisory Committee (PDVAC), World Health Organization (WHO) since 2022.
Xiangrong Song is a full professor at Sichuan University and a pharmaceutical scientist at National Key Laboratory of Biotherapy. The Song lab has developed the targeted delivery systems for gene drugs and small molecules to treat tumors, atherosclerosis, ocular diseases, infection or brain diseases. Two novel drug candidates (IND) have been approved for phase I clinical trials. She has authored more than 100 papers and is an inventor of more than 50 issued / pending patents worldwide. The technologies that Dr. Song and her colleagues have developed formed the basis for the launch of 2 biotechnology companies. The two companies are translating the aforementioned academic innovations toward commercialization and societal impact. In 2019, she was a recipient of the first prize of Science and Technology Award in Chinese National Medicine Association, for the research on immune function of Yi nationality's medicine. In 2022, she was named as the elite of science and technology in China.
Dr. David Weiner directs a translational research laboratory at The Wistar Institute in the area of Molecular Immunology. His group is one of the pioneering research teams in establishing the field of DNA vaccines and immunotherapies. Important reports from his lab include the first DNA vaccine studied for HIV as well as for cancer immunotherapy, the early development of DNA encoded genetic adjuvants including the particularly relevant IL-12, advances in gene optimization, and advances in electroporation (EP) technologies resulting in improved gene delivery among others. His group worked with collaborators to become the first to move DNA technology into human study. His laboratory’s work helped revitalize the field through advancement of new synthetic DNA design and modification of EP delivery approaches resulting in potent immune induction as well as the first successful Phase IIb DNA efficacy study (for HPV immunotherapy) in humans. Dr. Weiner is the recipient of numerous honors including election as a fellow to both the American Association for the Advancement of Science in 2011 and the International Society for Vaccines in 2012. He is the recipient of the NIH Director’s Transformative Research Award and received the Vaccine Industry Excellence Award for Best Academic Research Team in 2015 at the World Vaccine Congress. Weiner was honored with the prestigious Hilleman Lectureship in 2015 at the Children’s Hospital of Philadelphia Grand Rounds session and received a Stone Family Award from Abramson Cancer Center for his groundbreaking work on DNA vaccines for cancer immunotherapy. In 2019, Dr. Weiner was honored with the Scientific Achievement Award from Life Sciences PA (LSPA). Dr. Weiner returned to Wistar in 2016 from his position at The University of Pennsylvania School of Medicine as professor of Pathology and Laboratory Medicine. From 1990 to 1993, Weiner held a joint position as assistant professor of Pathology and Laboratory Medicine at The Wistar Institute and the University of Pennsylvania School of Medicine. Dr. Weiner is a co-founder of Inovio Pharmaceuticals and is a member of the Board of Directors. Dr. Weiner graduated with a B.S. in biology from SUNY at Stony Brook, N.Y., a M.S. in biology from the University of Cincinnati and a Ph.D. in developmental biology from the University of Cincinnati College of Medicine.
Heinrich Haas, Department of Biopharmaceutics and Pharmaceutical Technology Johannes Gutenberg-Universität, Mainz Mainz, Germany. Ph.D. in the group of Prof. Dr. Helmuth Möhwald at Johannes-Gutenberg Universität Mainz. Researched lipid membranes and organized bio-molecular systems. In pharmaceutical industry (Munich Biotech, Medigene, BioNTech) developed different types of nanoparticle products to clinical stage. Focus on advanced approaches for nanoparticle development and control.
Dr. Bin Wang is the Co-founder, Chairman of Advaccine Biotechnology Co LTD. He is also holding a distinguished professor position at the Fudan University School of Basic Medical Sciences and serves as the chairman for the Nucleic Acid Vaccines branch of the Chinese Vaccine Society. His research area is focused on the effects of therapeutic vaccination to activate T cells and the mechanism of immune regulations. He has developed novel adjuvants and recombinant vaccines, novel DNA vaccine delivery, and led to several developed vaccines being tested in human clinical trials. He received his Ph.D. from the Cincinnati Children's Hospital at the University of Cincinnati School of Medicine in 1990. He completed his postdoc training in virology and immunology at the Wistar Institute in 1992 in Philadelphia. He became an instructor and assistant professor at the University of Pennsylvania Medical School from 1993 to 1998. He was a professor and served as the Chairman of the Department of Microbiology and Immunology for six years at the College of Biological Sciences, China Agricultural University before he joined Fudan University. He was one of the very early DNA vaccine technology inventors in the 90’s and performed the first-in-human DNA vaccine trials in 1994-1996. He has been involved in several clinical trials of therapeutic vaccines against chronic HBV infections in recent years and invented a novel prophylactic RSV vaccine currently under clinical phase II testing. He has published over 160 peer-review articles and awarded 35 US and 30 Chinese patents. He serves as an editorial board member for several international journals and executive member in several professional societies.
Shaowei Li Ph.D. Professor of Biochemistry and Structural Vaccinology, Xiamen University Shaowei Li is a tenured Professor of Biochemistry and Structural Vaccinology in the School of Life Sciences with a joint appointment in the School of Public Health, Xiamen University, China. He is the vaccine group leader in the National Institute of Diagnostics and Vaccine Development in infectious diseases (NIDVD), one of the academic leaders in the State Key Laboratory of Molecular Vaccinology and Diagnostics, deputy director in Fujian provincial Xiang An biomedicine laboratory. Dr. Li has inter-disciplinary research interests focusing on structural vaccinology, resulting in more than 120 peer-reviewed papers. He also has translational experience in vaccine development against infectious diseases—such as Hepatitis E vaccine and HPV vaccine, especially in aspects of immunogen design, process development and antigen characterization. Dr. Li has won two of China’s National Science and Technology Awards and been listed in the Top 20 translational researchers of 2016, ranked by Nature Biotechnology. He has served on the Product Development for Vaccines Advisory Committee (PDVAC), World Health Organization (WHO) since 2022.
Dexiang Chen, Doctor of Immunology, Mississippi State University, has been engaged in the development of vaccines and vaccine adjuvants in Pfizer, Novartis and PATH scientific and technological organizations for more than 30 years, and has presided over a number of major international public health special projects funded by international organizations, foundations and national governments. Among the more than 20 infectious disease vaccine development projects presided over and participated in, many products have been listed globally. Dr. Chen Dexiang has published more than 60 vaccine-related academic papers in world-class academic journals such as Science and Nature Medicine.
Xiangrong Song is a full professor at Sichuan University and a pharmaceutical scientist at National Key Laboratory of Biotherapy. The Song lab has developed the targeted delivery systems for gene drugs and small molecules to treat tumors, atherosclerosis, ocular diseases, infection or brain diseases. Two novel drug candidates (IND) have been approved for phase I clinical trials. She has authored more than 100 papers and is an inventor of more than 50 issued / pending patents worldwide. The technologies that Dr. Song and her colleagues have developed formed the basis for the launch of 2 biotechnology companies. The two companies are translating the aforementioned academic innovations toward commercialization and societal impact. In 2019, she was a recipient of the first prize of Science and Technology Award in Chinese National Medicine Association, for the research on immune function of Yi nationality's medicine. In 2022, she was named as the elite of science and technology in China.
Yongming Chen received his Ph.D. on polymer science in 1993 from Nankai University. From 1994 to 1998, he was Postdoctoral Researcher and later Research Assistant at the Institute of Chemistry, CAS. Then he spent the period 1998−2001 as Postdoctoral Researcher in University of Düsseldorf and University of Mainz. Since 2001, Chen was Professor at the Institute of Chemistry CAS. He moved to Sun Yat-sen University in 2013. He obtained “Distinguished Young Scholars” by National Science Foundation of China (2006). He served for Polymer, an Elsevier journal, as an Associate Editor during 2007 to 2018. He also was in Advisory Board Panel of Macromolecules and ACS Macro Letters, the ACS Publication. Professor Chen’s research interests are in the areas of biomaterials chemistry and biomaterials application in delivery of proteins and nucleic acids, specifically application in immune attenuation. He has published over 260 research articles in Science Advances, Nature Communication, Biomaterials, Nano Letters et al and obtained 10 more licenced patents.
Dr. Liu Yuanqing graduated from Shanghai Medical College of Fudan University and was a surgeon at Shanghai Zhongshan Hospital. He completed his PhD in Vrije Universiteit Brussel in Belgium and was one of the pioneers on myeloid-derived suppressors in tumors. He was previously a senior research lead at Sanofi Pasteur French headquarter, where he contributed to various vaccine projects, including cancer vaccines, vaccines against infectious diseases, pediatric vaccines, adjuvants, etc. Dr. Liu is an industry veteran with extensive experience in the development of innovative vaccines for international market. He was a member of the EU Innovative Medicine Initiative. Since 2021, he has been the Chief Scientific Officer of Immorna Biotechnology. He is based in Shanghai where Immorna has established a high-standard R&D site aiming to accelerate the development of mRNA vaccines and drugs in China.
Dr. Jeff Zhu is the founder and CEO of Shanghai Reinovax Biologics co., Ltd., a fast-growing biotech company focusing on discovery and development of innovative vaccines and other biologics. Dr. Zhu has over 20 years’ industrial experience on discovery and development of small molecules, recombinant proteins, antibodies and vaccines from the early discovery to clinical trials. He played an important role in moving multiple drug candidates from the initiation to the clinical trial stage during his 13-year tenure at Pfizer’s R & D center in San Diego. Dr. Zhu moved back to China in 2011, and served as CSO and head of the R & D at Hualan Biological Engineering Inc., and two years later worked as senior director and department head in USP, Shanghai. Dr. Zhu published earned his Ph.D. degree on biological sciences from UC, Irvine, M.S. degree on biochemistry from Georgetown university, and B.S. degree on chemistry from Tsinghua university.
Nektaria Karavas is the Global Director of Business Development for Nasal Vaccines, Antivirals and Immuno-stimulants at Aptar Pharma. Ms. Karavas joined Aptar Pharma in 2004 and has held various commercial roles executing long-term strategy within key customer and global accounts in North America focusing on nasal drug delivery. She has contributed to multiple nasal development programs, supported commercial scale up and product launches for New Drug Applications (NDA) using an Aptar delivery device for key pharmaceutical clients across different therapeutic indications. Nektaria holds a Bachelor of Science from McGill University, Montreal, Canada
Dr. Julie D. Suman is the Vice President of Scientific Affairs for Aptar Pharma. She manages strategic scientific planning and Aptar’s Scientific Advisory Board. Dr. Suman is also the co-founder of Next Breath. She holds a B.S. in Pharmacy from Duquesne University (1996) and a Ph.D. in Pharmaceutical Sciences from the University of Maryland, Baltimore (2002). Dr. Suman serves on the External Advisory Committee of the New South Wales RNA Production and Research Network. In addition, she is a co-editor for Respiratory Drug Delivery Proceedings, an international symposium, and an an Affiliate Assistant Professor in the Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University. Dr. Suman is the Past-Chair of the AAPS Inhalation Technology Focus Group. Dr. Suman is also a member of the Parental Drug Association Visible Particulate Taskforce. She is a licensed Maryland pharmacist. Dr. Suman has published her research in peer-reviewed journals and has been presented during podium sessions at international meetings, the FDA Topics in Bioequivalence Seminar Series and has been an invited speaker at ANVISA in Brazil. Dr. Suman’s doctoral research, which focused on the relationship between in vitro tests for nasal sprays and in vivo deposition, has been recognized for excellence by a research award presented at the International Society for Aerosols in Medicine, 2001. In 2008, Dr. Suman received an award from the Greater Baltimore Committee for Entrepreneurial Spirit.
Beijing special expert, Beijing COVID-19 prevention and technology talent, Beijing Normal University adjunct professor, Tsinghua University doctor, Oregon State University postdoctoral. Dr. Sun Le studied under Professor G. Sato, a member of the American Academy of Sciences, scientific Advisor to President Nixon, inventor of monoclonal antibody drugs, and Professor Zhao Nanming, former Dean of the School of Life Sciences and Medicine of Tsinghua University. Formerly Director of production and scientific research at Upstate/Merck USA; Founded A&G Pharmaceuticals in the United States in 2000 and served as President. Having undertaken a number of major national and Beijing science and technology projects, Jingtiancheng, as a key enterprise in Beijing's infectious disease emergency prevention and control platform, has played an important role in the fight against rabies, hand-foot-mouth EV71, avian influenza H1N1/H7N9, new Pornia virus, Norovirus, Ebola virus and novel coronavirus. Established a huge library of infectious disease pathogens antibodies, including pneumonia 18, HPV9, meningitis 4, DPT, rabies, Bunya Virus, EV71, CA16, HBV, HCV, HEV, HIV, IPV, rubella virus, RSV, RAV,JEV mouse mab thousands of species. In this outbreak, Dr. Sun Le was supported by the Major COVID-19 Emergency Project of the Beijing Municipal Science and Technology Commission and the Gates Foundation COVID-19 Emergency Project respectively.
Dr. Tan is responsible for drug discovery, preclinical development, translation research and external collaboration in China. Dr. Tan got his Ph.D. in Molecular Medicine from UT Health Science Center San Antonio and received his Postdoctoral training with Dr. Michael Karin at UC San Diego. Dr. Tan worked in Pfizer and Novartis for 9 years, specialized in drug discovery and translational research, bridging preclinical research to early clinical trials. Dr. Tan worked at Biosion Biotech and Coherent Biopharma before he joined Clover. Dr. Tan was selected as Jiangsu Innovation and Entrepreneur Talent and Suzhou Innovation and Entrepreneur Leading Talent.
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