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第六届疫苗创新国际论坛是一个致力于推进疫苗科学和全球健康的顶级国际盛会。在之前论坛的巨大成功基础上,今年的会议旨在进一步巩固其作为专家、研究人员、政策制定者和行业领导者的重要交流平台的声誉;从全球视角,推动免疫、疫苗、全球健康等领域的产、学、研、政府及非政府组织间的国际创新及合作。
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欢迎参加 VIF World 2025 的独家一对一合作会议。在这里,疫苗和生物制药领域的领军人物和创新者将进行深入交流。这是一个难得的机会,让参会者寻找潜在的合作伙伴,并探索潜在的合作机会。不要错过与行业专家建立联系的良机,提升您对未来疫苗开发的理解。在线系统将在活动日期前一个月开放,敬请关注!
The current COVID-19 failed in protection of infection by SARS-CoV-2 variants. It is clear that we need a much better vaccine(s) which has a broad-spectrum protection against the current circulating variants as well as further related viruses. Learning from the broad immunity observed in SARS survivors who subsequently received COVID-19 vaccine and/or got infected with SARS-CoV-2, we have adopted a cross-clade boosting strategy to develop pan-sarbeCoV vaccines which have demonstrated broad neutralization ability against all current variants as well as sarbeCoVs in clade-1a and clade-2 and -3.
Influenza epidemics and pandemics caused by newly emerging virus strains highlight an urgent need to develop a universal vaccine against viruses. Previously, a monoglycosylated X-181mg vaccine demonstrated that the HA possessing a single N-acetylglucosamine at each N-glycosylation site is superior to confer broader protection in mice than conventional vaccines. However, the greatest challenge in conducting clinical trials is the need to develop robust manufacturing processes capable of producing vaccines at the pilot scale with the desired stability, potency, and efficacy. Whether the monoglycosylated virus vaccine platform can be applied to the new vaccine strain in a timely manner and whether the mass-produced vaccine has the proper immunogenicity to induce cross-protective immunity remains unclear. Here, we show that a pilot-scale manufacturing process produced a monoglycosylated A/Brisbane/02/2018(H1N1) virus vaccine (IVR-190mg) with a single glycan at each glycosylation site of HA and NA. Compared with the fully glycosylated virus vaccine (IVR-190fg), the IVR- 190mg provided broader cross-protection in mice against a wide range of H1N1 variants. The enhanced antibody responses induced by IVR-190mg immunization include higher hemagglutination-inhibition titers, higher neutralization activity, more anti-HA head domain, more anti-HA stem antibodies, higher neuraminidase activity inhibition titers, and notably, higher antibody-dependent cellular cytotoxicity. Additionally, the IVR-190mg also induced a more balanced Th1/Th2 response and elicited broader splenic CD4+ and CD8+ T-cell responses than IVR-190fg. This study demonstrated that IVR-190mg produced using a pilot-scale manufacturing process elicits comprehensive cross-strain immune responses that have great potential to substantially mitigate the need for yearly reformulation of strain-specific inactivated vaccines.
1. Clinical Data – Presenting groundbreaking progress in liver cancer treatment, including clinical trial data from the WGc-0201 project, demonstrating its safety, efficacy, and immunogenicity.
2. Platform Technology Highlights – Showcasing WestGene’s proprietary delivery systems and mRNA sequence design, backed by independent intellectual property.
3. Breakthrough Potential – Highlighting the disruptive potential of mRNA technology in tumor immunotherapy.
Tuberculosis (TB) remains one of the world’s leading causes of death from a single infectious agent, Mycobacterium tuberculosis (Mtb). Despite the wide administration of the Bacille Calmette Guerin (BCG) vaccine, which offers variable, age-dependent protection, the need for a new vaccine effective across all age groups and for population with latent tuberculosis infection (LTBI) is essential for achieving the WHO's End TB Strategy. Recent data suggested that future vaccine designs should prioritize on eliciting lung-localized adaptive immune responses. Promising clinical results from CanSinoBIO’s first-generation TB vaccine, Ad5-Ag85A, highlight the crucial role of mucosal immunity in defending against TB. Currently, CanSinoBIO is in a quick process of the development of the new generation TB vaccine, ADTB, designed as an inhalation booster for individuals immunized with BCG, aiming to prevent new TB infections and the reactivation of LTBI. Utilizing a well-established adenovirus vector, ADTB carries three fused antigens and will be delivered via inhalation, a route successfully employed for CanSinoBIO’s Convidecia AirTM, the world's first inhaled COVID-19 vaccine. Extensive data from clinical trials and post-commercialization studies have proved the safety and efficacy of inhaled Ad5-vectored COVID-19 vaccines. The immunogenicity study of new generation TB vaccine in animal model demonstrated that the lower dose of ADTB can stimulated more robust cellular immune responses locally in the lungs, as well as systemically in the blood and spleen. The protection efficacy results indicated that ADTB effectively inhibits Mtb growth in the lungs and prevents lung damage. Overall, the promising preclinical data encourage further clinical trials of the ADTB vaccine.
The nose is far more than just a passive tube to get air to the lungs. It serves as a sophisticated and dynamic immune barrier. In this regard, the nose is a critical component of the body's immune defense system, equipped with multiple mechanisms to detect, regulate, and respond to potential threats, thereby playing a vital role in maintaining respiratory health. The nose knows why and how.
Current intramuscular (IM) COVID-19 vaccines inadequately protect the upper respiratory mucosa. In response, we have developed a nonadjuvanted, interferon-armed SARS-CoV-2 fusion protein vaccine with IM priming and intranasal (IN) boost sequential immunization. Our study shows that this sequential vaccination strategy of the IM+IN significantly enhances both upper respiratory and systemic antiviral immunity in a mouse model, marked by rapid enhancement in systemic and mucosal T and B cell responses, particularly the mucosal IgA antibody response. The IN boost triggers a swift secondary immune response, rapidly inducing antigen-specific IgA+ B cells. Further BCR-seq analysis indicates that these IgA+ B cells primarily arise through direct class switching from pre-existing IgG+ B cells in draining lymph nodes. Notably, our clinical studies reveal that the IN boost after IM vaccination elicits a robust IgA antibody response in humans. Thus, our cytokine-armed protein vaccine presents a promising strategy for inducing rapid and potent mucosal protection against respiratory viral infections.
Respiratory infections begin with invading through the upper respiratory tract. Lessons learned from the SARS-CoV-2 pandemic have shown that higher levels of nasal spike-specific secretory IgA (sIgA) correlate with a lower risk of reinfection. Previously, we found that nasal sIgA is 100 times more potent than serum IgG in neutralizing Omicron subvariants. As mucosal sIgA levels decline over time, then the risk of reinfection increases. Can a nasal vaccine be designed to induce mucosal sIgA? Can the risk of infection be predicted by assessing the level of sIgA in the nasal mucosa? We propose a precision vaccination strategy: a simple self-test strip to monitor sIgA levels using a nasal swab; if the sIgA falls to a low level, a nasal spray of a vaccine can be given. This precision vaccination strategy will provide convenient and effective protection to people in need.
The vaccination schedule has grown increasingly crowded, particularly for infants
Lack of space makes it challenging or impossible to introduce new life-saving vaccines
Combination vaccines may help by reducing crowding while reducing vaccine hesitancy
Challenges include formulation design, regulatory pathways, and how best to value combinations
Tuberculosis (TB) is the oldest and most deadly pandemic in history, still causing about 1.3 million deaths in 2022. BCG vaccination in humans results in the production of functional antibodies and long-lived memory B cell responses. We have showed that antibodies taken from protected healthcare workers (ie. individuals who were highly exposed to Mtb but remained uninfected) and transferred into mice could protect those mice against Mtb infection. It remains unknown which Mtb or BCG antigens induce protective antibody responses and what the mechanisms of such protective antibodies may be. In this study, two combinational antibody isolation methods were used to isolate the monoclonal antibodies against BCG/Mtb antigens. By the first method, the known protective antigens were used for mAbs isolation by single B cell isolation and Hybridima techniques, and the specific mAbs were isolated and the protective mAbs were identified by ex vivo and in vivo assay. By another method, the whole bacteria and the outer-membrane proteins of BCG were used, and then the B cells or the hybridoma technology was used to select the antibodies targeting the antigens. The protective functional activity of these mAbs were evaluated by using ex vivo and in vivo M.tb infection models, and the protective antigens were identified and used for the subunit vaccines development, which have shown protection in the mouse model. This research will promote a better understanding of host protective immune responses and the rational approach for the development of novel and effective TB vaccines.
- Overview of new high efficacy licensed R21/MM malaria vaccine
- Next steps for Oxford – SIIPL multi-stage malaria vaccines
- The road to elimination and eradication with new high-efficacy malaria vaccines
The worldwide outbreak of mpox virus (MPXV) in 2022 and the emergence and spread of a new strain, clade Ib, in Africa in 2024 highlight the threat of a sustained global epidemic of MPXV; however, the existing vaccines, attenuated virus vaccine and replication-deficient virus vaccine, have raised concerns about either their safety or efficacy. By using a structure-guided multi-antigen fusion strategy, we design a ‘two-in-one’ immunogen, DAM, containing the single-chain dimeric MPXV extracellular enveloped virus antigen A35 bivalently fused with the intracellular mature virus antigen M1. DAM preserved the natural epitope configuration of both components and resulted in stronger A35-specific and M1-specific antibody responses and more robust neutralizing antibody titers than either co-immunization strategy or live virus vaccination, collectively conferring effective in vivo protection from MPXV challenge. Moreover, DAM showed comparable systemic immune responses and in vivo protection with iteratively designed quadrivalent-chimeric immunogens, demonstrating the superiority of the design. Finally, faster tissue virus clearance was observed in the live virus vaccine-immunized group, accompanied by severe non-infectious tissue damage, suggesting a redundant immune response. We therefore propose a safer profile for protein vaccines than for live virus vaccines, again due to precise and effective immunization. These findings provide innovative insights and a promising vaccine candidate for the development of alternative vaccines against MPXV and other orthopoxviruses.
Assemblages of key immunologic features of viruses as highly repetitive particulate structures are essential for inducing potent and long-lasting antibody responses. Capitalizing on a novel function of RNAs as chaperone (Chaperna), here we provide a robust protein folding vehicle that could be implemented for virus-like particle (VLP) or nanoparticle (NP) assemblies in bacterial host. Here, tRNA functions as a ‘pace-maker’ for the assembly by controlling the overall kinetic network of antigen folding pathway into immunologically relevant conformation. Proof-of-concept was established for variety of NP vaccines, including H5N1 influenza, RSV, Dengue fever, West Nile, Japanese Encephalitis, VLP vaccines for Norovirus and subunit vaccine against pertussis. The Chaperna platform enables bacterial production and delivery of low-cost vaccines as a high-priority vaccine strategy against emerging and re-emerging viral infections.
The global outbreak of the 2022 monkeypox virus (Mpox) infection of humans raised public health concerns about the threat of human-to-human transmission of zoonotic diseases and the recent escalating outbreak of the deadly clade 1b Mpox in Africa triggered the declaration of a global public health emergency. At present, there is an unmet need to contain the outbreak due to some serious adverse reaction of the existing vaccines, to be confirmed efficacy against Mpox in at-risk populations and constrained vaccine supply. Development of a safe, more effective and scalable vaccine against Mpox is imminent to address this continental and global health crisis as quickly and equitably as possible. We have developed a novel mRNA vaccine candidate expressing four vaccinia viral antigens A27, L1, A33, and B5 in tandem in one molecule and evaluated the vaccine immunogenicity in rodent models. Immunization of animals with the candidate mRNA vaccine induced a potent cellular immune response and long-lasting antigen-specific binding antibody and neutralizing antibody responses in rodents. Strikingly, the neutralizing antibody responses against vaccinia virus (VACV) and Mpox were significantly stronger than the existing live attenuated vaccine. The mRNA vaccine completely protected mice from VACV induced fatality and significantly reduced pulmonary viral load and histopathology induced by VACV challenge. From a manufacturing perspective, the novel design of the mRNA vaccine facilitated a simplified manufacturing process with reduced cost but increased product competitivity. The results hold promise for this mRNA vaccine candidate to be used for protection of human in a Mpox pandemic.
The usefulness of live attenuated virus vaccines has been limited by suboptimal immunogenicity, safety concerns or cumbersome manufacturing processes and techniques. We developed proteolysis-targeting (PROTAR) vaccine technologies by using the host cell’s ubiquitin–proteasome system to manipulate stabilization and degradation of viral proteins of influenza viruses. We engineered the genome of influenza viruses in stable cell lines engineered for virus production to introduce proteasome-targeting domain(s), generating fully infective PROTAR viruses that were live attenuated by the host protein degradation machinery upon infection. In mouse and ferret models, PROTAR viruses were highly attenuated and able to elicit robust and broad humoral, mucosal and cellular immunity against homologous and heterologous virus challenges. The PROTAR vaccine approaches may be broadly applicable for generating live attenuated vaccines.
Lipid nanoparticles (LNPs) comprising mRNA are applicable as vaccines but also for a scope of therapeutic purposes. Despite of several initiatives to align on standard panels for quality assessment of such mRNA vaccines, discussions for identifying best and appropriate control strategies are still ongoing. So far, the focus has been mostly on the properties of the molecular properties of the individual components (like identity, content, integrity).
However important quality-related aspects of such mRNA vaccines derive from their colloidal nature. They are intrinsically polydisperse, multicomponent systems, formed by self-assembly between the respective moieties. Size dependent structural properties, drug loading and local chemical-physical coherencies inside the particles should be addressed.
In this presentation, biophysical approaches to get better insight into such chemical-physical properties with relevance for quality of the mRNA LNPs are presented.
Analyzing Lipid-based Nanoparticles (LNPs) as vectors presents various technical challenges stemming from their complex structure, small size, and encapsulation efficiency. Successfully evaluating the loading ratio and RNA distribution within these particles is crucial for identifying high-quality candidates and optimizing formulation strategies to minimize waste.
The NanoAnalyzer offers a comprehensive solution to overcome the hurdles inherent in LNP analysis. NanoFCM has demostrated the effectiveness of nFCM analysis in addressing the complicated challenges of LNP characterization, including efficacy of nanoparticle loading, mRNA quantification, and the surface density of various targeting modalities.
Lipid nanoparticles (LNPs) are the cornerstone of non-viral mRNA delivery systems, yet their therapeutic potential remains constrained by inefficient endosomal escape, with cytoplasmic delivery rates as low as 2%. Traditional approaches to enhancing endosomal release have primarily focused on chemical modifications of ionizable lipids. Here, we introduce a novel strategy centered on engineering the internal architecture within core-shell LNPs to substantially improve mRNA delivery efficiency. By utilizing ionizable lipid-coated gold nanoparticles (AuNPs) as a demonstrative core, we systematically optimized the LNP nanostructure, achieving a twofold increase in endosomal escape efficiency and a 100-fold enhancement in mRNA diffusion within the cytoplasm compared to conventional LNPs. This structural optimization also promotes more uniform and stable nanoparticle
assembly. In vitro studies demonstrated higher mRNA expression and transfection efficiency in HeLa and 293 cells treated with engineered core-shell LNPs. In vivo evaluations revealed a nearly fivefold increase in mRNA expression in murine models, alongside enhanced immunogenicity in SARS-CoV-2 spike-mRNA vaccines and therapeutic efficacy in a triple-negative breast cancer model. Comprehensive biocompatibility and biosafety assessments confirmed the favorable safety profile of the engineered LNPs. This internal architecture optimization framework provides a scalable and adaptable pathway for advancing mRNA therapeutics and vaccines, addressing a key bottleneck in endosomal release and paving the way for broader biomedical applications.
This talk will discuss the TLR9 pathway and novel CpG candidates that ParrBio has developed to unleash the potential of innate immune system to fight infectious diseases and cancer. We have shown that the novel type of CpGs can stimulate both humoral and cellular immunity and possess distinct characteristics comparing with the CpGs on the market. These novel types of CpGs have shown superiority when used as vaccine adjuvants and demonstrated potent anti-tumor activity in both animal models and in cancer patients. ParrBio is actively seeking global partners to advance its CpG compounds in vaccine development and cancer therapeutic drug application.
Vaccines have a long history as one of the most effective methods for the prevention of infectious diseases, but a lack of approved vaccine adjuvants hinders the development of efficacious subunit vaccines. The impact of the vaccine adjuvant AS01 on the efficacy (97%) of the Shingrix vaccine is an excellent example of what can be achieved with the optimal combination of recombinant antigen and adjuvant system. While a vaccine must be efficacious, an ideal vaccine should also be relatively easy to manufacture and stable within the existing supply chain in order to improve availability to both the developing and developed world. Our team has developed several 3rd generation pattern recognition receptor agonists capable of being formulated with a wide variety of vaccine delivery systems (emulsions, liposomes, inorganic nanoparticles, etc.) providing a deep toolbox to enable the optimal pairing of adjuvant and antigen. In the work presented here, we evaluated recombinant A/Victoria/2009 monovalent detergent split influenza antigen in combination with our novel toll-like receptor agonist INI-2002 in combination with QS21 saponin in our AS01-like formulation called T4Q, administered intramuscularly. T4Q induces Th1-biased antigen-specific antibody and T cell responses similar to commercial AS01. Additionally, T4Q adjuvanted vaccination provides protection from heavily drifted influenza challenge that is 100% lethal after vaccination with antigen only. In our novel model for measuring injection site pain, T4Q does not demonstrate increased injection site pain compared to AS01. Having validated this injection site pain model will enable us to evaluate novel formulations in an effort to reduce injection site pain.
Until recently, development of new human adjuvants was held back by poor understanding of their mechanisms of action and associated safety concerns. Major investment has led to renewed activity in the adjuvant field, resulting in multiple new adjuvant discoveries. Vaxine has successfully developed an extensive range of new vaccine adjuvants including polysaccharides (delta inulin), various small molecule and oligonucleotide agonists of toll-like receptor (TLR)-2, 4, 7, 9 and NOD2, many identified and optimised using our AI-based in silico high throughput drug screening approach - our experience in use of AI for immunomics research dating back over 25 years when Professor Petrovsky was a founder of the field of Immuno-informatics. These adjuvants alone and in combination can be used to tailor the immune response in any direction to get the desired outcome. However, adjuvants are just one piece of a successful vaccine, the other two pieces being the antigen platform and the delivery system. Vaxine has invested in optimizing each of these elements. It is utilising high yielding low-cost insect cell and C1 fungal protein expression platforms to produce its protein antigens, combining these with its proprietary adjuvants and then utilizing novel delivery systems including needle-free jet injectors, microneedle transdermal patches, aeosol lung delivery and intra-oral mucosal administration to ensure these are delivered to the right compartments to deliver a protective vaccine response. On top of this it is using AI to help speed the discovery and design of new antigens and adjuvant to feed this pipeline. This demonstrates major benefits in respect of enhanced protection when co-formulated with respiratory vaccines in animal models of influenza, SARS-CoV and tuberculosis, amongst many others. These adjuvants also have major effects on cellular and in particular, CD8 T cell immunity, with important implications for use in viral but also in cancer vaccines where induction of cytotoxic T cells is paramount. Thus the robust protection against respiratory pathogens afforded by these adjuvants when formulated with appropriate antigens can be ascribed to their ability to broadly enhance all arms of the adaptive immune response, resulting in generation of high avidity antibody and memory B cells as well as memory and effector CD4 and CD8 T cells.
The recombinant protein/polypeptide vaccine has become a new generation of vaccine technology, which will be widely used in the prevention and treatment of infectious diseases and tumors. However, the recombinant proteins/peptides need to be matched with appropriate adjuvants to become a valuable vaccine with especially cellular immunity. Adjuvants are a class of non-specific immune enhancers that can enhance the immunogenicity of antigens and change the type of immune response. The most widely used Alum adjuvants have good efficacy in increasing antibody immunity but are less effective in novel vaccines that require cellular immunity, such as tumor vaccines. In recent years, several novel innate immune agonists have been used in clinical trials for preventive and therapeutic vaccines. For example, the AS01 adjuvant developed by GSK, which combines two classes of agonists -MPLA and QS21- lipid nanoparticles, is successfully applied to the herpes zoster vaccine in 2018. Therefore, new adjuvants have become the core technology of the development pipeline of vaccine companies. Here, I will present our effort to develop new adjuvant formulation as nanoemulsion. We have obtained new nanoparticulate adjuvants without GS21 by using efficient agonists and formulation technique. The performance adjuvanted with antigens of VZV, Flu, RSV shows excellent antibody and cellular immunity with good safety.
Abstract: The development of high-purity antigens highlights the urgent need for novel adjuvants capable of triggering robust immune responses. Aluminum salts (Alum) are often employed as adjuvants but yield limited cellular immune responses. To address this limitation, Toll-like receptor (TLR) agonists have been utilized in combination with Alum. However, the current use of Alum and TLR agonists remains restricted to linear mixtures, and the interaction mechanism between TLR agonists and Alum is not well understood. In our study, we formulated combination adjuvants using aluminum oxyhydroxide nanorods (AlOOH NRs) and TLR agonists, such as CpG and Poly(I:C). The engineered combination adjuvants induce enhanced humoral and cellular immune responses in several antigen models, including HBsAg virus-like particles (VLPs), human papillomavirus (HPV) VLPs, and varicella-zoster virus (VZV) glycoprotein E (gE). Further mechanistic studies show that the formulation of combination adjuvants, such as the conjugation method, the orientation of the CpG molecule, and the molecular weight (MW) of Poly(I:C), determines the physicochemical properties and adjuvanticity of these combination adjuvants. Our study offers insights into adjuvant design to meet the formulation requirements for both prophylactic and therapeutic vaccines.
The development of next-generation vaccines has opened new frontiers in immunization strategies, particularly through innovative delivery methods such as nasal sprays and inhalable formulations. These novel approaches offer significant advantages over traditional injection-based vaccines, including improved patient compliance, enhanced immune responses, and the potential for rapid mass immunization during pandemics. Nanotechnology plays a crucial role in these advancements by enabling the creation of nanoparticle-based vaccines. These nanoparticles can serve as carriers for antigens, enhancing the delivery and stability of vaccines. They can also act as adjuvants, boosting the immune response by targeting antigen-presenting cells more effectively12. This presentation will explore the latest advancements in vaccine delivery technologies, focusing on the mechanisms, benefits, and challenges associated with nasal and inhalable vaccines, as well as the integration of nanotechnology. Additionally, we will discuss the implications of these innovations for global health, particularly in low-resource settings, and the future directions for vaccine research and development.
Respiratory syncytial virus (RSV), human metapneumovirus (hMPV) and parainfluenza virus 3 (PIV3) are medically important causes of respiratory tract infections. Combined these three viruses cause more severe disease and hospitalisations than influenza viruses. After more than 5 decades of unsuccessful research and development, vaccines have recently been approved for the prevention of lower respiratory tract disease caused by RSV, however vaccines for hMPV and PIV3 remain in early-stage development. The game changing development which lead to effective RSV vaccines has been discovery of methods to stabilize the RSV fusion glycoprotein (F) into the elusive prefusion conformation (preF).
The University of Queensland has developed a broadly applicable proprietary technology (molecular clamp), to facilitate preF stabilization not only for RSV but also hMPV and PIV3, and a diverse array of fusion glycoproteins from other viral families. In association with biotech spinout company, Vicebio Ltd, our team have identified lead candidate subunit vaccines for RSV, hMPV and PIV3, all of which have demonstrated, high yield, high stability and the ability to effectively elicit strong neutralizing immune response in animal models. The bivalent vaccine against RSV and hMPV (VXB-241) entered a phase I clinical trial in August 2024 and the trivalent formulation which also includes PIV3 (VXB-251) is completing pre-clinical development.
With three separate respiratory virus vaccines currently recommended for elderly populations (seasonal influenza, COVID-19 and RSV), the prospect of adding further vaccines for other high burden respiratory viruses such as hMPV or PIV3 into the schedule becomes problematic. Vicebio seeks to overcome this problem through the production of highly protective, multivalent vaccines in ready-to-use, liquid-stable formulations.
Compared with humoral immunity which blocks pathogen infection, cell-mediated immunity (CMI) clears infected cells to limit the replication and spread of pathogens. This increases vaccine efficacy against highly contagious (e.g., severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)) or latent (e.g., herpesvirus) pathogens. Although FDA-approved AS01B, AS01E and matrix-M adjuvants can induce potent CMI in subunit vaccines, they rely on QS21, a polysaccharide extracted from the bark of Quillaja saponaria. Because massive synthesis of QS21 is infeasible and Q. saponaria occurs only in South America, the supply of these CMI-inducing adjuvants is limited (e.g., approximately 20 million doses annually for AS01B), resulting in higher prices for the corresponding vaccines (approximately 150-200 USD per dose of ShingrixTM compared with other vaccines normally sold at 10-40 USD per dose).
The FDA has recently approved ionizable lipid nanoparticles (LNPs) for COVID-19 mRNA vaccines as carriers and oligodeoxynucleotides containing CpG motifs (CpG ODNs) for hepatitis B subunit vaccine as immunostimulators, both could be synthesized economically. We developed a novel LNP-CpG ODN adjuvant and tested its potency in different subunit vaccines. In varicella-zoster virus (VZV) vaccines, which use glycoprotein E as an antigen, this vaccine induced levels of CMI, which plays a decisive role in the efficacy of zoster vaccines, comparable to those of ShingrixTM in a VZV-primed mouse model that was adopted for preclinical studies of ShingrixTM and in non-human primates. In addition to potent humoral responses (approximately 10 times greater than those induced by alum adjuvants after 2 injections), Th1-oriented CMI was induced in respiratory syncytial virus (RSV) vaccines via the use of stabilized fusion glycoprotein (F) as an antigen, which may be helpful for lowering the risk of antibody-dependent enhancement of immunopathology. For rabies virus (RABV) vaccines, the surface glycoprotein (RABV-G) was used as an antigen, and IgG antibodies were induced within 7 days of primary vaccination (compared with 14 days with alum as an adjuvant). Prompt-induced humoral immunity and potent CMI that are helpful for eradicating infected viruses may work synergistically for increasing RABV vaccine efficacy.
In conclusion, LNP-CpG ODN adjuvants are helpful for inducing prompt, potent humoral immunity and potent CMI for subunit vaccines
As the global demand for rapid, scalable, and cost-effective vaccine production grows, Baiya Phytopharm has emerged as a leader in plant-based vaccine technologies. Our novel vaccine platform harnesses the power of plants to produce vaccines faster and more sustainably than traditional methods. This presentation will showcase the science behind Baiya's platform, including its speed, scalability, and potential to address pandemics and rare diseases. We will also discuss our latest achievements, such as the development of COVID-19 vaccine candidates, and explore the future of plant-based biologics in global healthcare.
I would like to discuss the vaccine technologies for nasal vaccine and mRNA vaccine.
· Overview of what is known about local and systemic symptoms post vaccination. Ex of adjuvanted and mRNA vaccines
· Recent data at University of Geneva on mechanisms of reactogenicity of mRNA vaccines in humans and mouse models (collaboration with Moderna)
· Key message: both vaccine-specific and host intrinsic factors contribute to reactogenicity
· Perspectives for the development of improved vaccines
mRNA vaccines have revolutionized the response to infectious diseases, as demonstrated during the COVID-19 pandemic. However, these vaccines face significant challenges, including suboptimal delivery efficiency and high reactogenicity, leading to reduced vaccine acceptance. Our preliminary studies show that General Therapeutics' Next-generationiLDC LNPs can reduce pro-inflammatory cytokine levels by 50% and enhance mRNA expression up to 8-fold compared to traditional formulations, and more importantly being 70% less pain and tissue damage. mRNA vaccines formulated with our iLDCs will improve efficacy and reduce adverse reactions. Our LNP technology has the potential to significantly improve the safety and effectiveness of mRNA vaccines. By overcoming the limitations of current mRNA vaccines, this project aims to enhance vaccine safety and efficacy, addressing mRNA vaccination hesitancy, ultimately contributing to better global health outcomes.
Circular RNA (cRNA) vaccine is a promising alternative to the canonical linear RNA vaccine. Compared to linear RNA, cRNA has a longer half-life and could potentially be more thermostable and does not require extreme storage and transportation temperature. The goal of this study is to evaluate this novel cRNA platform through the development of a vaccine against Nipah virus. We assessed various cRNA encoding for the full-length (NiV-FL) or only the ectodomain of Nipah glycoprotein G in vivo and found that one of the cRNA-NiV-FL elicited better antibody and neutralizing antibody responses in a dose-dependent manner. Next, we evaluated the effect of various LNP for encapsulation of the cRNA in vivo and found that all of the novel LNP-encapsulated cRNA elicited higher antibody response in mice when compared to a clinically approved LNP. In conclusion, we have successfully performed preclinical proof of concept of a cRNA vaccine against Nipah. Future experiments involved further development of this cRNA vaccine into a viable and cost-efficient vaccine product.
We have successfully developed a sophisticated VZV mRNA vaccine by optimizing its antigen truncation, RNA sequence, and vaccination approach. Our study demonstrates that the RNA sequence optimized Full-length gE protein inoculated intradermally executes a better immunogenicity.
Porcine reproductive and respiratory syndrome viruses (PRRSV) cause significant economic losses in the global pig industry. Live attenuated PRRSV vaccines (MLV) are widely used but are weakly immunogenic and provide limited protection. There is therefore a pressing need to develop more efficacious next generation vaccines. I shall present three examples of novel approaches we have or are pursuing: (i) evaluation of the induction of broadly protective cellular immunity; (ii) augmenting protection by engineering MLV to express immune checkpoint inhibitors; and (iii) the application of structural vaccinology to develop a vaccine capable of inducing broadly neutralising antibodies.
-Adjuvants induce innate immune responses that correlate with adaptive responses
-There is increasing evidence that some of these innate responses are accompanied by chromatin changes in monocytes, giving rise to the phenomenon of trained immunity
-Deciphering the molecular pathways and signalling targets can inform rational design of novel adjuvants, including those that can be combined with mRNA/LNP formulations
-Connecting in-depth understanding of adjuvant immunity can inform design choices and research directions for mRNA 2.0
1. Background of pseudotype technologies
2. Building pseudotype platforms
3. Immunogenicity readouts for broadly-reactive vaccines
4. Novel directions of pseudotype technology
The COVID-19 pandemic led to an unprecedented event, all people woridwide were exposed for the first time to the same virus, SARS.CoV.2 Wuhan, creating a globally shared original antigenic sin (OAS). However, during the course of the COVID-19 pandemic several varianis emerged exposing the human immune system to numerous antigenically distinct spike (S) proteins, the main target neutralizing antibodies. This unceasing interplay between SARS-CoV-2 variants and the human immune system has led to a continuous maturation of the B cell compartment rising questions on how the SARS-CoV-2 Wuhan OAS memory B cell response evolvedcontroemerging variants. To shed light on the impact of SARS-CoV-2 0AS on B cellimmunity we longitudinaly analyzed at single celIevel spanel of almost 1,000 neutralizing human monoclonal antibodies (nAbs) isolated from COVID-19 vaccinees or people with hybrid immunity. Our analysis revealed that the Wuhan OAS,drove convergent maturation and expansion germlines(GHV3.53/3-66) which were restor to neutralize SARS-CoV-2 Omicron variants. In addition, we observed that after breakthrough infection with the antigenical distant Wuhan Omicron, people expanded new B cell germlines not derived by the Wuhan OAS to tackle SARS-CoV-2 variates. In spite of B cell maturaion,the uN.1 Omicron varianls, by introducing a single substitution in the S proteln (L455S) compared to its initial subineage, evaded the recently restored lGHV3-53/3-66 germlines. Our work decoded the cryptic role of OAS in COVID-19 and highlights the unceasing interplay between SARS-CoV.2 and the human immune system which may be a never-ending game for the next decades.
Dr. Bin Wang is the Co-founder, Chairman of Advaccine Biotechnology Co LTD. He is also holding a distinguished professor position at the Fudan University School of Basic Medical Sciences and serves as the chairman for the Nucleic Acid Vaccines branch of the Chinese Vaccine Society. His research area is focused on the effects of therapeutic vaccination to activate T cells and the mechanism of immune regulations. He has developed novel adjuvants and recombinant vaccines, novel DNA vaccine delivery, and led to several developed vaccines being tested in human clinical trials. He received his Ph.D. from the Cincinnati Children's Hospital at the University of Cincinnati School of Medicine in 1990. He completed his postdoc training in virology and immunology at the Wistar Institute in 1992 in Philadelphia. He became an instructor and assistant professor at the University of Pennsylvania Medical School from 1993 to 1998. He was a professor and served as the Chairman of the Department of Microbiology and Immunology for six years at the College of Biological Sciences, China Agricultural University before he joined Fudan University. He was one of the very early DNA vaccine technology inventors in the 90’s and performed the first-in-human DNA vaccine trials in 1994-1996. He has been involved in several clinical trials of therapeutic vaccines against chronic HBV infections in recent years and invented a novel prophylactic RSV vaccine currently under clinical phase II testing. He has published over 160 peer-review articles and awarded 35 US and 30 Chinese patents. He serves as an editorial board member for several international journals and executive member in several professional societies.
Professor Adrian V. S. Hill FRS is the Director and Founder of the Jenner Institute, and Mital Professor of Vaccinology at Oxford University. He is a passionate believer in the power of molecular medicine to address many of the most egregious health care inequities globally. His group have been leaders in the development of adenoviral and other vaccines against infectious diseases and he has tested these in extensively in over eighty clinical trials in Africa and Europe. In partnership with the Serum Institute of India and AstraZeneca the Jenner Institute developed rapidly a ChAdOx1 vector-based SARS-CoV-2 vaccine which saved an estimated 6.2 million lives in 2021 alone.
His lab also designed a newly licensed high efficacy malaria vaccine, R21/Matrix-MTM, which has recently shown unprecedented high efficacy in a phase III trial in four African countries, again in partnership with the Serum Institute of India and also Novavax Inc. This vaccine promises to make a major impact on reducing the 500,000 childhood deaths from malaria each year. In 2021 he was elected a Fellow of the Royal Society and is a Knight Commander of the Order of the British Empire (KBE).
George Fu Gao has been a key leader in the public health field, making remarkable contributions to research and discovery through basic research, clinical evaluation and advocacy. He has made many remarkable contributions to the scientific field of control and prevention of emerging infectious diseases. He obtained his DPhil degree from Oxford University, UK and did his postdoc work in both Oxford University and Harvard University (with a brief stay in Calgary University). Gao worked in Beijing Agricultural University (1986-1991), Oxford University (2001-2006), Institute of Microbiology, Chinese Academy Sciences (2004-2008, Director-General). China CDC (Director-General, 2017-2022), National Science Foundation of China (Vice-President, 2018-2022). Gao is a member (academician) of Chinese Academy of Sciences (CAS), an international member of the U.S. National Academy of Sciences (NAS), a foreign member of the U.K. Royal Society (RS), a member of the German National Academy of Sciences Leopoldina, a fellow of African Academy of Sciences and a fellow of The World Academy of Sciences (TWAS).
Dr. Dan Barouch received his Ph.D. in immunology from Oxford University and his M.D. from Harvard Medical School. He is currently the William Bosworth Castle Professor of Medicine at Harvard Medical School, Director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center, a member of the Ragon Institute of MGH, MIT, and Harvard, and part of the Bill & Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery. His laboratory focuses on studying the immunology and pathogenesis of viral infections and developing novel vaccine and treatment strategies. His group has led the development of vaccine candidates for multiple pathogens of global significance, including HIV, Zika virus, tuberculosis, and most recently SARS-CoV-2. His work contributed to the development of the Johnson & Johnson COVID-19 vaccine and the evaluation of multiple COVID-19 vaccines and monoclonal antibody therapeutics. He was elected to the National Academy of Medicine in 2020 and received the King Faisal Prize in Medicine in 2023.
Dr. Berlanda Scorza is an accomplished pharmaceutical executive with a strong focus on translating scientific innovations into tangible patient benefits. He currently serves as Vice President of Global Health R&D Vaccines at GSK. Additionally, he is the Chairman of the Board and General Manager of the GSK Vaccines Institute for Global Health, as well as a member of the GSK Country Executive Board in Italy.
Before joining GSK in 2020, Dr. Berlanda Scorza held senior leadership roles at the Bill & Melinda Gates Foundation and PATH, where he led key programs focused on the development of seasonal and pandemic influenza vaccines.
Earlier in his career, Dr. Berlanda Scorza was a senior scientist at Chiron Corporation and Novartis Vaccines, where he contributed to the development of innovative vaccine technologies, including a replicon RNA vaccine, the cell-cultured influenza vaccine Flucelvax, and the bacterial vaccine platform GMMA. Dr. Berlanda Scorza earned his Ph.D. from the University of Milano-Bicocca and completed his post-doctoral research at Imperial College London.
Rajinder as CEO-DCVMN International is responsible for leadership, governance, strategic vision and overall operational excellence of DCVMN. Rajinder is appointed as member GAVI’s Vaccine Investment Strategy (VIS) Steering Committee 2024, a permanent member of CEPI’s Joint Coordination Group (JCG), 2023-24, member PAVMs Talent Development WS and Regional Vaccine Manufacturing Collaborative (RVMC). To meet an un-precedented challenge posed by COVID-19, Rajinder has been actively involved in all global strategic initiatives along with COVAX partners-WHO, GAVI, CEPI, UNICEF and several other international organizations including industry associations to ensure equitable and timely access to vaccines. He has been member of several advisory expert groups including COVAX Manufacturing & Supply Chain Task Force Leadership Team, G-20 Health Working Group and Market Design and Demand Intelligence pillar of PAVM. Rajinder has over 25 years of top management experience in the industry including at the Board of Directors of the Indian subsidiary of Sanofi Pasteur and as CEO-Panacea Biotec. He has served as Member-GAVI-PPC as well as Vice-President, DCVMN Executive Committee.
Dr. Raman Rao joined as the Chief Executive Officer at Hilleman Laboratories in February 2020. Dr. Rao has more than two decades of experience in research and development, manufacturing and commercialisation of vaccines for infectious diseases in global pharma and biotech companies. Prior to joining Hilleman Laboratories, Dr. Rao served as the Vice President of Global Product Operations with Takeda, Singapore, where he enhanced the global product portfolio while successfully leading an international team across Japan, Singapore and the United States. The teams worked in the areas of dengue, norovirus, zika, polio and other vaccines.
Dr. Rao started his career in 2002 with Shantha Biotechnics Limited, part of Sanofi Aventis Group in India, in Clinical Research and Scientific Affairs. He holds a MD in Medical Microbiology from the Postgraduate Institute of Medical Education and Research.
He plans to carry forward Dr. Maurice Hilleman’s legacy for providing effective solutions for global health, especially those impacting low- and middle-income countries.
Dr. Hun Kim is the President of Global Business at SK Bioscience. His role is to oversee the company's product and platform portfolio in a comprehensive perspective from R&D to commercialization through global alliance and external innovation.
Dr. Hun Kim started his biopharmaceutical career in 1992 as a researcher at Green Cross Corporation, In 2000, he moved on to Berna Biotech, a part of Crucell at present. In 2008, he joined SK Chemicals,the parent company of SK Bioscience, and lead the company's expansion in vaccine R&D, Quality and manufacturing capabilities.
Under his oversight, the company developed and received approval for cell culture-based influenza vaccines (SKYCellflu/SKYCellflu Quadrivalent), varicella/herpes zoster vaccines (SKYVaricella/SKYZoster),and Pneumococcal Conjugation Vaccines. During the Pandemic, it successfully manufactured and supplied COVID-19 vaccines developed by AstraZeneca and NovaVax. With support from CEPI and BMGF, SK Bioscience also developed its own COVID-19 vaccine (SKYCovione), which became the first domestically developed COVID-19 vaccine to be approved in Korea.
Ms. WANG is responsible for the company's overall commercial operation in both China and Overseas markets. She has 23 years experience in pharmaceutical industry and holds a bachelor degree in Economics, a master degree in engineering of Peking University and Global EMBA of CEIBS. Jeanne joined the Company in 2012 and made outstanding achievements in multiple roles such as Head of HR, Head of Operation, Vice President of Strategy & Business Development and Chief Financial Officer. She helped the company set up the management system of financing, financial operations, human resources and commercialization. After completing several rounds of Pre-IPO fund raising, Ms. Wang also successfully led the Company’s IPO on Main Board of Hong Kong Stock Exchange in 2019 and on the Sci-tech Innovation Board of the Shanghai Stock Exchange in 2020, making the Company the first “A+H” dual listing vaccine company.
Dr. Berlanda Scorza is an accomplished pharmaceutical executive with a strong focus on translating scientific innovations into tangible patient benefits. He currently serves as Vice President of Global Health R&D Vaccines at GSK. Additionally, he is the Chairman of the Board and General Manager of the GSK Vaccines Institute for Global Health, as well as a member of the GSK Country Executive Board in Italy.
Before joining GSK in 2020, Dr. Berlanda Scorza held senior leadership roles at the Bill & Melinda Gates Foundation and PATH, where he led key programs focused on the development of seasonal and pandemic influenza vaccines.
Earlier in his career, Dr. Berlanda Scorza was a senior scientist at Chiron Corporation and Novartis Vaccines, where he contributed to the development of innovative vaccine technologies, including a replicon RNA vaccine, the cell-cultured influenza vaccine Flucelvax, and the bacterial vaccine platform GMMA. Dr. Berlanda Scorza earned his Ph.D. from the University of Milano-Bicocca and completed his post-doctoral research at Imperial College London.
Dr. Dan Barouch received his Ph.D. in immunology from Oxford University and his M.D. from Harvard Medical School. He is currently the William Bosworth Castle Professor of Medicine at Harvard Medical School, Director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center, a member of the Ragon Institute of MGH, MIT, and Harvard, and part of the Bill & Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery. His laboratory focuses on studying the immunology and pathogenesis of viral infections and developing novel vaccine and treatment strategies. His group has led the development of vaccine candidates for multiple pathogens of global significance, including HIV, Zika virus, tuberculosis, and most recently SARS-CoV-2. His work contributed to the development of the Johnson & Johnson COVID-19 vaccine and the evaluation of multiple COVID-19 vaccines and monoclonal antibody therapeutics. He was elected to the National Academy of Medicine in 2020 and received the King Faisal Prize in Medicine in 2023.
Dr. Linfa Wang is a professor of the Programme in Emerging Infectious Diseases at Duke-NUS Medical School, and the inaugural executive director of PREPARE, Ministry of Health, Singapore. He is an international leader in the field of emerging zoonotic viruses and virus-host interaction. In response to the COVID-19 pandemic, he has served and is serving on multiple WHO committees for COVID-19, including the WHO IHR Emergency Committee. Prof. Wang has more than 500 scientific publications. He was the Editor-in-Chief for the Virology Journal from 2112-2022. Prof. Wang was elected to the Australian Academy of Technological Sciences and Engineering in 2010, the American Academy of Microbiology in 2021 and the Australian Academy of Sciences in 2023. He received the Singapore President Science Award in 2021
Dr. Chen is a prominent scientist specializing in human vaccine research and antiviral therapies. He currently serves as the Chief Operating Officer at RuenHuei Biopharmaceuticals Inc., where he oversees the development and production of new vaccine candidates. Dr. Chen joined RH Biopharma in August 2018, bringing over a decade of practical industry experience in vaccine development. Before his role at RH Biopharma, Dr. Chen held several key positions at Adimmune Corporation, including the Director and Manager of the R&D Department. At Adimmune, he was instrumental in developing the EV71 vaccine and advancing a cell culture-based production process for influenza vaccines. Dr. Chen's academic background includes a Ph.D. from National Yang-Ming University in Taipei, Taiwan, where he specialized in Biochemistry and Molecular Biology. He also completed postdoctoral fellowships at the Genomics Research Center, Academia Sinica, and the Vollum Institute at Oregon Health and Science University in the United States. His research has significantly contributed to the field of vaccine development, particularly in creating more effective influenza vaccines and understanding the immune responses to viral infections. He is currently also special technical expert at the Department of Pharmacy at National Taiwan University and an associate professor at the Department of Chemistry at National Chung Hsing University
梁重阳教授专注于重组蛋白大分子药物开发领域,多年从事药物作用机制相关结构生物学研究及理化分析工作,主导研发多项创新型单抗药物和亚单位疫苗,通过成果转化与企业合作推动管线在美国FDA和中国NMPA获批临床试验或上市。
Professor Linqi Zhang is the Director of the Comprehensive AIDS Research Center at Tsinghua University. Prof. Zhang's research focuses on HIV-1 pathogenesis and vaccine development, and has recently expanded to the field of emerging and re-emerging human viral pathogens such as SARS-CoV-1/2 and MERS-CoV. Using cutting-edge antibody and combinatorial antigen library techniques, Prof. Zhang’s research aims to characterize protective antibody immunity in infected humans and rational design of effective vaccines and therapies against the viral infection. Professor Zhang is the recipient of the National Outstanding Young Scientist Award, privileged Changjiang Professorship, and Bayer and Vanke Chair professor. He has published extensively and is among the most cited Chinese researchers in the field of microbiology and immunology. Professor Zhang has also served as a member of national expert and advisory board to the Chinese government and several international organizations on HIV/AIDS and infectious diseases,and was recently elected as a Foreign Fellow of the African Academy of Sciences.
-17年疫苗临床行业经验 n前广西疾控疫苗临床研究所所长(2010-2022),管理和实施过近300个临床试验,70+个疫苗临床试验PI,多个大型疫苗多中心效力试验leading PI。
-CDE药审专家和国家专班专家,曾参与编著和讨论多个国家疫苗临床试验相关法规、技术指导原则,多次参加重大新药创制科技重大专项课题。 n曾作为PI主持:全球首个人二倍体细胞EV71灭活疫苗、国内首个mRNA新冠疫苗、HPV疫苗、轮状病毒疫苗、微卡、狂犬疫苗、IPV、bOPV、流感、肺炎疫苗、流脑疫苗等。
-在国际期刊发表30+篇SCI论著,疫苗学第七版翻译编委、预防性疫苗临床试验设计与实施编委。
-曾任国家局药品注册审评专家委员会委员、国务院联防联控机制科研攻关组疫苗研发专班专家组成员、国家免疫规划技术工作组成员、中华预防医学会疫苗临床专业委员会常委、原国家级和省级GCP检查员。
Dr. Tan is responsible for drug discovery, preclinical development, translation research and external collaboration in China. Dr. Tan got his Ph.D. in Molecular Medicine from UT Health Science Center San Antonio and received his Postdoctoral training with Dr. Michael Karin at UC San Diego. Dr. Tan worked in Pfizer and Novartis for 9 years, specialized in drug discovery and translational research, bridging preclinical research to early clinical trials. Dr. Tan worked at Biosion Biotech and Coherent Biopharma before he joined Clover. Dr. Tan was selected as Jiangsu Innovation and Entrepreneur Talent and Suzhou Innovation and Entrepreneur Leading Talent.
Dr. Shibo Jiang is a Professor at the Shanghai Institute of Infectious Disease and Biosecurity of Fudan University, Shanghai, China. His main research interest is the development of antiviral drugs and vaccines. He has published 572 papers (total IF: 7,662, average IF: 13.4) in SCI journals such as Cell (x3), Nature (x2), Science (x2), Lancet (x4), CNS’ sister journals (x71), with total 45,327 citations and an h-index of 105. He has applied for 104 patents, 54 of which were issued, and 11 of them were licensed out with 3 classes of innovative drugs and medical products used in clinics.
Dr. David Weiner directs a translational research laboratory at The Wistar Institute in the area of Molecular Immunology. His group is one of the pioneering research teams in establishing the field of DNA vaccines and immunotherapies. Important reports from his lab include the first DNA vaccine studied for HIV as well as for cancer immunotherapy, the early development of DNA encoded genetic adjuvants including the particularly relevant IL-12, advances in gene optimization, and advances in electroporation (EP) technologies resulting in improved gene delivery among others. His group worked with collaborators to become the first to move DNA technology into human study. His laboratory’s work helped revitalize the field through advancement of new synthetic DNA design and modification of EP delivery approaches resulting in potent immune induction as well as the first successful Phase IIb DNA efficacy study (for HPV immunotherapy) in humans. Dr. Weiner is the recipient of numerous honors including election as a fellow to both the American Association for the Advancement of Science in 2011 and the International Society for Vaccines in 2012. He is the recipient of the NIH Director’s Transformative Research Award and received the Vaccine Industry Excellence Award for Best Academic Research Team in 2015 at the World Vaccine Congress. Weiner was honored with the prestigious Hilleman Lectureship in 2015 at the Children’s Hospital of Philadelphia Grand Rounds session and received a Stone Family Award from Abramson Cancer Center for his groundbreaking work on DNA vaccines for cancer immunotherapy. In 2019, Dr. Weiner was honored with the Scientific Achievement Award from Life Sciences PA (LSPA). Dr. Weiner returned to Wistar in 2016 from his position at The University of Pennsylvania School of Medicine as professor of Pathology and Laboratory Medicine. From 1990 to 1993, Weiner held a joint position as assistant professor of Pathology and Laboratory Medicine at The Wistar Institute and the University of Pennsylvania School of Medicine. Dr. Weiner is a co-founder of Inovio Pharmaceuticals and is a member of the Board of Directors. Dr. Weiner graduated with a B.S. in biology from SUNY at Stony Brook, N.Y., a M.S. in biology from the University of Cincinnati and a Ph.D. in developmental biology from the University of Cincinnati College of Medicine.
Ruben Rizzi, physician by training, SVP of Global Regulatory Affairs at BioNTech. I joined the company in December 2019 just before the pandemic, and I have been the global regulatory lead for BioNTech for our COVID-19 development. Currently, I am still supporting the lifecycle of our COVID-19 vaccine, and I am co-leading the Global Regulatory Affairs department at BioNTech and working closely with the teams that are responsible for the development of BioNTech´s pipeline, post-approval activities and labelling
英博博士于2019年创立艾博生物,为公司创始人、董事长兼首席执行官。创立至今,艾博生物已建立起具有自主知识产权的mRNA和纳米递送技术平台,推动mRNA科学技术应用赋能创新医疗产品开发。
英博博士拥有国际化的行业视野和丰富的核酸药物开发领域工业界经验,精通RNA药物设计和纳米制剂产业化。创立艾博生物前,他曾在多家全球领先的核酸药物研发机构任核心研发团队负责人,领导开展包括小核酸(siRNA)、mRNA及基因编辑产品的开发及大规模工业化生产等工作。
英博博士本科、硕士毕业于复旦大学,并在美国东北大学获得药剂学博士学位。英博博士曾在Cell、Lancet等多个重要国际期刊发表论文,他也是多项海外授权专利发明人。2018-2019年期间,英博博士任波士顿美中生物医药协会(Chinese-American BioMedical Association)会长,服务生物医药科研和工业技术的深度融合。
陆汉新博士获乔治华盛顿大学遗传学博士学位,在生物医药产品开发领域拥有16年开拓性经验。他领导多学科团队推动治疗性与预防性疫苗技术平台创新,其开创性工作涵盖两大方向:开发针对高胆固醇血症等代谢紊乱及神经退行性病变的免疫治疗疫苗;设计新一代疫苗以应对呼吸道合胞病毒(RSV)、大流行流感、埃博拉病毒等新发传染性病原体。
陆博士的科学领导力贯穿疫苗研发全链条:从发现阶段的靶点验证、理性抗原设计及佐剂优化,到临床前开发的动物模型开发、机制研究与药效学分析,到生物标志物分层指导的I-III期临床试验,以及病毒学特性表征及符合GLP规范的疗效/安全性评估。
Doctor Hu is the founder, chairman and full-time CEO of Anda Biology. She was a former researcher of the Chinese Academy of Sciences Shanghai Institute of Nutrition and Health, visiting scholar of the Max-Planck-Institute for Molecular Genetics in Germany, and visiting scholar of the Cambridge Molecular Biology Laboratory in the UK. She independently undertook key projects of the National Natural Science Foundation of China and 863 projects as the project leader, participated in the Super 973 projects, the Chinese Academy of Sciences' Leading Special Research on Stem Cell and Regenerative Medicine, and the National Twelfth Five Year Plan Major Special Projects. Expert in the Second Review of Outstanding Youth Fund, Outstanding Youth Fund, and Key Projects of the National Natural Science Foundation of China, and expert in risk assessment of the Ministry of Science and Technology in 2013.
She has been engaged in molecular genetics research of diseases for a long time and has established a series of genetic analysis techniques that can be applied to stem cell clinical transformation research such as stem cell quality control, in vivo genetic tracing, stem cell maintenance, and cell phenotype transformation, laying the foundation for stem cell based disease diagnosis and treatment. Dr Hu has published more than 70 SCI papers and won the first prize for scientific and technological progress in Shanghai (second place completion).
She has participated as the leader of the innovation team in 2018 in the first Shenzhen Women's Innovation and Entrepreneurship Competition. After winning the award, she founded Anda Biology Medicine Development (Shenzhen) Co., Ltd and she is serving as its full-time CEO. In the past four years, she has led the company's employees to develop personalized immunotherapy vaccine for pancreatic cancer, universal cancer vaccines, cell therapy and other products. Among which, PCNAT-1, a therapeutic personalized vaccine for pancreatic cancer, has won the FDA orphan drug qualification certification.
Dr. Bin Wang is the Co-founder, Chairman of Advaccine Biotechnology Co LTD. He is also holding a distinguished professor position at the Fudan University School of Basic Medical Sciences and serves as the chairman for the Nucleic Acid Vaccines branch of the Chinese Vaccine Society. His research area is focused on the effects of therapeutic vaccination to activate T cells and the mechanism of immune regulations. He has developed novel adjuvants and recombinant vaccines, novel DNA vaccine delivery, and led to several developed vaccines being tested in human clinical trials. He received his Ph.D. from the Cincinnati Children's Hospital at the University of Cincinnati School of Medicine in 1990. He completed his postdoc training in virology and immunology at the Wistar Institute in 1992 in Philadelphia. He became an instructor and assistant professor at the University of Pennsylvania Medical School from 1993 to 1998. He was a professor and served as the Chairman of the Department of Microbiology and Immunology for six years at the College of Biological Sciences, China Agricultural University before he joined Fudan University. He was one of the very early DNA vaccine technology inventors in the 90’s and performed the first-in-human DNA vaccine trials in 1994-1996. He has been involved in several clinical trials of therapeutic vaccines against chronic HBV infections in recent years and invented a novel prophylactic RSV vaccine currently under clinical phase II testing. He has published over 160 peer-review articles and awarded 35 US and 30 Chinese patents. He serves as an editorial board member for several international journals and executive member in several professional societies.
Xiangrong Song is a full professor at Sichuan University and a pharmaceutical scientist at National Key Laboratory of Biotherapy. The Song lab has developed the targeted delivery systems for gene drugs and small molecules to treat tumors, atherosclerosis, ocular diseases, infection or brain diseases. Two novel drug candidates (IND) have been approved for phase I clinical trials. She has authored more than 100 papers and is an inventor of more than 50 issued / pending patents worldwide. The technologies that Dr. Song and her colleagues have developed formed the basis for the launch of 2 biotechnology companies. The two companies are translating the aforementioned academic innovations toward commercialization and societal impact. In 2019, she was a recipient of the first prize of Science and Technology Award in Chinese National Medicine Association, for the research on immune function of Yi nationality's medicine. In 2022, she was named as the elite of science and technology in China.
Dr. Joon Haeng Rhee is a graduate of Chonnam National University Medical School and received PhD from the same university. He has been working on molecular microbial pathogenesis and vaccine biology for more than 30 years. His team was the first reporter of the whole genome sequence of V. vulnificus, which became one of the most widely used standard strains in the Vibrio research field. Vaccine study was first started aiming the high mortality V. vulnificus infections. During the vaccine research, his team came across the finding that a flagellin protein of V. vulnificus has an excellent mucosal adjuvant activity in late 1990s. Now flagellin is applied to the development of effective vaccines and immunotherapeutics against diverse diseases such as cancers, allergies, and Alzheimer’s disease. He served the president of Korean Vaccine Society (KVS) from 2013 to 2015. He was elected as an ISV Fellow and serves a member of ISV Executive Board. He is currently the director of Clinical Vaccine R&D Center and Combinatorial Tumor Immunotherapy Research Center of Chonnam National University. As of November 2023, he has more than 170 papers published in peer-reviewed journals and named as an inventor on 40 patents.
Rajinder as CEO-DCVMN International is responsible for leadership, governance, strategic vision and overall operational excellence of DCVMN. Rajinder is appointed as member GAVI’s Vaccine Investment Strategy (VIS) Steering Committee 2024, a permanent member of CEPI’s Joint Coordination Group (JCG), 2023-24, member PAVMs Talent Development WS and Regional Vaccine Manufacturing Collaborative (RVMC). To meet an un-precedented challenge posed by COVID-19, Rajinder has been actively involved in all global strategic initiatives along with COVAX partners-WHO, GAVI, CEPI, UNICEF and several other international organizations including industry associations to ensure equitable and timely access to vaccines. He has been member of several advisory expert groups including COVAX Manufacturing & Supply Chain Task Force Leadership Team, G-20 Health Working Group and Market Design and Demand Intelligence pillar of PAVM. Rajinder has over 25 years of top management experience in the industry including at the Board of Directors of the Indian subsidiary of Sanofi Pasteur and as CEO-Panacea Biotec. He has served as Member-GAVI-PPC as well as Vice-President, DCVMN Executive Committee.
Peter Dull is the deputy director for Integrated Clinical Vaccine Development within the Global Health Division. In this role, he provides technical and strategic guidance on clinical development to the foundation’s program strategy teams, including Pneumonia and Enteric and Diarrheal Diseases, and external partners. In addition, he leads the foundation’s vaccine development activities for HPV vaccines, including efforts with reduced dose schedules.
Peter joined the foundation in 2014 after 10 years at Novartis Vaccines and Diagnostics where he was the clinical franchise head for Meningitis and Sepsis Vaccines. During that time, he led the clinical development and global licensure for a quadrivalent meningococcal glycoconjugate vaccine (Menveo; MenACWY-CRM) as well as a protein-based serogroup B meningococcal vaccine (Bexsero; 4CMenB). His work also included early clinical development of Group B strep glycoconjugate and Staph aureus vaccines. Prior to joining Novartis, he was an epidemic intelligence service officer in the Meningitis and Special Pathogens Branch at the U.S. Centers for Disease Control and completed subspecialty training in infectious diseases at Emory University.
He received his medical degree at University of Wisconsin-Madison and Internal Medicine training at Oregon Health Sciences University.
袁瑗女士是帕斯适宜卫生科技组织(PATH)上海代表处中国国家代表。她负责管理PATH与中国伙伴的合作关系,并为PATH在中国提供管理和业务发展支持。她于2007年1月加入PATH,担任过包括项目管理、行政财务官员等多项职务,在疫苗领域从业18年间,参与了乙脑疫苗世卫组织预认证、轮状疫苗开发、肺炎结合疫苗开发和培训、OPV海外临床、Sabin IPV D抗原国际标准制定、HPV疫苗预认证等项目,熟悉疫苗生命周期的生产、质量、临床、药政、药物警戒、生物安全等多个方面。2023年1月,袁瑗女士被选举为中国疫苗行业协会疫苗国际合作促进分会第一任秘书长。在加入PATH之前,她在新加坡Integrity Metals公司担任项目经理并在印尼工作。袁女士在北京大学获得文学学士、工商管理硕士和公共卫生硕士学位。
张骞,深圳康泰生物国际事业部总经理,中国疫苗行业协会疫苗国际合作促进分会委员,毕业于同济大学经管学院和法国ESSEC商学院,负责公司国际商务拓展、国际注册和国际合作工作。曾成功引进包括人二倍体细胞狂犬疫苗生产技术、灭活脊灰疫苗生产技术等多个核心疫苗生产技术。同时与多个新兴市场国家开展了产品海外商务拓展、注册和申报工作,已向东南亚、南亚、中东等国家出口部分产品的成品和中间产品,并正在推进在东南亚、南亚、中东、拉丁美洲、独联体、非洲等国家的成品注册、原液分装和技术转移工作。同时与驻华使领馆、跨国药企、国际研究所、国际组织等展开了丰富的交流与合作。
Ms Adel Sattarova holds Specialist Degree in Pharmacy. She has been working at the Saint Petersburg Scientific Research Institute of Vaccines and Serums (FSUE SPbSRIVS FMBA of Russia) since 2016 and currently holds a Head of Project Management Department position. Ms Adel Sattarova has an experience in regulatory affairs, leads the projects, one of which is the WHO prequalification of the influenza vaccine FLU-M® – the product developed and produced by FSUE SPbSRIVS FMBA of Russia with a production site in Saint Petersburg, Russia and Managua, Nicaragua.
Dr. Hun Kim is the President of Global Business at SK Bioscience. His role is to oversee the company's product and platform portfolio in a comprehensive perspective from R&D to commercialization through global alliance and external innovation.
Dr. Hun Kim started his biopharmaceutical career in 1992 as a researcher at Green Cross Corporation, In 2000, he moved on to Berna Biotech, a part of Crucell at present. In 2008, he joined SK Chemicals,the parent company of SK Bioscience, and lead the company's expansion in vaccine R&D, Quality and manufacturing capabilities.
Under his oversight, the company developed and received approval for cell culture-based influenza vaccines (SKYCellflu/SKYCellflu Quadrivalent), varicella/herpes zoster vaccines (SKYVaricella/SKYZoster),and Pneumococcal Conjugation Vaccines. During the Pandemic, it successfully manufactured and supplied COVID-19 vaccines developed by AstraZeneca and NovaVax. With support from CEPI and BMGF, SK Bioscience also developed its own COVID-19 vaccine (SKYCovione), which became the first domestically developed COVID-19 vaccine to be approved in Korea.
Melanie Saville, MBBS, is PATH’s Chief Scientific Officer. She leads PATH’s product development division, which includes a global team dedicated to the development, introduction, and scale of vaccines, medical devices, and diagnostics.
Dr. Saville is a distinguished physician specializing in virology with more than two decades of experience developing and licensing vaccines for global use. Her contributions over the past 20 years have included the development of vaccines for seasonal and pandemic influenza, as well as pediatric combinations and vaccines against rabies, Japanese encephalitis, dengue, Ebola, and SARS-CoV-2.
Before joining PATH, Dr. Saville worked with the Coalition for Epidemic Preparedness Innovations (CEPI), where she served as the Executive Director of Vaccine Research and Development, leading technical teams supporting vaccine development. She also served as the R&D and manufacturing workstream leader for COVAX, part of a global collaboration to speed development, production, and equitable access to COVID-19 tests, treatments, and vaccines.
Dr. Saville holds a medical degree, a master’s degree in medical virology, and a Bachelor of Science in molecular biology from University College, London.
Rita Carsetti trained in Medicine and Obstetrics and Gynecology at La Sapienza University of Rome (Italy) before discovering her passion for science during her postdoctoral training in the United States, at the M.D. Anderson Hospital in Houston (Texas). She followed this with a second postdoc at the Max-Plank Institute for Immunobiology in Freiburg (Germany), in the department of Georges Koehler, who had received the Nobel Prize for the discovery of monoclonal antibodies. At the Max-Planck she also became responsible for the flow cytometry core facility and later worked in the departments of Michael Reth and Thomas Boehm. After 13 years in Germany, she returned to Italy (Bambino Gesù Children’s Hospital, Rome) with a strong background in basic immunology of murine B cells. At this point she turned her attention to human B cells for a more patient-orientated research approach. The close contact with clinicians and her role as head of the Diagnostic Immunology Unit gave her the possibility to learn how human B cells change with age, immunodeficiency, infection, transplantation, and vaccination. The COVID-19 pandemic and the global vaccination campaign gave her the possibility to learn more about the development, function, and persistence of human memory B cells after vaccination in healthy subjects and patients with primary or secondary immunodeficiencies. Throughout her career, Rita Carsetti has made a number of discoveries regarding the development of human and murine B cell populations and the effect changes in such populations have on infection and immunodeficiencies in humans. Her recent work on SARS-CoV-2 and RNA vaccination has been vital in demonstrating how human memory B cells aid immune protection and how mucosal immunity is induced in neonates born to SARS-CoV-2 infected mothers. Altogether, Rita Carsetti’s work is extremely relevant to both basic and clinical immunologists.
Ph.D. in Molecular Virology from Wageningen University, the Netherlands. Formerly served as a researcher at the Vaccine and Infectious Disease Organization-International Vaccine Centre (VIDO-InterVac) in Canada, the Australian National University, and the University of Amsterdam, focusing on the molecular pathogenesis of influenza virus, respiratory syncytial virus, and baculovirus, as well as vaccine development for respiratory diseases. Currently employed at CanSino Biologics Inc. as a Senior Scientist in the R&D Center. Leading and driving major R&D projects and international collaborations within the company. As a project leader, working on the development of an inhaled adenovirus-vectored tuberculosis vaccine and dedicated to advancing mucosal vaccines and novel vaccine delivery technologies.
Hua Peng, Ph.D., Principal Investigator at the Guangzhou National laboratory (GNL). Dr. Hua Peng graduated from Peking University, Health Science Center with a bachelor's degree, and completed his doctoral and postdoctoral training in virology at the State University of New York at Buffalo and the National Institutes of Health (LVD/NIAID/NIH). Prior to joining GNL, Dr. Peng held positions as associate Prof./Prof./PI at the Institute of Biophysics, Chinese Academy of Sciences. Her research focuses on 1) Investigating host immune response to virus infection, viral pathogenic mechanism, and virus-associated malignancy; and 2) Developing innovative preventive and therapeutic vaccines against viral infections and immune based anti-cancer drugs. Dr. Hua Peng has made important scientific and translational achievements, publishing in prestigious journals including Gut, Cell Res., Sci Immun., JEM, JCI, Gastro, Nat Commun., PNAS, Nat Med, Nat Immun., Hepatology, Clin Can Res, JI, JBC, and JV. Prof. Peng’s team invented a new-generation SARS-CoV-2 recombinant vaccine, leading to the approval of the vaccine product V-01 and its iterative vaccine BV-01-QX for emergency use in collaboration with Livzon Bio.
魏霞蔚,四川大学华西医院研究员,博导,长江学者特聘教授,国家优秀青年基金获得者。 2010年毕业于浙江大学药物制剂系毕业获得学士学位,于四川大学华西药学院药剂系毕业获得博士学位。现任四川大学华西医院国际合作与交流办公室·港澳台事务办公室主任。任国家老年疾病临床医学中心副主任,华西医院老年与衰老医学研究室主任。任美国基因与细胞治疗协会分委会委员,任亚太地区基因/细胞治疗联盟青年主席。主要研究方向包括:重组蛋白疫苗与佐剂研发、鼻喷疫苗与新型疫苗递送系统、肺部炎性疾病与肿瘤免疫微环境研究、抗肿瘤小分子药物的转化研究等。在 Nature、Nature Communications、EMBO Molecular Medicine、Advanced Science、Molecular Cancer、ACS Nano等发表SCI论文,其中以通讯作者或第一发表SCI论文110篇(H-index=56)。担任4种SCI杂志的编委(Editorial Board Member)或副主编,获得2018年药明康德学者奖。
Dr. Chen has been a Professor at the State Key Lab of Respiratory Disease, Guangzhou Medical University since 2013. Dr. Chen received a medical degree from Shanghai Medical College in 1984. He obtained a Ph.D. in Biochemistry and Molecular Biology from Indiana University School of Medicine. Dr. Chen completed his postdoctoral training at Dana-Farber Cancer Institute, Harvard Medical School. From 1997-2001, Dr. Chen served as a Senior Research Fellow at Merck Research Laboratories, where he was the first inventor of Merck's Ad5-based AIDS vaccine that entered clinical trials worldwide. Dr. Chen served as Vice President of R&D for GlaxoSmithKline in 2009-2011 and as Vice President at Sanofi Pasteur in 2012. Dr. Chen has over 200 publications in infectious diseases, vaccine research, and cancer research. His current research is focused on vaccine and antibody research on adenovirus, influenza virus, and emerging viruses. Since 2020, Dr. Chen has been working on developing user-friendly intranasal vaccines and mucosal immunity.
Christopher Gill has an MD from the University of Massachusetts Medical School and an MS from the Tufts School of Graduate Biomedical Studies. Dr. Gill is an infectious disease specialist by training. From 2002-2008 and again from 2011-2023 he was a faculty member of the Department of Global Health at Boston University School of Public Health rising eventually to the level of full professor of Global Health. During the intervening years 2008-11 he was the clinical director for the development of the MenACWY-CRM conjugate meningitis vaccine for Novartis Vaccines and Diagnostics. His work has centered broadly on child-survival in the areas of diarrheal diseases, pneumonia, and neonatal survival. However, his largest concentration of work has focused on better understanding the epidemiology of pediatric respiratory infections, notably Streptococcus pneumoniae, Bordetella pertussis and Respiratory Syncytial Virus. At BU, Dr. Gill was the 2015 recipient of the Norman Scotch Award for excellence in teaching at Boston University School of Public Health, and the 2016 recipient of Boston University's Metcalf Cup and Prize. The Metcalf Cup and Prize is BU's highest teaching honor and is awarded to one of BU's >3500 faculty across its 17 colleges and schools each year. At the Gates Foundation, Dr. Gill’s main areas are development of combination vaccines and expanding the impact of HPV vaccination globally.
顾江,陆军军医大学国家免疫生物制品工程技术研究中心副主任、教授,博士生导师,国家重点研发计划首席科学家,“国防优才基金”获得者,军队高层次青年英才,陆军科技英才,陆军军医大学科研名师,享受军队优秀专业技术人才津贴。国家重点领域严重感染致病菌疫苗研发创新团队核心骨干;重庆英才创新创业示范团队核心骨干。中国疫苗行业协会细菌感染与疫苗研究专委会常委、秘书长,重庆微生物学会理事。先后获重庆市技术发明一等奖、军队科技进步二等奖等奖励。主要从事结构疫苗学基础与临床研究,围绕超级耐药菌的免疫干预展开,研制了1.1类新药——基因工程铜绿假单胞菌疫苗实现成果转化,合同金额2.8亿元。
Graduated with a Ph.D. in Bioinformatics from the University of Science and Technology of China in 2014, under the guidance of Professor Liu Haiyan. Many years of experiences in molecular dynamics simulation and high-throughput sequencing, and have served as the Director of Bioinformatics for Micro Spin Genes and the Head of Nucleic Acid Drug Development for Yidu Cloud. Successfully developed multiple clinical high-throughput data analysis platforms and have authored multiple invention patent authorizations and SCI papers. As the co-founder of Therarna, responsible for identifying and optimizing upstream targets of mRNA drugs, leading the team to develop a systematic platform for identifying cross species cellular immune epitopes, designing humoral immune antigens, and optimizing mRNA sequences.
李浩,中国农业大学动物医学院副教授,博士生导师。2017年7月在清华大学获得理学博士学位。2017年7月到2019年7月在清华大学医学院从事博士后研究工作。2019年7月至今,在中国农业大学动物医学院从事结核病免疫学和抗生素耐药性相关研究。主持国自然面上和中国博士后基金各1项,国家重点研发计划研究任务1项,参与国自然3项。以第一或通讯作者(含共同)在Nature Reviews Immunology,PNAS,Nature Communications,npj Vaccines等杂志发表相关文章30余篇。
Markus is Head of Analytical Development, Microbiology, and Quality Control for the MAP-Program at LTS Lohmann Therapie Systeme AG in Andernach. He studied biology at Philipps University in Marburg, Germany, and was awarded a PhD in Parasitology in 2009 for his work on the membrane physiology and biochemistry of the Malaria parasite. From 2009 to 2015 he expanded his track record in infectious disease research at The Australian National University in Canberra, Australia. In 2015, he accepted a position for the University of Oxford, leading the Clinical Pharmacology laboratories at the Mahidol-Oxford Tropical Medicine Research Unit in Bangkok, Thailand. In 2019 he joined LTS as Head of Analytical Development, Microbiology and Quality Control for the MAP Program.
Mr. Lake has worked in vaccine manufacturing and commercialization for 30 years developing diverse experience at global leaders Merck and GlaxoSmithKline. Mr. Lake's background includes live virus and recombinant vaccine bulk production, sterile filling, and quality control, before moving into product management and business development roles. He served as the manufacturing Alliance Manager between Merck and Sanofi Pasteur during the startup of their European loint Venture and worked for several years as asenior level commercialization consultant in the vaccine industry.
Professor Adrian V. S. Hill FRS is the Director and Founder of the Jenner Institute, and Mital Professor of Vaccinology at Oxford University. He is a passionate believer in the power of molecular medicine to address many of the most egregious health care inequities globally. His group have been leaders in the development of adenoviral and other vaccines against infectious diseases and he has tested these in extensively in over eighty clinical trials in Africa and Europe. In partnership with the Serum Institute of India and AstraZeneca the Jenner Institute developed rapidly a ChAdOx1 vector-based SARS-CoV-2 vaccine which saved an estimated 6.2 million lives in 2021 alone.
His lab also designed a newly licensed high efficacy malaria vaccine, R21/Matrix-MTM, which has recently shown unprecedented high efficacy in a phase III trial in four African countries, again in partnership with the Serum Institute of India and also Novavax Inc. This vaccine promises to make a major impact on reducing the 500,000 childhood deaths from malaria each year. In 2021 he was elected a Fellow of the Royal Society and is a Knight Commander of the Order of the British Empire (KBE).
Lianpan Dai, PhD, Principal Investigator at Institute of Microbiology, Chinese Academy of Sciences. He received his doctor's degree from Technical University of Munich (TUM), Germany. His research is mainly focused on the design and development of novel vaccines against major pathogens and the mechanism of protective immune response. Important research and translational achievements have been made in the research and development of vaccines against coronaviruses, Zika virus and other emerging infectious diseases, among which the recombinant protein subunit COVID-19 vaccine has been approved for use in many countries. The results are published as first/corresponding authors in the journals including Cell, The New England Journal of Medicine, Lancet, Nature Immunology, Nature Reviews Immunology, Cell Host & Microbe. He is supported by the National Science Fund for Excellent Young Scholars, and is the winner of VCANBIO Award for Biosciences and Medicine, excellent member of the Innovation Promotion Association of Chinese Academy of Sciences, the Young Scholar Award of Chinese Society of Immunology, and China Patent Silver Award Winner.
王寒,北京大学未来技术学院副研究员,疫苗研究团队负责人。主要从事病毒感染机制和抗病毒干预策略研究,在包括埃博拉病毒、猴痘病毒和非洲猪瘟病毒在内的多种重要病毒性传染病原的入侵和复制机制、疫苗、抗病毒药物研究中取得了一系列重要进展。以第一和通讯作者(含共同)在Cell、Nature Immunology、PNAS、Nucleic Acids Research等国际期刊上发表论文多篇,获“2016年度中国生命科学领域十大进展”。入选博士后创新人才支持计划、北京市科协“青年人才托举工程”、中国科学院青年创新促进会;任 hLife 期刊青年编委,北京慢性病防治与健康教育研究会感染性疾病专业委员会委员。
Christopher Obwanga is currently the East Africa Regional Manager at P95 Africa, bringing over 15 years of experience in clinical trials within the EMEA region, with a particular focus on sub-Saharan Africa. Throughout his career, Christopher has held multiple roles including leadership positions at IQVIA and Roche.
Dr. Xu Gelin, senior expert of Wuhan Institute of Biological Products (WIBP), experienced on vaccine development for nearly 40 years.
Baik-Lin Seong, PhD, is a Distinguished Professor of Yonsei University College of Medicine, and Director General of Vaccine Innovative Technology ALliance (VITAL)-Korea. He received B.S. from Seoul National University (1977), M.S. from KAIST (1979), PhD from MIT (1988). He worked as postdoctoral scientist at the University of Oxford (1988-1992).
He served as a member of the Presidential Advisory Council of Science & Technology of Korean Government (2021-2022) and the Scientific Advisory Board of International Vaccine Institute (IVI) (2018-2022). He chaired the COVID-19 Vaccine Pan-Government Strategic Plan of the Korean Government (2020-2023).
With a view to ensure equitable access of effective vaccines to LMICs, he works on developing a low-cost production platform of VLP/nanoparticle vaccines against RSV, norovirus, nipah, universal influenza vaccine, and flavivirus vaccines including Japanese Encephalitis, Zika, and West Nile viruses.
Dr. Yelin Xiong is the Vice President at Yither Biotech Co. Ltd. In this role, she is responsible for early-stage discovery to clinical material manufacturing of various vaccine candidates. Yelin has extensive research experience in immunology and vaccine development against infectious diseases. Prior to the current position, Yelin had over 20 years of industry experience in research, process development/scale-up, GMP manufacturing and CMC management in Sanofi pasteur. She received a Doctorate degree in Immunology and Cell Biology from John Curtin School of Medical Research, Australian National University and had postdoctoral training in Emory University and University of Toronto.
George Fu Gao has been a key leader in the public health field, making remarkable contributions to research and discovery through basic research, clinical evaluation and advocacy. He has made many remarkable contributions to the scientific field of control and prevention of emerging infectious diseases. He obtained his DPhil degree from Oxford University, UK and did his postdoc work in both Oxford University and Harvard University (with a brief stay in Calgary University). Gao worked in Beijing Agricultural University (1986-1991), Oxford University (2001-2006), Institute of Microbiology, Chinese Academy Sciences (2004-2008, Director-General). China CDC (Director-General, 2017-2022), National Science Foundation of China (Vice-President, 2018-2022). Gao is a member (academician) of Chinese Academy of Sciences (CAS), an international member of the U.S. National Academy of Sciences (NAS), a foreign member of the U.K. Royal Society (RS), a member of the German National Academy of Sciences Leopoldina, a fellow of African Academy of Sciences and a fellow of The World Academy of Sciences (TWAS).
Shaowei Li Ph.D. Professor of Biochemistry and Structural Vaccinology, Xiamen University Shaowei Li is a tenured Professor of Biochemistry and Structural Vaccinology in the School of Life Sciences with a joint appointment in the School of Public Health, Xiamen University, China. He is the vaccine group leader in the National Institute of Diagnostics and Vaccine Development in infectious diseases (NIDVD), one of the academic leaders in the State Key Laboratory of Molecular Vaccinology and Diagnostics, deputy director in Fujian provincial Xiang An biomedicine laboratory. Dr. Li has inter-disciplinary research interests focusing on structural vaccinology, resulting in more than 120 peer-reviewed papers. He also has translational experience in vaccine development against infectious diseases—such as Hepatitis E vaccine and HPV vaccine, especially in aspects of immunogen design, process development and antigen characterization. Dr. Li has won two of China’s National Science and Technology Awards and been listed in the Top 20 translational researchers of 2016, ranked by Nature Biotechnology. He has served on the Product Development for Vaccines Advisory Committee (PDVAC), World Health Organization (WHO) since 2022.
司龙龙博士,中国科学院深圳先进技术研究院合成生物学研究所研究员、博士生导师,定量合成生物学全国重点实验室副主任,国家高层次人才(青年),国家重点研发计划首席科学家。博士毕业于北京大学,在哈佛大学Wyss研究所、哈佛医学院完成博士后研究工作。实验室研究方向包括合成生物学驱动的疫苗技术、人类器官芯片、抗病毒药物。发表论文约50篇,其中代表性研究成果以通讯作者、第一作者(含共同一作)发表于Science、 Nature Biotechnology、Nature Microbiology、Nature Biomedical Engineering、Nature Chemical Biology、Science Advances、Nature Communications等专业期刊,申请和授权专利20余项。
Prof. Ken J. Ishii, M.D., Ph.D., currently Director for Int. Vaccine Design Center, The Institute of Medical Science, the University of Tokyo, has 27 years of experience in Vaccine R&D since 1998 including 7 years as a IND reviewer at US Food and Drug Administration (FDA), 15 years as a basic immunologist at Osaka University, 9 years as a vaccine adjuvant expert at National Institute (NIBIOHN), 2 years as managing director at AMED (medical funding agency), as well as Advisor for PMDA (regulatory agency), GHIT (global fund) and CEPI. He has contributed to basic research on infectious diseases and immunology, resulted in numerous books and over 250 periodical publications and 35,000 citations with H-index 84 as well as over 50 patents related to vaccine and adjuvant, and to regulation of many vaccines and guidelines for vaccine preclinical and clinical trials in Japan and US.
Yoshimasa Takahashi, PhD, graduated from University of Tokyo. He received his postdoctoral training at the University of Maryland at Baltimore, where he worked on understanding the basic mechanisms for humoral immune memory and antibody responses. He joined the National Institute of Infectious Diseases (NIID) in Japan, and became Director at the Department of Immunology. He was appointed to Director of the Research Center for Drug and Vaccine Development, NIID in 2021. He also holds the position of Guest Professor at seven universities. In this role, he trains graduate students in Immunology and Vaccinology.
Dr. Takahashi's research focuses on comprehending lymphocyte biology to unravel the humoral and cellular immune responses that underly vaccine effectiveness. By implementing high-throughput approach for human antibody analysis and isolation, he has identified novel classes of broadly protective antibodies against influenza, SARS-CoV-2, and other viruses. Multiple R & D for next-generation of vaccines and antibody therapeutics are on-going based on these findings.
Dr Norbert Pardi holds a Ph.D. in biochemistry and genetics. He has been working at the University of Pennsylvania since 2011 and currently holds an Assistant Professor position at the Department of Microbiology of the Perelman School of Medicine. His research interest is the development of mRNA-based therapeutics with particular focus on new generation infectious disease vaccines. He explored the development of a novel vaccine platform using nucleoside-modified mRNA in lipid nanoparticles (LNPs) and used it to generate highly effective vaccines targeting various pathogens (influenza virus, coronaviruses, malaria and others). Dr. Pardi is a pioneer of the nucleoside-modified mRNA vaccine technology and published milestone papers in the field.
Heinrich Haas, Department of Biopharmaceutics and Pharmaceutical Technology Johannes Gutenberg-Universität, Mainz Mainz, Germany. Ph.D. in the group of Prof. Dr. Helmuth Möhwald at Johannes-Gutenberg Universität Mainz. Researched lipid membranes and organized bio-molecular systems. In pharmaceutical industry (Munich Biotech, Medigene, BioNTech) developed different types of nanoparticle products to clinical stage. Focus on advanced approaches for nanoparticle development and control.
李亚霏博士毕业于香港大学医学院,南山领航人才,主要从事纳米制剂的研发与工艺开发,在Cell Discovery、Small、Nano Research等国际知名学术期刊上发表论文6篇,申请相关专利10余个。现就职于瑞吉生物,担任研发总监,负责了多个管线的制剂开发,主导搭建了mRNA-LNP冻干工艺平台,完成首个国内获得IND批件的冻干mRNA-LNP工艺开发。
Ph.D. in Cellular and Molecular Biology by Oswaldo Cruz Foundation and the AIDS Vaccine Research Lab (UW-Madison-USA). Currently, she manages the RNA Vaccine Development Partner Center for PAHO/WHO at Bio-Manguinhos-FIOCRUZ, focusing on the development and manufacturing of RNA-based vaccines and therapies in Brazil. This initiative aims for regional self-sufficiency in vaccine R&D and production, democratizing the RNA platform for Latin America and the Caribbean. Awarded by Women in Science of PDA Brazil (2021) and SIBEN-Argentina (2022), she has 18 years of experience in Immunology, Vaccine and Biotherapeuticals Development, Public Health, and Equity.
Ruben Rizzi, physician by training, SVP of Global Regulatory Affairs at BioNTech. I joined the company in December 2019 just before the pandemic, and I have been the global regulatory lead for BioNTech for our COVID-19 development. Currently, I am still supporting the lifecycle of our COVID-19 vaccine, and I am co-leading the Global Regulatory Affairs department at BioNTech and working closely with the teams that are responsible for the development of BioNTech´s pipeline, post-approval activities and labelling
王娜,毕业于中国农业大学,任职厦门福流生物科技有限公司应用工程师,负责单分子纳米流式检测技术相关应用开发和售前技术支持工作,在新型疫苗递送方面具有扎实的理论基础和丰富的表征经验。
高 尚
深圳源兴基因技术有限公司mRNA技术平台负责人
本硕博就读于吉林大学,获分析化学博士学位。进入制药行业以来,先后从事 重组蛋白药物、单克隆抗体药物、多肽药物、体内基因编辑、RNA 相关药物及 递送系统的质量研究和控制工作。类型涵盖创新药、仿制药,具备研发端至生产端质量相关经验。持续专注于分析方法开发、分析方法生命周期管理及产品的质量控制。
Dr. Yuhong Cao is a scientist and principal investigator at the National Center of Nanoscience and Technology, Beijing, China. She earned her B.S. in Chemistry from Linfield College in Oregon, USA, and her Ph.D. in Materials Science and Engineering from Stanford University, California. Under the mentorship of Professor Nicholas Melosh, her doctoral research focused on developing a nondestructive nanostraw system for longitudinal living cell sampling. Following her Ph.D., Dr. Cao pursued postdoctoral training in T cell engineering by applying CRISPR-Cas technology. She worked with Professor Peidong Yang, in partnership with Professor Jennifer Doudna at the University of California, Berkeley. She then returned to Stanford University for a second postdoctoral fellowship with Professor Steven Chu, focusing on in vivo single-molecule tracking. At the National Center of Nanoscience and Technology, Dr. Cao leads a research group specializing in Nanomaterials and Plant Cell Surface Interfaces. Her work aims to develop universal intracellular delivery systems for natural plants to accelerate plant breeding. By exploring nanomaterials to facilitate effective gene editing using CRISPR technology, her lab addresses the critical need for efficient delivery systems in plants. This research has the potential to significantly shorten plant breeding cycles, enabling ultra-fast breeding and advancing agricultural innovation.
Dr Sandy Douglas is a principal investigator and academic clinician. He led the development of the large-scale manufacturing process for the Oxford-AstraZeneca COVID-19 vaccine, which has resulted in over 2 billion doses being manufactured by late 2021. Sandy is Chief Investigator of the COV008 phase I clinical trial of intranasal administration of this vaccine. He holds a Wellcome Trust Clinical Research Career Development Fellowship, is a Co-Investigator on the EPSRC funded Future Vaccine Manufacturing Research Hub (Vax-Hub) and holds an MRC grant to develop a novel rabies vaccine and carry out clinical trials.
Jingxin Li, PhD, Professor, is working at Jiangsu Provincial Center for Disease Control and Prevention. Her research is focused on vaccine clinical evaluation and immunization strategy. She has participated in a lot of epidemiology investigations and a series of clinical trials of novel vaccines, including Enterovirus type 71 vaccine, recombinant human Ad5 vectored Ebola vaccine, and Covid-19 vaccines. She has got National Natural Science Outstanding Youth Founds and Jiangsu Provincial Natural Science Funds for Distinguished youths, and hosted or participated in seven National Natural Science Founds or National Science and Technology Major Projects. She has published over 25 articles in medical journals on vaccine clinical studies, including Nature Med, Lancet Respir Med, Lancet Glob Health, etc.
35年行业经验
曾任中、美、欧药企高管,包括Amador,Worg,Alexion(AstraZeneca),Shire (Takeda),CancerVax (Amgen) 及Elan (Perrigo)
长期从事质量法规、医学临床,兼甲方乙方工作经验
前FDA/CBER 评审
Dr. Eric Tsao has served as the Chief Executive Officer of Synermore Biologics since the founding of the company in 2013. He has over 25 years of direct experience with more than 20 products in clinical development, four US and EU approved products on the market, and eight biotech manufacturing facilities. His areas of expertise include biological product development, process design, facility engineering, and operations. Under his leadership, SYN023, an innovative anti-rabies monoclonal antibody cocktail, has been expertly developed and commercialized for rabies post-exposure prophylaxis. Since 2008, Dr. Tsao has worked with Morningside Group on biotech investments. He was instrumental in enhancing portfolio companies’ CMC capabilities. Dr. Tsao was the Vice President of Technical Operations at Aeras, a Gates Foundation sponsored vaccine development organization. At MedImmune, Dr. Tsao rose to the position of Vice President of Process and Manufacturing Sciences responsible for process development as well as manufacturing of monoclonal antibodies and recombinant vaccines. The development and manufacturing efforts led to the successful licensing of Synagis, FluMist, and Cervarix. He was a process development scientist at Johnson & Johnson, where he focused on the development of cell culture processes and start-up of the commercial manufacturing facility for erythropoietin. Dr. Tsao received his Ph.D. in Chemical Engineering from the University of Michigan.
Adham began his professional journey as a neuroscientist, followed by a shift to a commercial career at GSK Vaccines. He possesses over 15 years’ experience in commercialising biological therapeutics in the emerging markets namely Middle East and Africa, South East Asia and South America. He was responsible for obtaining emergency use approval for a prominent Chinese Biotech in the United Arab Emirates prior to China’s Approval. Having led biotech and clinical firms to achieve more than $250 million in revenue over the past 5 years. In addition to having established numerous start- ups, overseeing concept, value proposition, market analysis, business modeling, product development and securing investments. A seasoned health technology expert boasting years of experience in Machine learning and AI in the healthcare space.
Meng LI has been leading the International business team of CNBG since 2013, oversees CNBG’s international cooperation and registration activities. She also serves on the board of CNBG-Virogen, and the board of Emerging Biopharmaceuticals Manufacturers Network (EBPMN). During her 19 year experiences in biological industry, she established extensive networks with academia, NGOs, enterprises internationally, and successfully completed a number of landmark projects. Including the bOPV capacity expansion and prequalification program with BMGF (received over 23Million USD financial supports from BMGF, prequalified by WHO in 2019), establishment of CNBG’s first JV with foreign enterprise, the first overseas acquisition by CNBG, roll-out of the Covid-19 vaccine PhIII trials in 6 countries and its registration in over 100 countries. Meng Li has successfully signed a number of in-license, research cooperation, commercialization and industrialization projects with NIH, Oxford, France Institut Pasteur, PATH, IVI, biotech companies and developing country manufacturers. She worked as temporary advisor to WHO inspectorate during WHO’s first inspection to China NMPA in 2010, and was elected as the executive committee member of DCVMN from 2014-2016.
Hani Kim is the Executive Director of the RIGHT (Research Investment for Global Health Technology) foundation, with 16 years of work experience in translational health research as an academic research scientist and at global health R&D funding organizations. She completed her PhD in Lab Medicine and Pathobiology at the University of Toronto, Canada and post-doctoral training in molecular immunology of B cells at the Max-Planck Institute of Immunology, Germany.
During her MPH and her affiliation as a Research Associate at the Johns Hopkins School of Public Health, Hani trained researchers at icddr,b, Bangladesh and KEMRI, Kenya. Prior to joining the RIGHT foundation, she developed and managed portfolios of vaccine discovery grants and molecular surveillance grants as a Gates Fellow initially and later as a Program Officer at the Bill & Melinda Gates Foundation for six years.
Hani has published articles in translational medical research and in the political origins of health inequity. Her recent articles include "The Selangor Consensus: strengthening clinical trials for local public health in the Western Pacific", ‘‘We need people’s WHO to solve vaccine inequity, and we need it now”, “The sociopolitical context of the COVID-19 response in South Korea”, and “A critical assessment of the ideological underpinnings of current practice in global health and their historical origins.”
As Senior Director at Sanofi Vaccines External R&D, Sean is responsible for the identification and evaluation vaccine-related opportunities to support Sanofi Vaccines’ global pipeline strategy. Under his leadership, Sanofi Vaccines has completed three research agreements, initiated over 10 feasibility studies with both academic and industrial partners, organized 4 full due diligence, executed two global licensing agreements with biotech companies, and reached a 280 million AUD collaboration agreement with Queensland State Government. Sean has over 20 years of extensive vaccine R&D and business development experience. Before joining Sanofi, Sean was Co-Founder and Chief Operating Officer at Altravax from 2013 to 2015 and Executive Director & Head of the Vaccine Research Institute at Simcere Pharmaceutical Group from 2010 to 2013. Prior to Simcere, he worked as a Senior Scientist and Project Leader on multiple vaccine programs at Maxygen for 9 years. Sean received his Ph.D. degree in Biological Sciences from the University of Delaware, M.S degree in Microbiology from the Institute of Microbiology, Chinese Academy of Sciences, and B.S. degree in Microbiology from Shandong University. He received his postdoctoral training at Columbia University.
Dr. Xinzhong (Jon) Wang, Ph.D. currently serves as the Global R&D President and CSO of Parr Biotechnology (He Bei) Co. Ltd.
He was the Founder and CEO of Fusion Bioscience (Cayman) Inc. incorporated in November 2021. Fusion Bioscience merged with Parr Bio in 2023. Dr. Wang is a scientific leader with over 20 years of experience in oncology research and drug development. He has extensive knowledge and experience in tumor immunology, molecular and cell biology, drug target discovery, animal modeling, and protein therapeutics development. He has published more than 30 original scientific papers in prestigious journals and is the inventor of several international patents.
Prior to Parr Bio, Dr. Wang served as Senior Vice President and Chief Scientific Officer at CStone Pharmaceuticals (HK02616); Director of Immuno-Oncology research at Merck & Co.; Associate Director of BioSuperiors at AstraZeneca/MedImmune; Principal Scientist at Biogen.
Dr. Wang obtained a Bachelor of Science degree in Biochemistry from Nankai University and a PhD in Molecular and Cellular Biology from Ohio University. He completed his post-doctoral training in Gene Therapy at Harvard Medical School/Massachusetts General Hospital and subsequently served as an Instructor of Medicine at Harvard Medical School.
Juhienah Khalaf is a medicinal chemist with expertise in the synthesis and development of bioactive compounds, including antifungal agents, immunomodulators, and protease inhibitors. With a strong background in organic and combinatorial chemistry, Juhienah has contributed to advancing research in therapeutic molecules targeting immune responses and infectious diseases. Her work spans the design and synthesis of TLR4 agonists, small-molecule drugs, and immuno-based therapeutics. Juhienah's research has been instrumental in the development of novel adjuvant systems and targeted therapies, aiming to address critical challenges in immunology and infectious disease treatment. Juhienah first synthesized INI-2002, a TLR4 agonist that has become the lead component in Inimmune's Adjuvant Systems. This work is presented at the Vaccine Industry Forum (VIF) conference, highlighting its potential in enhancing vaccine efficacy through targeted immune modulation.
Yongming Chen received his Master degree of chemistry in 1990 from Northwest University, Xian. In 1993, he obtained his Ph.D. on polymer science from Nankai University, Tianjin. From 1994 to 1998, he was Postdoctoral Researcher and later Research Assistant at the Institute of Chemistry, CAS. Then he spent the period 1998−2001 as Postdoctoral Researcher in the University of Düsseldorf and the University of Mainz. Since 2001, Chen was Professor at the Institute of Chemistry CAS. He moved to Sun Yat-sen University in 2013 and he works in Henan University in 2024. He obtained the “Distinguished Young Scholars” by the National Science Foundation of China (2006) and the “Wang Bo-Ren Polymer Research Award” by the Chinese Chemistry Society (2011). He served for Polymer, an Elsevier journal as an Associate Editor from 2007 to 2018. He also was on the Advisory Board Panel of Macromolecules and ACS Macro Letters. Professor Chen’s research interests are in the areas of synthesis methodology of polymers and polymer application in nanomedicine on biologics delivery, immune activation and inhibition. He has published over 300 research articles and around 30 patents approved.
Dr. SeyedReza Banihashemi is the Head of Immunology Department and an Assistant Professor at Razi Vaccine and Serum Research Institute in Karaj, Iran. He holds a Ph.D. in Clinical Immunology from Tarbiat Modares University, Tehran. With over 20 years of experience in vaccine research and development, Dr. Banihashemi designed and developed Razi Cov-Pars, Iran's domestically produced COVID-19 vaccine. Under his leadership, Razi Institute successfully conducted Phase 1, 2 and 3 clinical trials of Razi Cov-Pars.this vaccine is first intranasal covid 19 vaccine in the world.
His research focuses on mucosal Immunity , intranasal vaccine , adjuvants, drug delivery systems, immune regulation and the development of bacterial and viral vaccines. He has published over 50 papers and authored book chapters in his field. His work on nanobody technology and immunoliposomes has applications for targeted drug delivery.
In addition to conducting research, Dr. Banihashemi teaches courses in infection and immunity. He has received several awards for his scientific contributions, including for exemplary research from Razi Institute.
When not engaged in his own work, Dr. Banihashemi reviews papers for international journals.
Prof Keith Chappell
Australian Institute for Bioengineering and Nanotechnology, and School of Chemistry and Molecular Biosciences, The University of Queensland, Australia
Prof Keith Chappell is a Molecular Virologist whose research is focused on structure-based design of vaccines for medically important viruses. Keith is one of the inventors of the broadly applicable vaccine platform, molecular clamp. Molecular clamp locks viral glycoproteins into the native prefusion conformation to elicit highly protective immunity and enables consistent manufacture of highly stable, ready-to-use, fully liquid vaccines. Keith leads a team of 20 staff and students split across two major research programs: The CEPI funded Rapid Response Vaccine Pipeline which seeks to safeguard against future pandemics and contract research conducted for the UQ biotech spinout company Vicebio Ltd. In 2020, Keith co-led the University of Queensland’s effort to produce a covid vaccine, which progressed from sequence information to clinical trial dosing within 6 months, however did not progress due to interference with some existing HIV diagnostic tests. Since that time this team as produced a new covid vaccine incorporating a second-generation molecular clamp that has completed clinical testing showing favourable safety and immunogenicity profile in comparison to approved covid vaccine, Nuvaxovid (Novavax). Vicebio is also actively advancing this technology for the development of multivalent vaccine formulations to target life-threatening respiratory viruses, with a bivalent vaccine for Respiratory Syncytial virus and human metapneumovirus is currently undergoing phase I clinical trial testing.
刘存宝博士是中国医学科学院医学生物学研究所研究员,国家重点研发计划青年科学家项目负责人。近年来,以第一/通讯作者发表研究论文数十篇,授权国内发明专利5项。刘博士的实验室主要关注新佐剂亚单位疫苗和 mRNA 疫苗研究,尤其是此类疫苗诱导的细胞免疫 (CMI)。CMI 对潜伏感染病原体的疫苗至关重要,且可能对粘膜感染病原体的疫苗有贡献。他今天的主题是“一种产能不受限的经济型佐剂可在亚单位疫苗中诱导高效细胞免疫”。
George Simeon is the CEO of Curevo Vaccine. He joined Curevo at the beginning of 2019 and has over 30 years of experience in the healthcare sector working with multinational firms, start-ups, and not-for-profits. He has worked in biotech, pharmaceuticals, medical devices, IVD, and healthcare convergence technologies. He has worked extensively in Europe, Asia, and North America.
Before moving to the USA, he was based in South Korea from 2014-2018, where he worked for SK Telecom’s Healthcare Division in M&A and global strategic alliances. In 2016, he joined Sollers Partners, a cross-border investment advisory firm, while maintaining an advisory role with SK Telecom.
He has worked across Europe and the USA as an executive with Johnson & Johnson, as the founding Vice-President of Cordis Neurovascular Europe, and with GHX Europe as a Commercial Vice-President. He also spent 3 years with Novartis Global Headquarters in Switzerland working on projects in their CNS portfolio in Health Economics and Pricing.
George has also founded two start-ups and advised GS1 on their global entry and expansion into the Healthcare, High-Tech, and Customs sectors as well as on ESG practices in FMCG logistics.
George is a graduate of INSEAD (MBA) and Yale University (MPH).
Suthira Taychakhoonavudh (BSc, MSc, PhD) is a CEO and Co-founder of Baiya Phytopharm, a biotech spin-off company from faculty of pharmaceutical sciences, Chulalongkorn university, Thailand. Suthira is also an associate professor at the social and administrative pharmacy department at Faculty of Pharmaceutical Science, Chulalongkorn University with her research focus on health economics, health policy, access to medicine and health technology assessment. Her almost decade-long experience on pharmaceutical pricing and patient access has motivated her to co-founded Baiya Phytopharm with an aim to increase access to affordable medicines for patients in Thailand as well as the SEA region.
Yasuo Yoshioka, PhD
Group Leader,The Research Foundation for Microbial Diseases of Osaka University
Education;
1995-1999; Faculty of Pharmaceutical Sciences, Osaka University (Awarded the degree of B.S.).
1999-2001; Graduate School of Pharmaceutical Sciences, Osaka University (Awarded the degree of M.S.).
2001-2004; Graduate School of Pharmaceutical Sciences, Osaka University (2004; Awarded the degree of Ph.D. from Osaka University)
Brief chronology of employment;
2004-2006; Research Scientist, National Institute of Health Sciences (Tokyo, Japan)
2006-2012; Specially Appointed Associate Professor, The Center for Advanced Medical Engineering and Informatics, Osaka University (Osaka, Japan)
2012-2014; Associate Professor, Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University (Osaka, Japan)
2015-2020; Specially Appointed Associate Professor, Vaccine Creation Project, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University (Osaka, Japan)
2020-2024; Specially Appointed Professor, Vaccine Creation Project, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University (Osaka, Japan)
2015-Present: Group leader, The Research Foundation for Microbial Diseases of Osaka University (Osaka, Japan)
Arnaud Didierlaurent is an engineer in Biotechnology by training and an immunologist with a PhD in cellular immunology from the University of Lausanne in 2003 (Jean-Pierre Kraehenbuhl). Arnaud continued his work on innate immunity in the lab of Jürg Tschopp before joining the Imperial College, London, where he worked as postdoctoral fellow from 2004 to 2007 on the long-term impact of viral infection on the lungs. He was also a research fellow in Ralph Steinman's lab at the Rockefeller University in New York. Arnaud then joined the R&D department of GlaxoSmithKline in 2008 in Belgium, where he held several leading positions in vaccine research and development. Initially head of a lab investigating the mode of action of adjuvant, Arnaud became in charge of the GSK Adjuvant System portfolio and thus directly involved in the licensure of several adjuvanted vaccines.
Arnaud’s scientific contributions have consequently been focused on deciphering the interplay between innate immunity and pathogen/vaccine-specific adaptive response. With his experience in both academic and industrial settings, Arnaud has acquired a deep understanding of how vaccines are created, developed and deployed. He joined the University of Geneva in March 2020 to continue his work on translational vaccine research. He is acting as the chairman of the WHO Technical Advisory Group who provides recommendations for the Emergency Use listing of COVID-19 vaccine candidates. Since February 2023, he is an associate professor and the director of the Center of Vaccinology at the Faculty of medicine.
After obtaining his PhD in Biological Chemistry from the Johns Hopkins University, Dr. Wang started his industry career and worked at a number of biotech and pharmaceutical companies, including Grifols S.A., Novartis, and GSK Vaccines, during which he rose from scientist to leadership roles and accumulated rich vaccine and drug development experience, especially with self-replicating RNA. After leaving GSK, Dr. Wang co-founded Immorna Biotherapeutics. Under his leadership, Immorna has built cutting-edge and proprietary mRNA platform technologies and developed rich clinical pipeline spanning infectious diseases, immune-oncology, and rare genetic disease areas.
Professor Han Xuexiang is a researcher, project leader and doctoral supervisor of the Center of Excellence in Molecular and Cell Science, Chinese Academy of Sciences.
Selected in the national high-level talents (overseas) project and Shanghai Leading Talents (overseas) project.
Hanz Biotechnology (Suzhou) Co., LTD., Co-founder & CSO.
He received his bachelor's degree from Shanghai University in 2014, and his PhD from Tsinghua University in 2019 (jointly trained by National Center for Nanoscience and Technology). From 2020 to 2024, he worked as a postdoctoral researcher in the laboratory of Professor Michael J. Mitchell, University of Pennsylvania, USA, during which he collaborated with Professor Drew Weissman, winner of the Nobel Prize, on the research of LNP-mRNA vaccines and drugs. In February 2024, he joined the Center of Excellence in Molecular and Cell Science, Chinese Academy of Sciences. His research focuses on the construction of novel LNP and RNA drug delivery. He is the first-author (including co-first author) of Nat.Chem., Nat.Nanotech., Nat.Mater., Nat.Commun. He has published nearly 20 papers in other journals, authorized one Chinese patent, and applied for a number of PCT patents.
薛永博 博士
美国内华达大学细胞与分子生物学博士。
拥有超过10年以上的研发经验和5年以上的产业化经验,专注于生物技术领域的前沿创新与应用,致力于将科学研究转化为实际解决方案。
在mRNA/环状RNA(circRNA)构建、基因编辑(如CRISPR/Cas9技术)及干细胞治疗领域具有丰富的研究与实践经验,主导并参与了多项突破性项目。
作为核心研究人员,已成功发表超过10篇高水平学术论文,研究成果发表于国际知名期刊,展现了卓越的科研能力与学术影响力。
Dr. Jiangsheng Xu is the Founder and Chief Scientific Officer of General Therapeutics, Inc., specializing in the development of non-reactogenic lipid nanoparticle (LNP) technologies aimed at overcoming challenges in mRNA vaccine hesitancy and RNA medicine re-dosing. With over 15 years of hands-on experience in nanoparticle and RNA research across both academic and industry settings, Dr. Xu has contributed to leading journals, including Nature Nanotechnologyand Nature Communications, and holds 10 patents.
Pei-Yin is leading the Preclinical R&D at Hilleman Laboratories. She has more than 20 years of experience in virology and close to 10 years of experience in vaccine development. She obtained her PhD from University of Wisconsin-Madison, and pursued her postdoctoral training at Wadsworth Center, New York State Department of Health and the University of Wisconsin-Madison. Her industry experience started when she joined Sentinext Therapeutics in Malaysia, developing vaccines against enteroviruses. After Sentinext, she joined Singapore Immunology Network (SIgN), A*STAR, Singapore to develop therapeutic antibodies against viruses. She joined Hilleman Laboratories in 2021 as a Senior Scientist, and is currently the Senior Manager at Hilleman leading the Preclinical team.
博士毕业于美国弗吉尼亚州的欧道明大学,主攻方向为Vector-Borne disease中黄热病毒属(LGTV,ZIKV, DENV等病毒)依靠外泌体进行体内体外感染传播的机理研究并将成果发表在多个高影响因子杂志上(PNAS, EMI, PLoS Pathogen等)。
后在美国食品药品监督管理局FDA,CBER下设的疫苗评审研究办公室OVRR担任白橡树外国科学家项目博士后研究员(ORISE Fellow)从事以减毒风疹病毒为载体对新冠S蛋白,RSV或HIV相关蛋白表达的重组载体疫苗的研发工作。
目前在国药中生集团旗下的子公司中生复诺健生物科技有限公司担任资深科学家和学术秘书,负责多条传染病mRNA疫苗管线的早期研发和相关学术会议组织和讨论工作。
Dr. Hui Li is a dedicated professional who is currently serving as the Director of R&D at Innorna. Her work specializes in the research and development of vaccines for infectious diseases. With her vast experience in the life sciences industry, she has been involved in numerous vaccine development projects and has conducted extensive research in this field. As a leader of the vaccine R&D team at Innorna, Hui continuously innovates and has successfully developed several mRNA infectious disease vaccines, which are currently undergoing clinical trials. Founded in 2019, Innorna is a platform-based delivery technology company primarily focused on developing nucleic acid drug delivery technologies. It is among the few global high-tech firms that have mastered the LNP technology, with a proprietary mRNA platform technology. Leveraging the LNP and mRNA platform technologies, Innorna has developed pipelines for infectious disease vaccines, rare diseases, and tumor immunotherapies.
Dr. Alejandra Capozzo has an MD in Biology from the University of Buenos Aires (UBA), Argentina. She is a Doctor in Biotechnolgy also from the UBA. Her PhD thesis focused on alternative vaccines against foot-and-mouth disease directed by Dr José La Torre. She did postdoctoral studies in neonatal applied immunology at the Center for Vaccine Development (CVD) at University of Maryland (Baltimore, USA), where she worked on the development of new vaccines for neonates in the presence of maternal immunity. She has intensified her training in immunology at the National Academy of Medicine in Buenos Aires, focused on vaccines against Uremic hemolytic syndrome and animal models. Dr Capozzo worked as Market Development Manager for Latin America at Prionics (a Swiss company); and as leader of research and development in Biogenesis-Bagó, an international veterinary vaccine producer. She is also trained in sales management.
From 2008 to 2023 she was the head of the applied veterinary immunology laboratory at the Institute of Virology and Technological Innovations, a CONICET-INTA. She is currently Principal Researcher of the Argentinean national research council (CONICET), the CEO of the Global Foot and Mouth Disease Research Alliance (GFRA), President of the Argentine Association of Veterinary Immunology, coordinator of the Latin American Veterinary Immunology Network, and the Chair of the Veterinary Immunology Committee of the International Union of Immunological societies (VIC-IUIS). Dr Capozzo participates in several transboundary disease groups in FAO-WOAH, as the co-chair of the Global Coordination Committee on Foot and Mouth Disease (GCC-FMD) and as a member of the Partnership and Financial panel (PFP).
Dr Capozzo has been a professor of immunology at the School of Veterinary Medicine of the University of Buenos Aires for many years and directed 14 PhD theses. She is the Responsible Researcher of numerous national and international projects and has developed several products related to applied immunology that were transferred to Argentine and international companies. She is currently the Director of a Center focused on One health, located at the Interamerican University in Buenos Aires, since February 2024.
Dr. Hu Dong is an associate professor at Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS). Focus on optimizing the assembly and stability of FMD virus-like particle antigen based on the structure of FMD virus, combined with the research on the immune mechanism of FMD cells, to further improve the protective efficacy of FMD virus-like particle vaccine or nanoparticle vaccine, and develop a broad-spectrum vaccine. At present, he has obtained 3 new veterinary drug certificates, and related researches have been published in Nature Communications, Journal of Virology, Protein and Cell.
冯华朋,浙江理工大学-依思康医药创新佐剂和新型动物疫苗研发中心副教授,硕士生导师。博士师从我国著名禽流感专家陈化兰院士,日本东京大学医科学研究所博士后。主要研究方向为流感病毒与宿主相互作用及新型疫苗免疫佐剂研发。主持国家自然科学基金面上项目、浙江省自然科学基金等多项课题。发表SCI论文23篇,申报国际专利和国家发明专利9项,参与多株高致病性禽流感疫苗研制,日本病毒学会会员并担任Veterinary Vaccine 青年编委及多个SCI期刊的审稿专家,绍兴市“名士之乡”特支计划青年拔尖人才,参与编制佐剂团体标准4项。
Chris Netherton leads the African Swine Fever Vaccinology group and has been investigating different aspects of the life cycle of African swine fever virus (ASFV) for over twenty-five years. His studies on ASFV have encompassed analysis of individual viral proteins right through to herd transmission experiments. Chris’ earlier work on ASFV focussed on intracellular virus-host interactions with a strong emphasis on cell-biology.
The principal goal of the research carried out within the ASF Vaccinology group is to support the development of effective vaccines against this devastating disease of domestic pigs. We have identified a pool of eight ASFV genes that prevent severe disease in domestic pigs and aim to improve the protective efficacy of this combination, by characterising immune correlates of protection, identifying additional protective antigens and exploring different vaccine platforms. We are also sequencing Pirbright's reference collection of ASFV isolates to improve our understanding of the genetic diversity of this complex virus and help guide the development of cross-protective vaccines.
Dr. Frank Chia-Jung Chang obtains his Ph.D. from Life Science and Institute of Genome Science department of Taiwan Yang-Ming Medical University in 2012. He received his postdoctoral training at Molecular Biology Institute of Academia Sinica (Taiwan) and worked as visiting scholar in Frances H. Arnold’s laboratory (Nobel Prize in Chemistry winner in 2018), Chemical Engineering Department of Caltech (U.S.). He joined Reber Genetics as the supervisor of R&D Division in 2014. From 2017, Frank also works for business development and strategic layout of vaccine products (technology included).
Dr. Chang has considerable expertise in virology, microbiology, reverse vaccinology and protein engineering for industrial production. His group has successfully developed novel subunit vaccines of swine PRRSV, pan-PCV, Mycoplasma, CSFV and PEDV in Reber Genetics, furthermore, also support the study of safe vector vaccine against ASF with external partners.
Dr Robbert van der Most obtained his cum laude PhD in 1994 at Leiden University (Netherlands) on the topic of coronavirus molecular biology. He then conducted postdoctoral work on the immunology of chronic viral infection with Dr Rafi Ahmed(UCLA, Eiory University, USA) and flavivirus molecular biology with Dr Jim Strauss (Caltech, USA). Upon return to the Netherlands he worked on RSV vaccine immunology, focusing on the mechanisms of vaccine-enhanced disease. In 2004, he joined Dr Bruce Robinson's team at the University of Western Australia to study immune oncology and the immune-modifying effects of chemotherapy. In 2008, he joined GSK Vaccines in Belgium, in roles of increasing responsiblility, leadingTranslational Science, After a brief period at CEPl, he joined BioNTech as Vice-President Translational Science in 2022, leading a team of experts in the infectious disease portfolio, in 2024 he started his own consultancy business, aiming to provide scjentific and development advice to biotech and pharma companies, as well as not-for-profit organizations.
曹云龙,北京大学生物医学前沿创新中心(BIOPIC)研究员、助理教授,北大-清华生命科学联合中心研究员,北京昌平实验室领衔科学家,国家优秀青年科学基金获得者。2014年毕业于浙江大学竺可桢学院物理学专业,2019年获得哈佛大学化学博士学位。在新冠疫情期间,他围绕新冠病毒B细胞免疫应答、特异性抗体的结构与功能等开展了系统性研究,其中新冠中和抗体药物研制、新冠体液免疫响应特征和新冠突变免疫逃逸机制的创新性研究结果为抗击疫情做出了突出贡献。以第一作者、通讯作者在Nature、Cell、The Lancet Infectious Diseases、Cell Host & Microbe等期刊上发表多篇相关研究文章。相关研究成果获评2022年度“中国科学十大进展”、2022年度“中国生命科学十大进展”。其本人受邀作为WHO新冠疫苗成分技术咨询小组(TAG-CO-VAC)成员、国际流行病防范创新联盟(CEPI)科学顾问,获评2022年度北京市杰出青年中关村奖、《麻省理工科技评论》中国区“35岁以下科技创新35人”、2022年度Nature十大人物,获得国家优秀青年科学基金资助。
Nigel obtained his BSc in Microbiology and Genetics from University College London (UCL) in 1990 and an MSc in Applied Molecular Biology of Infectious Diseases (1992), PhD in Molecular Parasitology (1999) and DLSHTM (2000) from the London School of Hygiene & Tropical Medicine (LSHTM). After his PhD, he returned to UCL as a post-doctoral scientist in the Division of Infection and Immunity. In 2009 Nigel was elected as a member of the highly prestigious Medical Research Club and set up his own research group at the University of Kent. He is currently Chair and Professor in Molecular Virology, Director of the Viral Pseudotype Unit (VPU) and Director of Research and Innovation. Nigel is a Fellow of the Royal Society of Biology (FRSB), Senior Associate Member of the Royal Society of Medicine (RSM), Member of the International Society for Influenza and other Respiratory Virus Diseases (ISIRV), the Microbiology Society and the European Society for Virology (ESV). Nigel acts as external consultant for VisMederi (Italy) and RQbio (UK). He has published over 200 articles with an h-index of 53, >14k citations.
Dr. Emanuele Andreano is an immunologist with almost 10 years of experience studying B cell and antibody responses to human pathogens, and he is currently project leader at the Monoclonal Antibody Discovery Laboratory (MAD Lab), Fondazione Toscana Life Sciences, directed by his mentor Prof. Rino Rappuoli. During his training, Dr. Andreano gained extensive experience on single cell sorting of memory B cells and isolation, cloning, expression and functional/structural characterization of human monoclonal antibodies. This experience has been used to tackle different pathogens which pose serious threats for global health such as the respiratory syncytial virus (RSV), antimicrobial resistant Neisseria gonorrhoeae, SARS-CoV-2 and more recently the Monkeypox virus. The work that Dr. Andreano performed on SARS-CoV-2 led to the isolation of more than 14,000 thousand human monoclonal antibodies and to the identification of MAD0004J08, one of the most potent monoclonal ever described and evaluated in a phase II/III clinical trial for the treatment of COVID-19. Dr. Andreano first authored publications on top tier journals such as PNAS, Cell, Nature Medicine and Nature. For his scientific work, Dr. Andreano has been awarded the “COVID-19 heroes award” and has been nominated as “Rising Star” in the field of immunology by the International Union of Immunological Societies (IUIS) 2023.
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